Development of the experimentalmethod to inhibitthe tumor invasion by targeting a cellmigration factor, ZF21 protein
Project/Area Number |
23790109
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Biological pharmacy
|
Research Institution | Setsunan University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 細胞生物学 / 癌細胞の浸潤抑制 |
Research Abstract |
ZF21 protein promotes the cellular migration and tumor invasion via promoting the turnover of the adhesion structures at the contact sites between cell and extracellular matrix through interacting with focal adhesion kinase(EAK). In this study, I elucidated that the overexpression of the N-terminal fragment of ZF21 protein, which includes the EAK・interacting region, suppresses the tumor cell migration via inhibition ofthe interaction between ZF21 and FAK.
|
Report
(3 results)
Research Products
(13 results)
-
-
-
-
[Journal Article] ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain2011
Author(s)
Nagano M, Hoshino D, Koshiba S, Shuo T Koshikawa N, Tomizawa T, Hayashi F, Tochio N, Harada T, Akizawa T Watanabe S, Handa N, Shirouzu M, Kigawa T, Yokoyama S, Seiki M
-
Journal Title
J Biol Chem.
Volume: 286(36)
Issue: 36
Pages: 31598-609
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-