sPLA2-III, a mast cell-derived anaphylactic sPLA2, regulates mast cell-dependent anaphylactic responses

• Project/Area Number: 23790119
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: 公益財団法人東京都医学総合研究所 (2012); Tokyo Metropolitan Organization for Medical Research (2011)
• Principal Investigator: TAKETOMI Yoshitaka 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主任研究員 (40365804)
• Co-Investigator(Renkei-kenkyūsha): MURAKAMI Makoto 公益財団法人東京都医学総合研究所, 生体分子研究分野, 副参事研究員(プロジェクトリーダー) (70033496)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: マスト細胞 / アナフィラキシー / ホスホリパーゼA2 / 脂質メディエーター / アレルギー / 遺伝子改変マウス / 分化成熟

Research Abstract

Microenvironment-based alterations in phenotypes of mast cells influence the susceptibility to anaphylaxis, yet the mechanisms underlying proper maturation of mast cells toward an anaphylaxis-sensitive phenotype are incompletely understood. Here we report that group III secreted phospholipase A_2 (sPLA_2-III), a mammalian homolog of anaphylactic bee venom PLA_2, regulates this process. sPLA_2-III secreted from mast cells is coupled with fibroblastic lipocalin-type prostaglandin (PG) D synthase (L-PGDS) to provide PGD_2, which facilitates mast-cell maturation via PGD_2 receptor DP1. Mice lacking sPLA_2-III, L-PGDS or DP1, mast cell.deficient mice reconstituted with sPLA_2-III -null or DP1-null mast cells, or mast cells cultured with L-PGDS.ablated fibroblasts exhibited impaired maturation and anaphylaxis of mast cells. Thus, we describe a lipid-driven sPLA_2-III.L-PGDS.DP1 loop that drives mast cell maturation.

Research Products

• [Journal Article] 脂質ネットワークとアナフィラキシー,アレルギー・免疫 (2013)
  • Author(s): 武富芳隆, 村上誠
  • Journal Title: 医薬ジャーナル Volume: (印刷中)
• [Journal Article] Lymphoid tissue phospholipase A_2 group IID resolves contact hypersensitivity by driving anti-inflammatory lipid mediators (2013)
  • Author(s): Miki, Y., Yamamoto, K., Taketomi, Y., Sato, H., Shimo, K., Kobayashi, T., Ishikawa, Y., Ishii, T., Nakanishi, H., Ikeda, K., Taguchi, R., Kabashima, K., Arita, M., Arai, H., Lambeau, G., Bollinger, J.M., Hara, S., Gelb, M.K., Murakami, M
  • Journal Title: J. Exp. Med Volume: 210
  • Peer Reviewed
• [Journal Article] Mast cell maturation is driven via a novel group III phospholipase A_2.prostaglandin D_2.DP1 receptor paracrine axis (2013)
  • Author(s): Taketomi, Y., Ueno, N., Kojima, T., Sato, H., Murase, R., Yamamoto, K., Tanaka, S., Sakanaka, M., Nakamura, M., Nishito, Y., Kawana, M., Kambe, N., Ikeda, K., Taguchi, R., Nakamizo, S., Kabashima, K., Gelb, M.H., Arita, M., Yokomizo, T., Nakamura, M., Watanabe, K., Hirai, H., Nakamura, M., Okayama, Y., Ra, C., Aritake, K., Urade, Y., Morimoto, K., Sugimoto, Y., Shimizu, T., Narumiya, S., Hara, S., Murakami, M
  • Journal Title: Nat. Immunol Volume: 14
  • Peer Reviewed
• [Journal Article] AMP-activated protein kinase negatively regulates Fc.RI-mediated mast cell signaling and anaphylaxis in mice (2013)
  • Author(s): Hwang, S.L., Li, X., Lu, Y., Jin, Y., Jeong, Y.T. Kim, Y.D., Lee, I.K., Taketomi, Y., Sato, H., Cho, Y.S., Murakami, M., Chang. H.W
  • Journal Title: J. Allergy Clin. Immunol Volume: (in press)
  • Peer Reviewed
• [Journal Article] The expression of phospholipase A_2 group X is inversely associated with metastasis in colorectal cancer (2013)
  • Author(s): Hiyoshi, M., Kitayama, J., Kazama, S., Taketomi, Y., Murakami, M., Tsuno, N.H., Hongo, K., Kaneko, M., Sunami, E., Watanabe, T
  • Journal Title: Oncol. Lett Volume: 5 Pages: 533-538
  • Peer Reviewed
• [Journal Article] Small RNA transcriptomes of two types of exosomes in human whole saliva determined by next generation sequencing (2013)
  • Author(s): Ogawa, Y., Taketomi, Y., Murakami, M., Tsujimoto, M., Yanoshita, R
  • Journal Title: Biol. Pharm. Bull Volume: 36 Pages: 66-75
  • NAID: 130003361349
  • Peer Reviewed
• [Journal Article] Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving anti-inflammatory lipid mediators. (2013)
  • Author(s): Miki Y, Yamamoto K, Taketomi Y, Sato H, Shimo K, Kobayashi T, Ishikawa Y, Ishii T, Nakanishi H, Ikeda K, Taguchi R, Kabashima K, Arita M, Arai H, Lambeau G, Bollinger JM, Hara S, Gelb MH, Murakami M.
  • Journal Title: The Journal of Experimental Medicine Volume: 210 Pages: 1217-1234
  • DOI: 10.1084/jem.20121887
  • Peer Reviewed
• [Journal Article] Mast cell maturation is driven via a novel group III phospholipase A2–prostaglandin D2–DP1 receptor paracrine axis. (2013)
  • Author(s): Taketomi, Y., Morimoto, K., Murakami, M., et al., 他30名
  • Journal Title: Nat. Immunol. Volume: (印刷中) Pages: 544-563
  • DOI: 10.1038/ni.2586
  • Peer Reviewed
• [Journal Article] AMP-activated protein kinase negatively regulates Fc.RI-mediated mast cell signaling and anaphylaxis in mice (2013)
  • Author(s): Hwang SL, Li X, Lu Y, Jin Y, Jeong YT, Kim YD, Lee IK, Taketomi Y, Sato H, Cho YS, Murakami M, Chang HW.
  • Journal Title: J. Allergy Clin. Immunol. published onlin Volume: 132 Pages: 729-736
  • DOI: 10.1016/j.jaci.2013.02.018
  • Peer Reviewed
• [Journal Article] The expression of phospholipase A2 group X is inversely associated with metastasis in colorectal cancer. (2013)
  • Author(s): Hiyoshi, M.
  • Journal Title: Oncol Lett. Volume: 5 Pages: 533-538
  • DOI: 10.3892/ol.2012.1067
  • Peer Reviewed
• [Journal Article] Small RNA Transcriptomes of Two Types of Exosomes in Human Whole Saliva Determined by Next Generation Sequencing (2013)
  • Author(s): Ogawa, Y.
  • Journal Title: Biol. Pharm. Bull. Volume: 36 Issue: 1 Pages: 66-75
  • DOI: 10.1248/bpb.b12-00607
  • NAID: 130003361349
  • Peer Reviewed
• [Journal Article] Unraveling the secrets of secreted phospholipase A_2 (2012)
  • Author(s): Murakami, M., Taketomi, Y
  • Journal Title: Trends Cell Mol. Biol Volume: 7 Pages: 57-71
• [Journal Article] アナフィラキシーを制御する脂質ネットワーク (2012)
  • Author(s): 武富芳隆, 村上誠
  • Journal Title: 臨床免疫・アレルギー科 Volume: 58 Pages: 550-559
• [Journal Article] Unraveling the secrets of secreted phospholipase A2 (2012)
  • Author(s): Murakami, M.
  • Journal Title: Trends Cell. Mol. Biol. Volume: 7 Pages: 57-71
  • Peer Reviewed
• [Journal Article] m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its roles in VE-cadherin disorganization and atherosclerosis (2011)
  • Author(s): Miyazaki, T., Taketomi, Y., Takimoto, M., Lei, X., Akita, S., Kim-Kaneyama, J., Arata, S., Ohata, H., Ota, H., Murakami, M., Miyazaki, A
  • Journal Title: Circulation Volume: 124 Pages: 2522-2532
  • Peer Reviewed
• [Journal Article] a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation (2011)
  • Author(s): Lu, Y., Yang, J. H., li, X., Hwangbo, K., Hwang, S. L., Taketomi, Y., Murakami, M., Chang, Y. C., Kim, C. H., Son, J. K., Chang, H. W. Emodin
  • Journal Title: Biochem. Pharmacol Volume: 82 Pages: 1700-1708
  • Peer Reviewed
• [Journal Article] Analysis of two major intracellular phospholipase A_2 (PLA_2) in mast cells reveals crutial contribution of cytosolic PLA_2., not but Ca^<2+>-independent PLA_2., to lipid mobilization in proximal mast cells and distal fibroblasts (2011)
  • Author(s): Ueno, N., Taketomi, Y., Yamamoto, K., Hirabayashi, T., Kamei, D., Kita, Y., Shimizu, T., Shinzawa, K., Tsujimoto, Y., Ikeda, K., Taguchi, R., Murakami, M
  • Journal Title: J. Biol. Chem Volume: 286 Pages: 37249-37263
  • Peer Reviewed
• [Journal Article] Hair follicular expression and function of group X secreted phospholipase A_2 in mouse skin (2011)
  • Author(s): Yamamoto, K., Taketomi, Y., Isogai, Y., Miki, Y., Sato, H., Masuda, S., Nishito, Y., Morioka, K., Ishimoto, Y., Suzuki, N., Yokota, Y., Hanasaki, K., Ishikawa, Y., Ishii, T., Kobayashi, T., Fukami, K., Ikeda, K., Nakanishi, H., Taguchi, R., Murakami, M
  • Journal Title: J. Biol. Chem Volume: 286 Pages: 37249-37263
  • Peer Reviewed
• [Journal Article] Physiological roles of group X-secreted phospholipase A_2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function (2011)
  • Author(s): Sato, H., Isogai, Y., Masuda, S., Taketomi, Y., Miki, Y., Kamei, D., Hara, S., Kobayashi, T., Ishikawa, Y., Ishii, T., Ikeda, K., Taguchi, R., Ishimoto, Y., Suzuki, N., Yokota, Y., Hanasaki, K., Suzuki-Yamamoto, T., Yamamoto, K., Murakami, M
  • Journal Title: J. Biol. Chem Volume: 286 Pages: 11632-11648
  • Peer Reviewed
• [Journal Article] Secreted phospholipase A_2 revisited (2011)
  • Author(s): Murakami, M., Taketomi, Y., Sato, H., Yamamoto, K
  • Journal Title: J. Biochem. (Tokyo) Volume: 150 Pages: 233-255
  • NAID: 10030587186
  • Peer Reviewed
• [Journal Article] Integrated lipidomics in the secreted phospholipase A_2 biology (2011)
  • Author(s): Murakami, M., Sato, H., Taketomi, Y., Yamamoto, K
  • Journal Title: Int. J. Mol. Sci Volume: 12 Pages: 1474-1495
  • Peer Reviewed
• [Journal Article] Secreted phospholipase A_2, lipoprotein hydrolysis, and atherosclerosis: Integration with lipidmics (2011)
  • Author(s): Yamamoto, K., Isogai, Y., Sato, H., Taketomi, Y., Murakami, M
  • Journal Title: Anal. Bioanal. Chem Volume: 400 Pages: 1829-1842
  • Peer Reviewed
• [Journal Article] Recent progress in phospholipase A_2 research: From cells to animals to humans (2011)
  • Author(s): Murakami, M., Taketomi, Y., Miki, Y., Sato, H., Hirabayashi, T., Yamamoto, K
  • Journal Title: Prog. Lipid Res Volume: 50 Pages: 152-192
  • Peer Reviewed
• [Journal Article] Lipid networks in mast cell biology (2011)
  • Author(s): Taketomi, Y., Murakami, M
  • Journal Title: Yakugaku Zasshi Volume: 131 Pages: 73-84
  • NAID: 130000451529
  • Peer Reviewed
• [Journal Article] m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its roles in VE-cadherin disorganization and atherosclerosis. (2011)
  • Author(s): Miyazaki, T., Taketomi, Y., Takimoto, M., Lei, X., Akita, S., Kim-Kaneyama, J., Arata, S., Ohata, H., Ota, H., Murakami, M., and Miyazaki, A.
  • Journal Title: Circulation Volume: 124 Pages: 2522-2532
  • DOI: 10.1161/circulationaha.111.021675
  • Peer Reviewed
• [Journal Article] Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation. (2011)
  • Author(s): Lu Y., Yang JH, li X, Hwangbo K, Hwang SL, Taketomi Y, Murakami M, Chang YC, Kim CH, Son JK, Chang HW.
  • Journal Title: Biochem Pharmacol Volume: 82 Pages: 1700-1708
  • DOI: 10.1016/j.bcp.2011.08.022
  • Peer Reviewed
• [Journal Article] Analysis of two major intracellular phospholipase A2 (PLA2) in mast cells reveals crutial contribution of cytosolic PLA2α, not but Ca2+-independent PLA2β, to lipid mobilization in proximal mast cells and distal fibroblasts. (2011)
  • Author(s): Ueno, N., Taketomi, Y., Yamamoto, K., Hirabayashi, T., Kamei, D., Kita, Y., Shimizu, T., Shinzawa, K., Tsujimoto, Y., Ikeda, K., Taguchi, R., Murakami, M.
  • Journal Title: J Biol Chem. Volume: 186 Pages: 37249-37263
  • DOI: 10.1074/jbc.m111.290312
  • Peer Reviewed
• [Journal Article] Secreted phospholipase A2 revisited. (2011)
  • Author(s): Murakami, M., Taketomi, Y., Sato, H., and Yamamoto, K.
  • Journal Title: J Biochem. Volume: 150 Pages: 233-255
  • DOI: 10.1093/jb/mvr088
  • Peer Reviewed
• [Journal Article] Integrated lipidomics in the secreted phospholipase A2 biology. (2011)
  • Author(s): Murakami, M., et al
  • Journal Title: Int J Mol Sci Volume: 12 Pages: 1474-1495
  • DOI: 10.3390/ijms12031474
  • Peer Reviewed
• [Journal Article] Secreted phospholipase A2, lipoprotein hydrolysis, and atherosclerosis: Integration with lipidmics. (2011)
  • Author(s): Yamamoto, K., et al
  • Journal Title: Anal Bioanal Chem. Volume: 400 Pages: 1829-1842
  • DOI: 10.1007/s00216-011-4864-z
  • Peer Reviewed
• [Journal Article] Hair follicular expression and function of group X secreted phospholipase A2 in mouse skin. (2011)
  • Author(s): Yamamoto, K., Taketomi, T., Isogai, Y., Miki, Y., Sato, H., Masuda, S., Nishito, Y., Morioka, K., Ishimoto, Y., Suzuki, N., Yokoya, Y., Hanasaki, K., Ishikawa, Y., Ishii, T., Kobayashi, T., Fukami, K., Ikeda, K., Nakanishi, H., Taguchi, R., and Murakami, M.
  • Journal Title: J Biol Chem. Volume: 286 Pages: 11616-11631
  • DOI: 10.1074/jbc.m110.206714
  • Peer Reviewed
• [Journal Article] Physiological roles of group X-secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function. (2011)
  • Author(s): Sato, H., Isogai, Y., Masuda, S., Taketomi, Y., Miki, Y., Kamei, D., Hara, S., Kobayashi, T., Ishikawa, Y., Ishii, T., Ikeda, K., Taguchi, R., Ishimoto, Y., Suzuki, N., Yokota, Y., Hanasaki, K., Suzuki-Yamamoto, T., Yamamoto, K., and Murakami, M.
  • Journal Title: J Biol Chem Volume: 286 Pages: 11632-11648
  • DOI: 10.1074/jbc.m110.206755
  • Peer Reviewed
• [Journal Article] Lipid networks in mast cell biology. (2011)
  • Author(s): Taketomi Y, Murakami M.
  • Journal Title: Yakugaku Zasshi Volume: 131 Pages: 73-84
  • NAID: 130000451529
  • Peer Reviewed
• [Journal Article] Recent progress in phospholipase A2 research: From cells to animals to humans. (2011)
  • Author(s): Murakami, M., Taketomi, Y., Miki, Y., Sato, H., Hirabayashi, T., and Yamamoto, K.
  • Journal Title: Prog Lipid Res. Volume: 50 Pages: 152-192
  • DOI: 10.1016/j.plipres.2010.12.001
  • Peer Reviewed
• [Presentation] Group III phospholipase A_2 regulates mast cell maturation and anaphylaxis through a novel paracrine PGD_2 loop (2013)
  • Author(s): Taketomi, Y., Ueno, N., Sato, H., Yamamoto, K., Murakami, M
  • Organizer: 5^<th> International Conference on Phospholipase A_2 Mediated Signaling in Translational Medicine
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] Deciphering the physiological functions of sPLA_2s (2013)
  • Author(s): Murakami, M., Taketomi, Y., Miki, Y., Sato, S., Yamamotio, K
  • Organizer: 5^<th> International Conference on Phospholipase A_2-Mediated Signaling in Translational Medicine 【招待講演】
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] ハチ毒ホスホリパーゼA_2の哺乳動物ホモログsPLA_2-IIIはプロスタグランジンD2パラクリンループを介してマスト細胞の成熟を制御する (2012)
  • Author(s): 武富芳隆
  • Organizer: 平成24年度所内発表会1部会 【優秀賞受賞】
  • Place of Presentation: 東京都医学総合研究所
  • Year and Date: 2012-11-21
• [Presentation] Novel roles of phospholipase A_2 enzymes and lipid machineries in allergic inflammation (2012)
  • Author(s): Murakami, M., Taketomi, Y., Yamamoto, K
  • Place of Presentation: Seoul, Korea【招待講演】
  • Year and Date: 2012-10-13
• [Presentation] マスト細胞を制御するホスホリパーゼA_2分子群の網羅的解析 (2012)
  • Author(s): 上野紀子, 武富芳隆, 小島卓巳, 田中智之, 依田恵美子, 佐藤弘泰, 平林哲也, 山本圭, 原俊太郎, 村上誠
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
• [Presentation] PLA2G3, a mammalian homolog of anaphylactic sectered phospholipase A2 in bee venom, facilitates proper maturation of mast cells through the paracrine PGD_2 loop (2012)
  • Author(s): Taketomi Y, Ueno, N., Kojima, T., Tanaka, S., Sato, H., Nishito, Y., Yamamoto, K., Sugimoto, Y., Hara, S., Murakami, M
  • Organizer: The 12^<th> Annual International Endotoxin & Innate Immunity Society (IEIIS) Meeting
  • Place of Presentation: Tokyo, Japan
• [Presentation] マスト細胞を制御する新しい脂質マシナリー (2012)
  • Author(s): 武富芳隆, 上野紀子, 小島卓巳, 田中智之, 佐藤弘泰, 山本圭, 有竹浩介, 裏出良博, 杉本幸彦, 成宮周, 原俊太郎, 村上誠
  • Organizer: 第33回日本炎症・再生医学会 【優秀演題賞受賞】
  • Place of Presentation: 福岡
• [Presentation] マスト細胞を制御する新しい脂質マシナリー (2012)
  • Author(s): 武富芳隆, 上野紀子, 小島卓巳, 田中智之, 佐藤弘泰, 西藤泰昌, 山本圭, 有竹浩介, 裏出良博, 杉本幸彦, 成宮周, 原俊太郎, 村上誠
  • Organizer: 第54回脂質生化学会
  • Place of Presentation: 福岡
• [Presentation] sPLA_2とアナフィラキシー (2012)
  • Author(s): 武富芳隆, 小島卓巳, 上野紀子, 佐藤弘泰, 山本圭, 有竹浩介, 裏出良博, 杉本幸彦, 成宮周, 原俊太郎, 村上誠
  • Organizer: 新学術領域領域「生命応答を制御する脂質マシナリー」若手ワークショップ
  • Place of Presentation: 東京
• [Presentation] PLA2G3, a mammalian homolog of anaphylactic sectered phospholipase A2 in bee venom, facilitates proper maturation of mast cells through the paracrine PGD2 loop (2012)
  • Author(s): Taketomi, Y.
  • Organizer: The 12th Annual International Endotoxin & Innate Immunity Society (IEIIS) Meeting
  • Place of Presentation: Tokyo, Japan
• [Presentation] マスト細胞を制御するホスホリパーゼA2分子群の網羅的解析 (2012)
  • Author(s): 上野紀子
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
• [Presentation] Novel roles of phospholipase A2 enzymes and lipid machineries in allergic inflammation (2012)
  • Author(s): Murakami, M.
  • Organizer: International Symposium “Allergy and Inflammation”
  • Place of Presentation: Seoul, Korea
  • Invited
• [Presentation] Secreted phospholipase A2s in skin biology (2012)
  • Author(s): Murakami, M.
  • Organizer: The 1st International Symposium on Lipid Mediators
  • Place of Presentation: Fukuoka, Japan
  • Invited
• [Presentation] 細胞内II型PAFアセチルハイドロラーゼのマスト細胞における機能解析 (2012)
  • Author(s): 嶋中雄太, 河野望, 武富芳隆, 向井康治朗, 村上誠, 新井洋由
  • Organizer: 日本薬学会第132回年会
  • Place of Presentation: 札幌
• [Presentation] 細胞内II型PAFアセチルハイドロラーゼのマスト細胞における機能解析 (2012)
  • Author(s): 嶋中雄太, 河野望, 武富芳隆, 向井康治朗, 村上誠, 新井洋由
  • Organizer: 第23回ビタミンE研究会
  • Place of Presentation: 東京
• [Presentation] Secreted phospholipase A_2s in anaphylaxis (2011)
  • Author(s): Taketomi, Y., Kojima, T., Ueno, N., Sato, H., Yamamoto, K., Aritake, K., Urade, Y., Sugimoto, Y., Narimiya, S., Murakami, M
  • Organizer: 第10回JBSバイオフロンティア国際シンポジウム New Aspects of Phospholipid Biology and Medicine
  • Place of Presentation: Fukuoka, Japan
• [Presentation] アレルギー応答を制御する新しい脂質ネットワーク (2011)
  • Author(s): 村上誠, 武富芳隆
  • Organizer: 第61回日本アレルギー学会 シンポジウム「アナフィラキシーショック」
  • Place of Presentation: 東京【招待講演】
• [Presentation] マスト細胞を制御する新しい脂質マシナリー (2011)
  • Author(s): 武富芳隆, 村上誠
  • Organizer: 第84回日本生化学会大会 シンポジウム「炎症応答制御分子研究の最前線」
  • Place of Presentation: 京都【招待講演】
• [Presentation] Secreted phospholipase A2s in anaphylaxis (2011)
  • Author(s): Taketomi Y, Kojima T, Ueno N, Sato H, Yamamoto K, Aritake K, Urade Y, Sugimoto Y, Narimiya S, Murakami M.
  • Organizer: 第10回JBSバイオフロンティア国際シンポジウム
  • Place of Presentation: 福岡
• [Presentation] Secreted phospholipase A2s in metabolic syndrome (2011)
  • Author(s): Sato H, Taketomi Y, Yamamoto K, Ikeda K, Arm JP, Murakami M.
  • Organizer: 第10回JBSバイオフロンティア国際シンポジウム
  • Place of Presentation: 福岡
• [Presentation] Secreted phospholipase A2s in atopic dermatitis (2011)
  • Author(s): Shimo K, Taketomi Y, Miki Y, Kojima T, Kobayashi T, Yamamoto K, Murakami M.
  • Organizer: 第10回JBSバイオフロンティア国際シンポジウム
  • Place of Presentation: 福岡
• [Presentation] Secreted phospholipase A2s in skin homeostasis (2011)
  • Author(s): Yamamoto K, Shimo K, Miki Y, Sato M, Taketomi Y, Ikeda K, Nakanishi H, Taguchi R, Gelb MH, Lambeau G, Murakami M.
  • Organizer: 第10回JBSバイオフロンティア国際シンポジウム
  • Place of Presentation: 福岡
• [Presentation] アレルギー応答を制御する新しい脂質ネットワーク (2011)
  • Author(s): 村上誠, 武富芳隆
  • Organizer: 第61回日本アレルギー学会
  • Place of Presentation: 東京
• [Presentation] Hair follicular expression and function of group X secreted phospholipase A2 in mouse skin (2011)
  • Author(s): Yamamoto K, Taketomi Y, Miki Y, Sato H, Ikeda K, Nakanishi H, Taguchi R, Murakami M.
  • Organizer: The 8th GERLI Lipidomics meeting
  • Place of Presentation: Lyon, France
• [Presentation] 細胞内II型PAFアセチルハイドロラーゼのマスト細胞における機能解析 (2011)
  • Author(s): 嶋中雄太, 河野望, 武富芳隆, 向井康治朗, 村上誠, 新井洋由
  • Organizer: フォーラム2011 衛生環境トキシコロジー
  • Place of Presentation: 石川
• [Presentation] sPLA2-IIDは抗炎症脂質の産生を制御して炎症応答の寛解に関与する (2011)
  • Author(s): 三木寿美, 山本圭, 下華奈子, 武富芳隆, 中西広樹, 田口良, 原俊太郎, 村上誠
  • Organizer: 第10回次世代を担う若手ファーマバイオフォーラムPBF2011
  • Place of Presentation: 仙台
• [Presentation] 細胞内II型PAFアセチルハイドロラーゼのマスト細胞における機能解析 (2011)
  • Author(s): 嶋中雄太, 河野望, 武富芳隆, 向井康治朗, 村上誠, 新井洋由
  • Organizer: 第10回次世代を担う若手ファーマバイオフォーラムPBF2011
  • Place of Presentation: 仙台
• [Presentation] プロスタグランジンE2-EP3受容体シグナルはマスト細胞の活性化を介して炎症を惹起する (2011)
  • Author(s): 森本和志, 白田成俊, 武富芳隆, 瀬木-西田恵里, 田中智之, 村上誠, 成宮周, 杉本幸彦
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
• [Presentation] アトピー性皮膚炎モデルにおける分泌性ホスホリパーゼA2分子群の機能解析 (2011)
  • Author(s): 下華奈子, 武富芳隆, 三木寿美, 小島卓巳, 小林哲幸, 山本圭, 村上誠
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
• [Presentation] X型分泌性ホスホリパーゼA2の消化、神経機能、体毛形成における新規機能 (2011)
  • Author(s): 佐藤弘泰, 武富芳隆, 池田和貴, 田口良, 山本登志子, 山本圭, 村上誠
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
• [Presentation] 細胞内II型PAFアセチルハイドロラーゼのマスト細胞における機能解析 (2011)
  • Author(s): 嶋中雄太, 河野望, 武富芳隆, 向井康治朗, 村上誠, 新井洋由
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
• [Presentation] ヒト唾液に存在するエキソソーム中のsmall RNAの次世代シーケンサーによる網羅的解析 (2011)
  • Author(s): 小川裕子, 武富芳隆, 村上誠, 辻本雅文, 矢ノ下良平
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
• [Presentation] マスト細胞を制御する新しい脂質マシナリー (2011)
  • Author(s): 武富芳隆, 村上誠
  • Organizer: 第84回日本生化学会大会(招待講演)
  • Place of Presentation: 京都
• [Presentation] Getting new insights into the functions of sPLA2s (2011)
  • Author(s): Murakami M, Sato H, Taketomi Y, Yamamoto K.
  • Organizer: 12th International conference "Bioactive lipids in cancer, inflammation, and related diseases"
  • Place of Presentation: Seattle, USA
• [Presentation] An adipokine-like phospholipase A2 from hypertrophied adipocytes controls lipid metabolism and obesity (2011)
  • Author(s): Sato H, Taketomi Y, Ikeda K, Arm JP, Murakami M.
  • Organizer: 12th International conference "Bioactive lipids in cancer, inflammation, and related diseases"
  • Place of Presentation: Seattle, USA
• [Presentation] Group IIF phospholipase A2 maintains epidermal homeostasis (2011)
  • Author(s): Yamamoto K, Shimo K, Miki Y, Taketomi Y, Ikeda K, Nakanishi H, Taguchi R, Gelb MH, Lambeau G, Murakami M.
  • Organizer: 12th International conference "Bioactive lipids in cancer, inflammation, and related diseases"
  • Place of Presentation: Seattle, USA
• [Presentation] Biology of group X secreted phospholipase A2: from physiology to cancer and inflammatory diseases (2011)
  • Author(s): Lambeau G, Jemel I, Escoffier J, Ait-Oufella H, Li H, Guillaume C, Gora S, Surrel F, Coatrieux C, Payre C, Tanemoto A, Taketomi Y, et al.
  • Organizer: 12th International conference "Bioactive lipids in cancer, inflammation, and related diseases"
  • Place of Presentation: Seattle, USA
• [Presentation] Roles of multiple sPLA2 enzymes in obesity, hepatic steatosis, insulin tolerance, lipoprotein metabolism and adipose inflammation (2011)
  • Author(s): Sato H, Taketomi Y, Yamamoto K, Murakami M.
  • Organizer: The 30th Naito conference on membrane dynamics and lipid biology [II]: domeins, droplets and diseases.
  • Place of Presentation: 札幌
• [Presentation] 脂肪過栄養により誘導されるsPLA2-Vは全身的な脂質代謝異常を制御する (2011)
  • Author(s): 佐藤弘泰, 武富芳隆, 山本圭, 磯貝有紀, 石川由紀雄, 石井壽晴, 原俊太郎, 村上誠
  • Organizer: 第53回日本脂質生化学会
  • Place of Presentation: 東京
• [Presentation] 外根鞘に局在するsPLA2-Xは体毛の恒常性維持に関与する (2011)
  • Author(s): 山本圭, 武富芳隆, 三木寿美, 佐藤弘泰, 池田和貴, 中西広樹, 田口良, 村上誠
  • Organizer: 第53回日本脂質生化学会
  • Place of Presentation: 東京
• [Presentation] 樹状細胞のsPLA2-IIDは炎症応答の緩解を制御する (2011)
  • Author(s): 三木寿美, 山本圭, 下華奈子, 武富芳隆, 中西広樹, 田口良, 原俊太郎, 村上誠
  • Organizer: 第53回日本脂質生化学会
  • Place of Presentation: 東京
• [Book] PLA2, 動脈硬化症の新しい診断・治療標的. 倉林正彦、山岸昌一郎編 (2012)
  • Author(s): 武富芳隆, 村上誠
  • Publisher: メディカルレビュー社
• [Book] 動脈硬化症の新しい診断・治療標的 (2012)
  • Author(s): 武富芳隆
  • Total Pages: 12
  • Publisher: メディカルレビュー社
• [Book] Phospholipase A2 as a potential target of airway diseases. Obstructive Airway Diseases: Role of Lipid Mediators. eds by Abhjit Ray (2011)
  • Author(s): Taketomi, Y., Murakami, M
  • Publisher: Taylor & Francis Group
• [Book] 脂質異常症(高脂血症), 生命科学研究の戦略:疾患モデルマウスと表現型解析 (2011)
  • Author(s): 佐藤弘泰, 武富芳隆, 山本圭, 村上誠
• [Book] Obstructive Airway Diseases: Role of Lipid Mediators (2011)
  • Author(s): Taketomi, Y., Murakami, M. Phospholipase A2 as a potential target of airway diseases.
  • Total Pages: 29
  • Publisher: Taylor & Francis Group
• [Book] 生命科学研究の戦略：疾患モデルマウスと表現型解析 (2011)
  • Author(s): 佐藤弘泰, 武富芳隆, 山本圭, 村上誠
  • Total Pages: 10
  • Publisher: 中山書店
• [Remarks] プレス発表: 東京都報道発表:体に蓄えられた魚の油が病気を止める .体に優しい脂質を動かし炎症にブレーキをかける酵素の発見.. 2013年5月24日
  • URL: http://www.metro.tokyo.jp/INET/OSHIRASE/2013/05/20n5o400.htm
• [Remarks] マイナビニュース:東京都医学研など、脂質成分が炎症にブレーキをかける仕組みを解明. 2013年5月27日
  • URL: http://news.mynavi.jp/news/2013/05/27/128/index.html
• [Remarks] ライフサイエンス 新着論文レビュー:村上誠, 武富芳隆. III型ホスホリパーゼA2.プロスタグランジンD2経路はマスト細胞の成熟を制御する. 2013年5月10日
  • URL: http://first.lifesciencedb.jp/archives/6996#more-6996
• [Remarks] マイナビニュース:花粉症などのアレルギー克服に期待 .東京都、新たな脂質代謝経路を解明. 2013年5月1日
  • URL: http://news.mynavi.jp/news/2013/05/01/113/index.html
• [Remarks] プレス発表: 東京都報道発表:アレルギーを起こす新しい脂質代謝経路を解明 .花粉症等アレルギー克服に向けての新しい創薬に期待.. 2013年4月30日
  • URL: http://www.metro.tokyo.jp/INET/OSHIRASE/2013/04/20n4u600.htm
• [Remarks] III型ホスホリパーゼ-プロスタグランジンD2経路はマスト細胞の成熟を制御する
  • URL: http://first.lifesciencedb.jp/archives/6996#more-6996
• [Remarks] アレルギーを起こす新しい脂質代謝経路を解明
  • URL: http://www.metro.tokyo.jp/INET/OSHIRASE/2013/04/20n4u600.htm
• [Remarks] アレルギーを起こす新しい脂質代謝経路を解明
  • URL: http://www.igakuken.or.jp/research/topics/2013/0430.html
• [Remarks]
  • URL: http://www.igakuken.or.jp/lipid/research7.html
• [Remarks]
  • URL: http://www.igakuken.or.jp/lipid/project_j.html
• [Remarks]
  • URL: http://www.igakuken.or.jp/lipid/research6.html
• [Patent(Industrial Property Rights)] ホスホリパーゼA2G3を指標としたスクリーニング方法 (2013)
  • Inventor(s): 村上誠、武富芳隆
  • Industrial Property Rights Holder: 村上誠、武富芳隆
  • Industrial Property Number: 2013-073775
  • Filing Date: 2013-03-29
  • Application Year: 2013