The vitamin K biosynthetic mechanism in brain and its relevance to neurodegenerative disease
| Project/Area Number |
23790110
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 分子栄養学 / ビタミンK / メナキノン-4 / メナキノン-4生合成酵素 / アルツハイマー / 脳神経 |
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| Research Abstract |
Vitamin K is a cofactor for γ-glutamyl carboxylase (GGCX), which catalyses the post-translational modifications of several vitamin K-dependent proteins, such as coagulation factors, osteocalcin and matrix Gla protein. We recently confirmed that the PK to MK-4 conversion took place in slice culture of mouse cerebra and primary culture of mouse cerebral hemispheres. Moreover, we identified MK-4 biosynthetic enzyme [UbiA prenyltransferase domain containing 1 (UBIAD1)]. In this study, we analyzed the function of MK-4 biosynthetic enzyme in brain and the relationship of vitamin K and neurodegenerative disease. As a result, we indicated that MK-4 and MK-4 biosynthetic enzyme may have a important rule in brain.
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Report
(3 results)
Research Products
(30 results)
