Activation mechanism of nuclear receptor CAR by xenobiotics and CAR-mediated disruption of energy metabolism
| Project/Area Number |
23790104
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 転写因子 / 分子生物学 / 代謝調節 / 核内受容体 / 環境衛生系薬学 / 環境毒性学 / 環境・衛生系薬学 / 薬学 |
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| Research Abstract |
The constitutive androstane receptor (CAR) plays an important role of a defence mechanism against the toxicity of xenobiotics. In this study, we identified novel CAR binding proteins, which were AMPKβ, DP97, PRMT5 and Hsp60. We showed DP97 and PRMT5 act as a gene (or promoter)-selective co-activators for CAR. Furthermore, we showed the basal transcriptional activity of unliganded CAR was shown to be repressed by the potent liver X receptor (LXR) agonist, T0901317
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Report
(3 results)
Research Products
(30 results)
