| Project/Area Number |
23790107
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
KANNO Yosuke 同志社女子大学, 薬学部, 助教 (40416178)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | LPS / uPAR / 炎症性骨破壊 / osteoblasts / osteoclasts / 骨芽細胞 / 破骨細胞 |
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| Research Abstract |
The aim of this study was to clarify the role of uPAR on the LPS-indeuced bone resorption. We found that LPS induced the expression of uPAR in osteoclasts, but LPS did not inducethe expression of uPAR in osteoblasts. We also found that the reduction of uPAR attenuated the LPS-induced NF-kB activation, and uPAR overexpression promoted the LPS- induced NF-kB activity. In addition, we demonstrated that the binding of uPA/uPAR regulates the LPS-induced NF-kB activation and osteoclast differentiation. Moreover, we found that uPAR is associated with LPS-induced RANKL expression in osteoblasts.
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