| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
GPR55 is a putative novel cannabinoid receptor and its endogenous ligand is lysophosphatidylinositol (LPI). This study demonstrated that the level of 2-arachidonlyl LPI was predominantly eleveted in mouse splenocytes stimulated with mitogen, mouse plasma, and the site of allergic inflammation using LC-MS/MS analysis. Because GPR55 is expressed mainly in the immune system and the biological activity of 2-arachidonoyl LPI is higher than those of other molecular species, 2-arachidonoyl LPI may play important roles in inflammation and immunity.
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