| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
There are accumulating important evidences implicating ER stress-inducible apoptosis in the development and progression of neurodegenerative diseases and diabetes. In this study, we have showed that Apollon, which is an inhibitor of apoptosis protein, represses expression of an apoptosis-facilitating protein, Bim, and inhibits ER stress-dependent apoptosis, whereas during ER stress-inducible apoptosis, expression of Apollon protein is decreased. Moreover, we have demonstrated that Apollon plays a critical role in cell-cycle regulation by promoting mitotic cyclin A degradation.
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