Molecular analysis of SH3P2 function during cell migration
| Project/Area Number |
23790090
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagasaki University |
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Principal Investigator |
TANIMURA Susumu 長崎大学, 大学院・医歯薬学総合研究科, 助教 (90343342)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 癌 / シグナル伝達 / 細胞運動 / リン酸化 / MAPキナーゼ / スプライシング |
|---|
| Research Abstract |
SH3P2, a novel regulator of cell migration, binds to hnRNP-K and Myosin1E. Overexpression of SH3P2 inhibited the splicing of MMP-3/-9 mRNA. GST pull down/LC-MS/MS assay revealed that SH3 domain of Myosin1E interacts with Caveolin1-Cavin complex, which plays important roles in caveolae formation. These results indicate that SH3P2 regulates cell migration via hnRNP-K-mediated mRNA splicing of MMPs and Myosin1E-mediated caveolae formation
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Report
(3 results)
Research Products
(20 results)
