Development of a highly efficient method for generating functional antibodies based on grafting natural ligands
| Project/Area Number |
23790136
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 抗体 / ペプチド移植 / タンパク質工学 / 受容体 / 分子認識 / リガンド |
|---|
| Research Abstract |
In this study, to develop a method for generating functional antibodies, we grafted the peptide fragment, which was derived from the proteinous ligand, onto the variable region of a human antibody. As the results, we succeeded in preparing the peptide-gra
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Construction and humanization of a functional bispecific EGFR × CD16 diabody using a refolding system2012
Author(s)
Ryutaro Asano, Makoto Nakayama, Hiroko Kawaguchi, Tsuguo Kubota, Takeshi Nakanishi, Mitsuo Umetsu, Hiroki Hayashi, Yu Katayose, Michiaki Unno, Toshio Kudo, and Izumi Kumagai
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Journal Title
FEBS J
Volume: 279
Pages: 223-233
Related Report
Peer Reviewed
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[Journal Article] In vitro and in vivo antitumor effects of recombinant bispecific antibodies based on humanized anti-EGFR antibody2011
Author(s)
Yasuhiro Watanabe, Ryutaro Asano, Kyoko Arai, Ippei Shimomura, Hiromi Ogata, Hiroko Kawaguchi, Hiroki Hayashi, Hideo Ohtsuka, Hiroshi Yoshida, Yu Katayose, Shinichi Egawa, Takeshi Nakanishi, Mitsuo Umetsu, Hiroshi Yasui, Tadao Ishida, Kohzoh I
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Journal Title
Oncol. Rep
Volume: 26
Pages: 949-955
Related Report
Peer Reviewed
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