Identification of alternative pentose phosphate pathway in animals.
| Project/Area Number |
23790122
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
KONDO Yoshitaka 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (20507397)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 代謝 / 生化学 / 酵素 / 動物 / ペントースリン酸経路 / グルコン酸キナーゼ |
|---|
| Research Abstract |
In pentose phosphate pathway, glucose 6-phosphate is converted to glyceraldehyde 3-phosphate via glucono-1,5-lactone 6-phosphate and 6-phospho gluconate to produce NADPH and various hexose which is necessary for a synthesis of nucleic acid. It is known that alternative pathway from glucose to 6-phospho gluconate through gluconolactone and gluconate exists in bacteria. However, it remains unclear whether the alternative pathway exists in animals. In this study, we identified the gluconokinase gene which catalyzes a phosphorylation of gluconate to 6-phospho gluconate in human and mouse.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Senescence marker protein-30/Superoxide dismutase 1 double knockout mice exhibits increased oxidative stress and hepatic steatosis2014
Author(s)
Kondo, Y., Masutomi, H., Noda, Y., Ozawa, Y., Takahashi, T., Handa, S., Maruyama, N., Shimizu, T., and Ishigami, A
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Journal Title
FEBS Open Bio
Volume: 4
Issue: 1
Pages: 522-532
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Lepr(db/db) Mice with Senescence Marker Protein-30 Knockout (Lepr(db/db)Smp30(Y/-) ) Exhibit increases in small dense-LDL and severe fatty liver despite being fed a standard diet.2013
Author(s)
Kondo Y, Hasegawa G, Okada H, Senmaru T, Fukui M, Nakamura N, Sawada M, Kitawaki J, Okanoue T, Kishimoto Y, Amano A, Maruyama N, Obayashi H, Ishigami A
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Journal Title
PLoS One
Volume: 8
Issue: 6
Pages: 65698-65698
DOI
Related Report
Peer Reviewed
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[Journal Article] Pancreatic insulin release in vitamin C-deficient senescence marker protein-30/gluconolactonase knockout mice2012
Author(s)
Senmaru T., Yamasaki M., Okada H., Asano M., Fukui M., Nakamura N., Obayashi H., Kondo Y., Maruyama N., Ishigami A. and Hasewawa G.
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Journal Title
Journal of Clinical Biochemistry and Nutrition
Volume: 50
Issue: 2
Pages: 114-118
DOI
NAID
ISSN
0912-0009, 1880-5086
Related Report
Peer Reviewed
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[Journal Article] A significant relationship between plasma vitamin C concentration and physical performance among Japanese elderly women : Comparison in healthy Japanese subjects.2012
Author(s)
Saito K., Yokoyama T., Yoshida H., Kim H., Shimada H., Yoshida Y., Iwasa H., Shimizu Y., Kondo Y., Handa S., Maruyama N., Ishigami A. and Suzuki T.
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Journal Title
J. Gerontol. A Biol. Sci. Med. Sci.
Volume: 67(3)
Issue: 3
Pages: 295-301
DOI
Related Report
Peer Reviewed
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[Presentation] Differential effect of vitamin C deficiency on the pathogenesis of diabetic nephropathy.2012
Author(s)
Okada H., Senmaru T., Kondo Y., Ishigami A., Obayashi H., Asano M., Yamazaki M., Fukui M., Hasegawa G., Nakamura N.
Organizer
72th annual meeting and scientific sessions of American Diabetes Association
Place of Presentation
SanDiego, USA
Related Report
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