Development of coenzyme with enzyme selectivity and substrate-coenzyme complex inhibitor
| Project/Area Number |
23790103
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Toho University |
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Principal Investigator |
FUJII Mikio 東邦大学, 薬学部, 講師 (20311996)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | ＮＡＤ / 酵素 / 補酵素 / 立体配座 / 阻害剤 / 酵素分類 / 酵素選択性 / グルタチオンリダクターゼ / 二リン酸 |
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| Research Abstract |
Coenzyme NADs can bind to many enzymes such as alcohol dehydrogenase and hydrolases. NAD modified compound can affect to both targeted enzyme and untargeted enzymes and it may cause side-effect of drug. In this study, I study the relationship with conformation of NAD in an enzyme and family of enzymes to find the rule of the conformation of NAD in an enzyme. I succeeded in the construction of map of the conformation of NAD. Next the conformation-fixed compounds were made to test the conpounds with conformational differences select a targeted enzyme. The conformational modification of NAD could bind the targeted enzyme stronger than the other enzymes. This concept is useful for drug design.
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Report
(4 results)
Research Products
(17 results)
