| Project/Area Number |
23790113
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Research Collaborator |
KATAOKA Yasufumi 福岡大学, 薬学部, 教授 (70136513)
DOHGU Shinya 福岡大学, 薬学部, 准教授 (60399186)
MATSUMOTO Junichi 福岡大学, 薬学部, 助教 (10550064)
MACHIDA Takashi 福岡大学, 薬学部, 助教 (30586144)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脳ペリサイト / cyclophilin A / 脳インスリン抵抗性 / ペリサイト / GT1-7 / インスリン抵抗性 / シクロフィリンA / 糖尿病 / メチルグリオキサール / 脂質ラフト / 視床下部神経 / シクロフィリンＡ |
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| Research Abstract |
Brain pericytes in the microvasculature are periendothelial accessory structures of the blood-brain barrier (BBB). We previously demonstrated that pericytes increase insulin sensitivity in the hypothalamic neurons through soluble factors under the physiological conditions. However, under the pathological conditions such as diabetes mellitus (DM), a role of pericytes in hypothalamic insulin sensitivity remained obscure. The expression of cyclophilin A (CypA) and its receptor, CD147 in the brain and brain microvessels were increased in the obese mice with impaired glucose tolerance induced by high fat diet. CypA release from pericytes was much higher than that from other BBB-constituting cells under the physiological conditions. TNF-a increased CypA release from pericytes. The treatment of TNF-a combined with CypA decreased insulin sensitivity in the hypothalamic neurons. Therefore, pericytes and pericytal CypA could be involved in insulin resistance in the central nervous system.
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