| Project/Area Number |
23790114
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyushu University of Health and Welfare |
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Principal Investigator |
TOTORIBE Naoko 九州保健福祉大学, 薬学部, 准教授 (70322576)
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| Project Period (FY) |
2011-04-28 – 2013-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 糖尿病 / バイパス血管 / 薬理学 |
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| Research Abstract |
Rho/Rho kinase inhibitor significantly inhibited 5-HT-, NA-, AngII-, thorombin- and ADP-induced vasoconstrictions in the isolated human saphenous vein (SV). Furthermore, Rho/Rho kinase inhibitor significantly inhibited the enhanced vasocontractions to 5-HT, NA and AngII in diabetes mellitus (DM). These results indicate that the Rho-kinase inhibitor is a useful pharmacological tool to prevent vasospasm when the human SV from patients with DM were used as an arterial graft.
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