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sPLA2-III, a mast cell-derived anaphylactic sPLA2, regulates mast cell-dependent anaphylactic responses

Research Project

Project/Area Number 23790119
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biological pharmacy
Research Institution公益財団法人東京都医学総合研究所 (2012)
Tokyo Metropolitan Organization for Medical Research (2011)

Principal Investigator

TAKETOMI Yoshitaka  公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主任研究員 (40365804)

Co-Investigator(Renkei-kenkyūsha) MURAKAMI Makoto  公益財団法人東京都医学総合研究所, 生体分子研究分野, 副参事研究員(プロジェクトリーダー) (70033496)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsマスト細胞 / アナフィラキシー / ホスホリパーゼA2 / 脂質メディエーター / アレルギー / 遺伝子改変マウス / 分化成熟
Research Abstract

Microenvironment-based alterations in phenotypes of mast cells influence the susceptibility to anaphylaxis, yet the mechanisms underlying proper maturation of mast cells toward an anaphylaxis-sensitive phenotype are incompletely understood. Here we report that group III secreted phospholipase A_2 (sPLA_2-III), a mammalian homolog of anaphylactic bee venom PLA_2, regulates this process. sPLA_2-III secreted from mast cells is coupled with fibroblastic lipocalin-type prostaglandin (PG) D synthase (L-PGDS) to provide PGD_2, which facilitates mast-cell maturation via PGD_2 receptor DP1. Mice lacking sPLA_2-III, L-PGDS or DP1, mast cell.deficient mice reconstituted with sPLA_2-III -null or DP1-null mast cells, or mast cells cultured with L-PGDS.ablated fibroblasts exhibited impaired maturation and anaphylaxis of mast cells. Thus, we describe a lipid-driven sPLA_2-III.L-PGDS.DP1 loop that drives mast cell maturation.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (94 results)

All 2013 2012 2011 Other

All Journal Article (34 results) (of which Peer Reviewed: 31 results) Presentation (42 results) (of which Invited: 2 results) Book (6 results) Remarks (11 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] 脂質ネットワークとアナフィラキシー,アレルギー・免疫2013

    • Author(s)
      武富芳隆, 村上誠
    • Journal Title

      医薬ジャーナル

      Volume: (印刷中)

    • Related Report
      2012 Final Research Report
  • [Journal Article] Lymphoid tissue phospholipase A_2 group IID resolves contact hypersensitivity by driving anti-inflammatory lipid mediators2013

    • Author(s)
      Miki, Y., Yamamoto, K., Taketomi, Y., Sato, H., Shimo, K., Kobayashi, T., Ishikawa, Y., Ishii, T., Nakanishi, H., Ikeda, K., Taguchi, R., Kabashima, K., Arita, M., Arai, H., Lambeau, G., Bollinger, J.M., Hara, S., Gelb, M.K., Murakami, M
    • Journal Title

      J. Exp. Med

      Volume: 210

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mast cell maturation is driven via a novel group III phospholipase A_2.prostaglandin D_2.DP1 receptor paracrine axis2013

    • Author(s)
      Taketomi, Y., Ueno, N., Kojima, T., Sato, H., Murase, R., Yamamoto, K., Tanaka, S., Sakanaka, M., Nakamura, M., Nishito, Y., Kawana, M., Kambe, N., Ikeda, K., Taguchi, R., Nakamizo, S., Kabashima, K., Gelb, M.H., Arita, M., Yokomizo, T., Nakamura, M., Watanabe, K., Hirai, H., Nakamura, M., Okayama, Y., Ra, C., Aritake, K., Urade, Y., Morimoto, K., Sugimoto, Y., Shimizu, T., Narumiya, S., Hara, S., Murakami, M
    • Journal Title

      Nat. Immunol

      Volume: 14

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] AMP-activated protein kinase negatively regulates Fc.RI-mediated mast cell signaling and anaphylaxis in mice2013

    • Author(s)
      Hwang, S.L., Li, X., Lu, Y., Jin, Y., Jeong, Y.T. Kim, Y.D., Lee, I.K., Taketomi, Y., Sato, H., Cho, Y.S., Murakami, M., Chang. H.W
    • Journal Title

      J. Allergy Clin. Immunol

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The expression of phospholipase A_2 group X is inversely associated with metastasis in colorectal cancer2013

    • Author(s)
      Hiyoshi, M., Kitayama, J., Kazama, S., Taketomi, Y., Murakami, M., Tsuno, N.H., Hongo, K., Kaneko, M., Sunami, E., Watanabe, T
    • Journal Title

      Oncol. Lett

      Volume: 5 Pages: 533-538

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Small RNA transcriptomes of two types of exosomes in human whole saliva determined by next generation sequencing2013

    • Author(s)
      Ogawa, Y., Taketomi, Y., Murakami, M., Tsujimoto, M., Yanoshita, R
    • Journal Title

      Biol. Pharm. Bull

      Volume: 36 Pages: 66-75

    • NAID

      130003361349

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators2013

    • Author(s)
      Miki Y, Yamamoto K, Taketomi Y, Sato H, Shimo K, Kobayashi T, Ishikawa Y, Ishii T, Nakanishi H, Ikeda K, Taguchi R, Kabashima K, Arita M, Arai H, Lambeau G, Bollinger JM, Hara S, Gelb MH, Murakami M.
    • Journal Title

      J Exp Med.

      Volume: 210 Issue: 6 Pages: 1217

    • DOI

      10.1084/jem.20121887

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mast cell maturation is driven via a novel group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.2013

    • Author(s)
      Taketomi, Y., Morimoto, K., Murakami, M., et al., 他30名
    • Journal Title

      Nature Immunol.

      Volume: (印刷中) Issue: 6 Pages: 554-63

    • DOI

      10.1038/ni.2586

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AMP-activated protein kinase negatively regulates FcεRI-mediated mast cell signaling and anaphylaxis in mice.2013

    • Author(s)
      Hwang SL, Li X, Lu Y, Jin Y, Jeong YT, Kim YD, Lee IK, Taketomi Y, Sato H, Cho YS, Murakami M, Chang HW.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 132 Issue: 3 Pages: 729-736

    • DOI

      10.1016/j.jaci.2013.02.018

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The expression of phospholipase A2 group X is inversely associated with metastasis in colorectal cancer2013

    • Author(s)
      Hiyoshi, M.
    • Journal Title

      Oncol. Lett.

      Volume: 5 Issue: 2 Pages: 533-538

    • DOI

      10.3892/ol.2012.1067

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Small RNA Transcriptomes of Two Types of Exosomes in Human Whole Saliva Determined by Next Generation Sequencing2013

    • Author(s)
      Ogawa, Y.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 36 Issue: 1 Pages: 66-75

    • DOI

      10.1248/bpb.b12-00607

    • NAID

      130003361349

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unraveling the secrets of secreted phospholipase A_22012

    • Author(s)
      Murakami, M., Taketomi, Y
    • Journal Title

      Trends Cell Mol. Biol

      Volume: 7 Pages: 57-71

    • Related Report
      2012 Final Research Report
  • [Journal Article] アナフィラキシーを制御する脂質ネットワーク2012

    • Author(s)
      武富芳隆, 村上誠
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 58 Pages: 550-559

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] Unraveling the secrets of secreted phospholipase A22012

    • Author(s)
      Murakami, M.
    • Journal Title

      Trends Cell. Mol. Biol.

      Volume: 7 Pages: 57-71

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its roles in VE-cadherin disorganization and atherosclerosis2011

    • Author(s)
      Miyazaki, T., Taketomi, Y., Takimoto, M., Lei, X., Akita, S., Kim-Kaneyama, J., Arata, S., Ohata, H., Ota, H., Murakami, M., Miyazaki, A
    • Journal Title

      Circulation

      Volume: 124 Pages: 2522-2532

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation2011

    • Author(s)
      Lu, Y., Yang, J. H., li, X., Hwangbo, K., Hwang, S. L., Taketomi, Y., Murakami, M., Chang, Y. C., Kim, C. H., Son, J. K., Chang, H. W. Emodin
    • Journal Title

      Biochem. Pharmacol

      Volume: 82 Pages: 1700-1708

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of two major intracellular phospholipase A_2 (PLA_2) in mast cells reveals crutial contribution of cytosolic PLA_2., not but Ca^<2+>-independent PLA_2., to lipid mobilization in proximal mast cells and distal fibroblasts2011

    • Author(s)
      Ueno, N., Taketomi, Y., Yamamoto, K., Hirabayashi, T., Kamei, D., Kita, Y., Shimizu, T., Shinzawa, K., Tsujimoto, Y., Ikeda, K., Taguchi, R., Murakami, M
    • Journal Title

      J. Biol. Chem

      Volume: 286 Pages: 37249-37263

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hair follicular expression and function of group X secreted phospholipase A_2 in mouse skin2011

    • Author(s)
      Yamamoto, K., Taketomi, Y., Isogai, Y., Miki, Y., Sato, H., Masuda, S., Nishito, Y., Morioka, K., Ishimoto, Y., Suzuki, N., Yokota, Y., Hanasaki, K., Ishikawa, Y., Ishii, T., Kobayashi, T., Fukami, K., Ikeda, K., Nakanishi, H., Taguchi, R., Murakami, M
    • Journal Title

      J. Biol. Chem

      Volume: 286 Pages: 37249-37263

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Physiological roles of group X-secreted phospholipase A_2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function2011

    • Author(s)
      Sato, H., Isogai, Y., Masuda, S., Taketomi, Y., Miki, Y., Kamei, D., Hara, S., Kobayashi, T., Ishikawa, Y., Ishii, T., Ikeda, K., Taguchi, R., Ishimoto, Y., Suzuki, N., Yokota, Y., Hanasaki, K., Suzuki-Yamamoto, T., Yamamoto, K., Murakami, M
    • Journal Title

      J. Biol. Chem

      Volume: 286 Pages: 11632-11648

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Secreted phospholipase A_2 revisited2011

    • Author(s)
      Murakami, M., Taketomi, Y., Sato, H., Yamamoto, K
    • Journal Title

      J. Biochem. (Tokyo)

      Volume: 150 Pages: 233-255

    • NAID

      10030587186

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Integrated lipidomics in the secreted phospholipase A_2 biology2011

    • Author(s)
      Murakami, M., Sato, H., Taketomi, Y., Yamamoto, K
    • Journal Title

      Int. J. Mol. Sci

      Volume: 12 Pages: 1474-1495

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Secreted phospholipase A_2, lipoprotein hydrolysis, and atherosclerosis: Integration with lipidmics2011

    • Author(s)
      Yamamoto, K., Isogai, Y., Sato, H., Taketomi, Y., Murakami, M
    • Journal Title

      Anal. Bioanal. Chem

      Volume: 400 Pages: 1829-1842

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recent progress in phospholipase A_2 research: From cells to animals to humans2011

    • Author(s)
      Murakami, M., Taketomi, Y., Miki, Y., Sato, H., Hirabayashi, T., Yamamoto, K
    • Journal Title

      Prog. Lipid Res

      Volume: 50 Pages: 152-192

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lipid networks in mast cell biology2011

    • Author(s)
      Taketomi, Y., Murakami, M
    • Journal Title

      Yakugaku Zasshi

      Volume: 131 Pages: 73-84

    • NAID

      130000451529

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] m-Calpain is induced in vascular endothelial cells on human atheroma and accelerates atherosclerotic lesion development through proteolytic disorganization of VE-cadherin in hypercholesterolemic mice2011

    • Author(s)
      Miyazaki, T., Taketomi, Y., Takimoto, M., Lei, X., Akita, S., Kim-Kaneyama, J., Arata, S., Ohata, H., Ota, H., Murakami, M., and Miyazaki, A.
    • Journal Title

      Circulation

      Volume: 124 Issue: 23 Pages: 2522-2532

    • DOI

      10.1161/circulationaha.111.021675

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation.2011

    • Author(s)
      Lu Y., Yang JH, li X, Hwangbo K, Hwang SL, Taketomi Y, Murakami M, Chang YC, Kim CH, Son JK, Chang HW.
    • Journal Title

      Biochem Pharmacol

      Volume: 82 Issue: 11 Pages: 1700-1708

    • DOI

      10.1016/j.bcp.2011.08.022

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of two major intracellular phospholipase A2s in mast cells reveals crucial contribution of cPLA2alpha, not iPLA2beta, to lipid mobilization in proximal mast cells and distal fibroblasts.2011

    • Author(s)
      Ueno, N., Taketomi, Y., Yamamoto, K., Hirabayashi, T., Kamei, D., Kita, Y., Shimizu, T., Shinzawa, K., Tsujimoto, Y., Ikeda, K., Taguchi, R., Murakami, M.
    • Journal Title

      J. Biol. Chem.

      Volume: 186 Issue: 43 Pages: 37249-37263

    • DOI

      10.1074/jbc.m111.290312

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Secreted phospholipase A_2 revisited2011

    • Author(s)
      Murakami, M., Taketomi, Y., Sato, H., and Yamamoto, K.
    • Journal Title

      J. Biochem.

      Volume: 150 Issue: 3 Pages: 233-255

    • DOI

      10.1093/jb/mvr088

    • NAID

      10030587186

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Integrated lipidomics in the secreted phospholipase A_2 biology2011

    • Author(s)
      Murakami, M., et al
    • Journal Title

      Int.J.Mol.Sci.

      Volume: 12 Issue: 3 Pages: 1474-1495

    • DOI

      10.3390/ijms12031474

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Secreted phospholipase A_2, lipoprotein hydrolysis, and atherosclerosis : integration with lipidomics2011

    • Author(s)
      Yamamoto, K., et al
    • Journal Title

      Anal.Bioanal.Chem.

      Volume: 400 Issue: 7 Pages: 1829-1842

    • DOI

      10.1007/s00216-011-4864-z

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hair follicular expression and function of group X secreted phospholipase A_2 in mouse skin2011

    • Author(s)
      Yamamoto, K., Taketomi, T., Isogai, Y., Miki, Y., Sato, H., Masuda, S., Nishito, Y., Morioka, K., Ishimoto, Y., Suzuki, N., Yokoya, Y., Hanasaki, K., Ishikawa, Y., Ishii, T., Kobayashi, T., Fukami, K., Ikeda, K., Nakanishi, H., Taguchi, R., and Murakami, M.
    • Journal Title

      J. Biol. Chem

      Volume: 286 Issue: 13 Pages: 11616-11631

    • DOI

      10.1074/jbc.m110.206714

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Physiological roles of group X secreted phospholipase A_2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function2011

    • Author(s)
      Sato, H., Isogai, Y., Masuda, S., Taketomi, Y., Miki, Y., Kamei, D., Hara, S., Kobayashi, T., Ishikawa, Y., Ishii, T., Ikeda, K., Taguchi, R., Ishimoto, Y., Suzuki, N., Yokota, Y., Hanasaki, K., Suzuki-Yamamoto, T., Yamamoto, K., and Murakami, M.
    • Journal Title

      J. Biol. Chem

      Volume: 286 Issue: 13 Pages: 11632-11648

    • DOI

      10.1074/jbc.m110.206755

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lipid networks in mast cell biology.2011

    • Author(s)
      Taketomi Y, Murakami M.
    • Journal Title

      Yakugaku Zasshi

      Volume: 131 Pages: 73-84

    • NAID

      130000451529

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recent progress in phospholipase A_2 research : from cells to animals to humans2011

    • Author(s)
      Murakami, M., Taketomi, Y., Miki, Y., Sato, H., Hirabayashi, T., and Yamamoto, K.
    • Journal Title

      Prog. Lipid Res

      Volume: 50 Issue: 2 Pages: 152-192

    • DOI

      10.1016/j.plipres.2010.12.001

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Group III phospholipase A_2 regulates mast cell maturation and anaphylaxis through a novel paracrine PGD_2 loop2013

    • Author(s)
      Taketomi, Y., Ueno, N., Sato, H., Yamamoto, K., Murakami, M
    • Organizer
      5^<th> International Conference on Phospholipase A_2 Mediated Signaling in Translational Medicine
    • Place of Presentation
      New Orleans, LA, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Deciphering the physiological functions of sPLA_2s2013

    • Author(s)
      Murakami, M., Taketomi, Y., Miki, Y., Sato, S., Yamamotio, K
    • Organizer
      5^<th> International Conference on Phospholipase A_2-Mediated Signaling in Translational Medicine 【招待講演】
    • Place of Presentation
      New Orleans, LA, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] ハチ毒ホスホリパーゼA_2の哺乳動物ホモログsPLA_2-IIIはプロスタグランジンD2パラクリンループを介してマスト細胞の成熟を制御する2012

    • Author(s)
      武富芳隆
    • Organizer
      平成24年度所内発表会1部会 【優秀賞受賞】
    • Place of Presentation
      東京都医学総合研究所
    • Year and Date
      2012-11-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Novel roles of phospholipase A_2 enzymes and lipid machineries in allergic inflammation2012

    • Author(s)
      Murakami, M., Taketomi, Y., Yamamoto, K
    • Place of Presentation
      Seoul, Korea【招待講演】
    • Year and Date
      2012-10-13
    • Related Report
      2012 Final Research Report
  • [Presentation] マスト細胞を制御するホスホリパーゼA_2分子群の網羅的解析2012

    • Author(s)
      上野紀子, 武富芳隆, 小島卓巳, 田中智之, 依田恵美子, 佐藤弘泰, 平林哲也, 山本圭, 原俊太郎, 村上誠
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] PLA2G3, a mammalian homolog of anaphylactic sectered phospholipase A2 in bee venom, facilitates proper maturation of mast cells through the paracrine PGD_2 loop2012

    • Author(s)
      Taketomi Y, Ueno, N., Kojima, T., Tanaka, S., Sato, H., Nishito, Y., Yamamoto, K., Sugimoto, Y., Hara, S., Murakami, M
    • Organizer
      The 12^<th> Annual International Endotoxin & Innate Immunity Society (IEIIS) Meeting
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] マスト細胞を制御する新しい脂質マシナリー2012

    • Author(s)
      武富芳隆, 上野紀子, 小島卓巳, 田中智之, 佐藤弘泰, 山本圭, 有竹浩介, 裏出良博, 杉本幸彦, 成宮周, 原俊太郎, 村上誠
    • Organizer
      第33回日本炎症・再生医学会 【優秀演題賞受賞】
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] マスト細胞を制御する新しい脂質マシナリー2012

    • Author(s)
      武富芳隆, 上野紀子, 小島卓巳, 田中智之, 佐藤弘泰, 西藤泰昌, 山本圭, 有竹浩介, 裏出良博, 杉本幸彦, 成宮周, 原俊太郎, 村上誠
    • Organizer
      第54回脂質生化学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] sPLA_2とアナフィラキシー2012

    • Author(s)
      武富芳隆, 小島卓巳, 上野紀子, 佐藤弘泰, 山本圭, 有竹浩介, 裏出良博, 杉本幸彦, 成宮周, 原俊太郎, 村上誠
    • Organizer
      新学術領域領域「生命応答を制御する脂質マシナリー」若手ワークショップ
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] PLA2G3, a mammalian homolog of anaphylactic sectered phospholipase A2 in bee venom, facilitates proper maturation of mast cells through the paracrine PGD2 loop2012

    • Author(s)
      Taketomi, Y.
    • Organizer
      The 12th Annual International Endotoxin & Innate Immunity Society (IEIIS) Meeting
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] マスト細胞を制御する新しい脂質マシナリー2012

    • Author(s)
      武富芳隆
    • Organizer
      第33回日本炎症・再生医学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] マスト細胞を制御するホスホリパーゼA2分子群の網羅的解析2012

    • Author(s)
      上野紀子
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] Novel roles of phospholipase A2 enzymes and lipid machineries in allergic inflammation2012

    • Author(s)
      Murakami, M.
    • Organizer
      International Symposium “Allergy and Inflammation”
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Secreted phospholipase A2s in skin biology2012

    • Author(s)
      Murakami, M.
    • Organizer
      The 1st International Symposium on Lipid Mediators
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 細胞内II型PAFアセチルハイドロラーゼのマスト細胞における機能解析2012

    • Author(s)
      嶋中雄太, 河野望, 武富芳隆, 向井康治朗, 村上誠, 新井洋由
    • Organizer
      日本薬学会第132回年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] 細胞内II型PAFアセチルハイドロラーゼのマスト細胞における機能解析2012

    • Author(s)
      嶋中雄太, 河野望, 武富芳隆, 向井康治朗, 村上誠, 新井洋由
    • Organizer
      第23回ビタミンE研究会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] Secreted phospholipase A_2s in anaphylaxis2011

    • Author(s)
      Taketomi, Y., Kojima, T., Ueno, N., Sato, H., Yamamoto, K., Aritake, K., Urade, Y., Sugimoto, Y., Narimiya, S., Murakami, M
    • Organizer
      第10回JBSバイオフロンティア国際シンポジウム New Aspects of Phospholipid Biology and Medicine
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] アレルギー応答を制御する新しい脂質ネットワーク2011

    • Author(s)
      村上誠, 武富芳隆
    • Organizer
      第61回日本アレルギー学会 シンポジウム「アナフィラキシーショック」
    • Place of Presentation
      東京【招待講演】
    • Related Report
      2012 Final Research Report
  • [Presentation] マスト細胞を制御する新しい脂質マシナリー2011

    • Author(s)
      武富芳隆, 村上誠
    • Organizer
      第84回日本生化学会大会 シンポジウム「炎症応答制御分子研究の最前線」
    • Place of Presentation
      京都【招待講演】
    • Related Report
      2012 Final Research Report
  • [Presentation] Secreted phospholipase A2s in anaphylaxis2011

    • Author(s)
      Taketomi Y, Kojima T, Ueno N, Sato H, Yamamoto K, Aritake K, Urade Y, Sugimoto Y, Narimiya S, Murakami M.
    • Organizer
      第10回JBSバイオフロンティア国際シンポジウム
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] Secreted phospholipase A2s in metabolic syndrome2011

    • Author(s)
      Sato H, Taketomi Y, Yamamoto K, Ikeda K, Arm JP, Murakami M.
    • Organizer
      第10回JBSバイオフロンティア国際シンポジウム
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] Secreted phospholipase A2s in atopic dermatitis2011

    • Author(s)
      Shimo K, Taketomi Y, Miki Y, Kojima T, Kobayashi T, Yamamoto K, Murakami M.
    • Organizer
      第10回JBSバイオフロンティア国際シンポジウム
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] Secreted phospholipase A2s in skin homeostasis2011

    • Author(s)
      Yamamoto K, Shimo K, Miki Y, Sato M, Taketomi Y, Ikeda K, Nakanishi H, Taguchi R, Gelb MH, Lambeau G, Murakami M.
    • Organizer
      第10回JBSバイオフロンティア国際シンポジウム
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] アレルギー応答を制御する新しい脂質ネットワーク2011

    • Author(s)
      村上誠, 武富芳隆
    • Organizer
      第61回日本アレルギー学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] Hair follicular expression and function of group X secreted phospholipase A2 in mouse skin2011

    • Author(s)
      Yamamoto K, Taketomi Y, Miki Y, Sato H, Ikeda K, Nakanishi H, Taguchi R, Murakami M.
    • Organizer
      The 8th GERLI Lipidomics meeting
    • Place of Presentation
      Lyon, France
    • Related Report
      2011 Research-status Report
  • [Presentation] 細胞内II型PAFアセチルハイドロラーゼのマスト細胞における機能解析2011

    • Author(s)
      嶋中雄太, 河野望, 武富芳隆, 向井康治朗, 村上誠, 新井洋由
    • Organizer
      フォーラム2011 衛生環境トキシコロジー
    • Place of Presentation
      石川
    • Related Report
      2011 Research-status Report
  • [Presentation] sPLA2-IIDは抗炎症脂質の産生を制御して炎症応答の寛解に関与する2011

    • Author(s)
      三木寿美, 山本圭, 下華奈子, 武富芳隆, 中西広樹, 田口良, 原俊太郎, 村上誠
    • Organizer
      第10回次世代を担う若手ファーマバイオフォーラムPBF2011
    • Place of Presentation
      仙台
    • Related Report
      2011 Research-status Report
  • [Presentation] 細胞内II型PAFアセチルハイドロラーゼのマスト細胞における機能解析2011

    • Author(s)
      嶋中雄太, 河野望, 武富芳隆, 向井康治朗, 村上誠, 新井洋由
    • Organizer
      第10回次世代を担う若手ファーマバイオフォーラムPBF2011
    • Place of Presentation
      仙台
    • Related Report
      2011 Research-status Report
  • [Presentation] プロスタグランジンE2-EP3受容体シグナルはマスト細胞の活性化を介して炎症を惹起する2011

    • Author(s)
      森本和志, 白田成俊, 武富芳隆, 瀬木-西田恵里, 田中智之, 村上誠, 成宮周, 杉本幸彦
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] アトピー性皮膚炎モデルにおける分泌性ホスホリパーゼA2分子群の機能解析2011

    • Author(s)
      下華奈子, 武富芳隆, 三木寿美, 小島卓巳, 小林哲幸, 山本圭, 村上誠
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] X型分泌性ホスホリパーゼA2の消化、神経機能、体毛形成における新規機能2011

    • Author(s)
      佐藤弘泰, 武富芳隆, 池田和貴, 田口良, 山本登志子, 山本圭, 村上誠
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] 細胞内II型PAFアセチルハイドロラーゼのマスト細胞における機能解析2011

    • Author(s)
      嶋中雄太, 河野望, 武富芳隆, 向井康治朗, 村上誠, 新井洋由
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] ヒト唾液に存在するエキソソーム中のsmall RNAの次世代シーケンサーによる網羅的解析2011

    • Author(s)
      小川裕子, 武富芳隆, 村上誠, 辻本雅文, 矢ノ下良平
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] マスト細胞を制御する新しい脂質マシナリー2011

    • Author(s)
      武富芳隆, 村上誠
    • Organizer
      第84回日本生化学会大会(招待講演)
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] Getting new insights into the functions of sPLA2s2011

    • Author(s)
      Murakami M, Sato H, Taketomi Y, Yamamoto K.
    • Organizer
      12th International conference "Bioactive lipids in cancer, inflammation, and related diseases"
    • Place of Presentation
      Seattle, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] An adipokine-like phospholipase A2 from hypertrophied adipocytes controls lipid metabolism and obesity2011

    • Author(s)
      Sato H, Taketomi Y, Ikeda K, Arm JP, Murakami M.
    • Organizer
      12th International conference "Bioactive lipids in cancer, inflammation, and related diseases"
    • Place of Presentation
      Seattle, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Group IIF phospholipase A2 maintains epidermal homeostasis2011

    • Author(s)
      Yamamoto K, Shimo K, Miki Y, Taketomi Y, Ikeda K, Nakanishi H, Taguchi R, Gelb MH, Lambeau G, Murakami M.
    • Organizer
      12th International conference "Bioactive lipids in cancer, inflammation, and related diseases"
    • Place of Presentation
      Seattle, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Biology of group X secreted phospholipase A2: from physiology to cancer and inflammatory diseases2011

    • Author(s)
      Lambeau G, Jemel I, Escoffier J, Ait-Oufella H, Li H, Guillaume C, Gora S, Surrel F, Coatrieux C, Payre C, Tanemoto A, Taketomi Y, et al.
    • Organizer
      12th International conference "Bioactive lipids in cancer, inflammation, and related diseases"
    • Place of Presentation
      Seattle, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Roles of multiple sPLA2 enzymes in obesity, hepatic steatosis, insulin tolerance, lipoprotein metabolism and adipose inflammation2011

    • Author(s)
      Sato H, Taketomi Y, Yamamoto K, Murakami M.
    • Organizer
      The 30th Naito conference on membrane dynamics and lipid biology [II]: domeins, droplets and diseases.
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] 脂肪過栄養により誘導されるsPLA2-Vは全身的な脂質代謝異常を制御する2011

    • Author(s)
      佐藤弘泰, 武富芳隆, 山本圭, 磯貝有紀, 石川由紀雄, 石井壽晴, 原俊太郎, 村上誠
    • Organizer
      第53回日本脂質生化学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 外根鞘に局在するsPLA2-Xは体毛の恒常性維持に関与する2011

    • Author(s)
      山本圭, 武富芳隆, 三木寿美, 佐藤弘泰, 池田和貴, 中西広樹, 田口良, 村上誠
    • Organizer
      第53回日本脂質生化学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 樹状細胞のsPLA2-IIDは炎症応答の緩解を制御する2011

    • Author(s)
      三木寿美, 山本圭, 下華奈子, 武富芳隆, 中西広樹, 田口良, 原俊太郎, 村上誠
    • Organizer
      第53回日本脂質生化学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Book] PLA2, 動脈硬化症の新しい診断・治療標的. 倉林正彦、山岸昌一郎編2012

    • Author(s)
      武富芳隆, 村上誠
    • Publisher
      メディカルレビュー社
    • Related Report
      2012 Final Research Report
  • [Book] 動脈硬化症の新しい診断・治療標的2012

    • Author(s)
      武富芳隆
    • Total Pages
      12
    • Publisher
      メディカルレビュー社
    • Related Report
      2012 Annual Research Report
  • [Book] Phospholipase A2 as a potential target of airway diseases. Obstructive Airway Diseases: Role of Lipid Mediators. eds by Abhjit Ray2011

    • Author(s)
      Taketomi, Y., Murakami, M
    • Publisher
      Taylor & Francis Group
    • Related Report
      2012 Final Research Report
  • [Book] 脂質異常症(高脂血症), 生命科学研究の戦略:疾患モデルマウスと表現型解析2011

    • Author(s)
      佐藤弘泰, 武富芳隆, 山本圭, 村上誠
    • Related Report
      2012 Final Research Report
  • [Book] Obstructive Airway Diseases: Role of Lipid Mediators2011

    • Author(s)
      Taketomi, Y., Murakami, M. Phospholipase A2 as a potential target of airway diseases.
    • Total Pages
      29
    • Publisher
      Taylor & Francis Group
    • Related Report
      2011 Research-status Report
  • [Book] 生命科学研究の戦略:疾患モデルマウスと表現型解析2011

    • Author(s)
      佐藤弘泰, 武富芳隆, 山本圭, 村上誠
    • Total Pages
      10
    • Publisher
      中山書店
    • Related Report
      2011 Research-status Report
  • [Remarks] プレス発表: 東京都報道発表:体に蓄えられた魚の油が病気を止める .体に優しい脂質を動かし炎症にブレーキをかける酵素の発見.. 2013年5月24日

    • URL

      http://www.metro.tokyo.jp/INET/OSHIRASE/2013/05/20n5o400.htm

    • Related Report
      2012 Final Research Report
  • [Remarks] マイナビニュース:東京都医学研など、脂質成分が炎症にブレーキをかける仕組みを解明. 2013年5月27日

    • URL

      http://news.mynavi.jp/news/2013/05/27/128/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks] ライフサイエンス 新着論文レビュー:村上誠, 武富芳隆. III型ホスホリパーゼA2.プロスタグランジンD2経路はマスト細胞の成熟を制御する. 2013年5月10日

    • URL

      http://first.lifesciencedb.jp/archives/6996#more-6996

    • Related Report
      2012 Final Research Report
  • [Remarks] マイナビニュース:花粉症などのアレルギー克服に期待 .東京都、新たな脂質代謝経路を解明. 2013年5月1日

    • URL

      http://news.mynavi.jp/news/2013/05/01/113/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks] プレス発表: 東京都報道発表:アレルギーを起こす新しい脂質代謝経路を解明 .花粉症等アレルギー克服に向けての新しい創薬に期待.. 2013年4月30日

    • URL

      http://www.metro.tokyo.jp/INET/OSHIRASE/2013/04/20n4u600.htm

    • Related Report
      2012 Final Research Report
  • [Remarks] III型ホスホリパーゼ-プロスタグランジンD2経路はマスト細胞の成熟を制御する

    • URL

      http://first.lifesciencedb.jp/archives/6996#more-6996

    • Related Report
      2012 Annual Research Report
  • [Remarks] アレルギーを起こす新しい脂質代謝経路を解明

    • URL

      http://www.metro.tokyo.jp/INET/OSHIRASE/2013/04/20n4u600.htm

    • Related Report
      2012 Annual Research Report
  • [Remarks] アレルギーを起こす新しい脂質代謝経路を解明

    • URL

      http://www.igakuken.or.jp/research/topics/2013/0430.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.igakuken.or.jp/lipid/research7.html

    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.igakuken.or.jp/lipid/project_j.html

    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.igakuken.or.jp/lipid/research6.html

    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] ホスホリパーゼA2G3を指標としたスクリーニング方法2013

    • Inventor(s)
      村上誠、武富芳隆
    • Industrial Property Rights Holder
      村上誠、武富芳隆
    • Industrial Property Number
      2013-073775
    • Filing Date
      2013-03-29
    • Related Report
      2012 Annual Research Report 2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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