| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
The constitutive androstane receptor (CAR) plays an important role of a defence mechanism against the toxicity of xenobiotics. In this study, we identified novel CAR binding proteins, which were AMPKβ, DP97, PRMT5 and Hsp60. We showed DP97 and PRMT5 act as a gene (or promoter)-selective co-activators for CAR. Furthermore, we showed the basal transcriptional activity of unliganded CAR was shown to be repressed by the potent liver X receptor (LXR) agonist, T0901317
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