| Project/Area Number |
23790133
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
KAWAHARA Kohichi 熊本大学, 大学院・生命科学研究部, 助教 (10347015)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | アルツハイマー病 / βアミロイドペプチド / 記憶改善 / レチノイド / インターロイキン4 / ミクログリア / インターロイキン４ / ２型ミクログリア / レチノイン酸受容体 / レチノイドX受容体 / Am80 / HX630 / アミロイドβ |
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| Research Abstract |
In this study, we tried to develop seeds that stimulate the neuro-protective activities of anti-inflammatory type 2 microglia as a new strategy for treatment of Alzheimer’s disease. We focused on synthetic retinoids, because they have reported to increase IL-4 production in T-cell system. (1) Administration of the retinoids significantly improved memory deficits in APP23 mice and reduced levels of insoluble Aβ peptide in the brain. (2) IL-4 level in the hippocampus, not in the cerebral cortex, tended to increase in retinoids-treated group compared with vehicle-treated one. In addition, improvement of memory in APP23 mice after retinoid treatment was related to the IL-4 level in the hippocampus. (3) In vitro, IL-4R α was increased in murine microglial MG5 cells co-stimulated with retinoids. These findings provide information about the therapeutic potential of these agents for AD.
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