Analysis of the molecular mechanism of ER stress regulation by a giant ubiquitin ligase, Apollon
| Project/Area Number |
23790117
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
OHOKA Nobumichi 国立医薬品食品衛生研究所, 機能生化学部, 主任研究官 (80568519)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Apollon / 小胞体ストレス / ユビキチン / アポトーシス / IAP / UBCドメイン |
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| Research Abstract |
There are accumulating important evidences implicating ER stress-inducible apoptosis in the development and progression of neurodegenerative diseases and diabetes. In this study, we have showed that Apollon, which is an inhibitor of apoptosis protein, represses expression of an apoptosis-facilitating protein, Bim, and inhibits ER stress-dependent apoptosis, whereas during ER stress-inducible apoptosis, expression of Apollon protein is decreased. Moreover, we have demonstrated that Apollon plays a critical role in cell-cycle regulation by promoting mitotic cyclin A degradation.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.2013
Author(s)
Okuhira, K., Demizu, Y., Hattori, T., Ohoka, N., Shibata, N., Nishimaki-Mogami, T., Okuda, H., Kurihara, M., Natiro, M.
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Journal Title
Cancer Science
Volume: 104
Issue: 11
Pages: 1492-1498
DOI
Related Report
Peer Reviewed
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