| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
ZF21 protein promotes the cellular migration and tumor invasion via promoting the turnover of the adhesion structures at the contact sites between cell and extracellular matrix through interacting with focal adhesion kinase(EAK). In this study, I elucidated that the overexpression of the N-terminal fragment of ZF21 protein, which includes the EAK・interacting region, suppresses the tumor cell migration via inhibition ofthe interaction between ZF21 and FAK.
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