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Development of the protein-ligand docking program using multi-objective optimization and interactive optimization

Research Project

Project/Area Number 23790137
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Drug development chemistry
Research InstitutionKanazawa University (2012-2013)
Tohoku Pharmaceutical University (2011)

Principal Investigator

ODA Akifumi  金沢大学, 薬学系, 准教授 (50433511)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsインシリコ創薬 / タンパク質-リガンドドッキング / 多目的最適化 / 対話型最適化 / コンセンサススコア / 分子シミュレーション / Ligand-based drug design / スコア関数
Research Abstract

In this study, multi-objective optimization was adopted for protein-ligand docking calculations. Multiple scoring functions were simultaneously used, and the Pareto optima were selected as the solutions of docking trials. In addition, the concept of the interactive optimization was also used, because the reduction of the number of the false positives is one of the most important problems in docking calculations. In interactive optimization, false positives were eliminated by using several criterion, such as experimental data and estimated pharmacophore obtained by ligand-based approach. The combination use of multi-objective optimization and interactive optimization was tested for large test set, and was applied for actual drug design trials.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (58 results)

All 2014 2013 2012 2011 Other

All Journal Article (14 results) (of which Peer Reviewed: 11 results) Presentation (37 results) (of which Invited: 2 results) Book (3 results) Remarks (4 results)

  • [Journal Article] Evaluation of influence of single nucleotide polymorphisms in cytochrome P450 2B6 on substrate recognition using computational docking and molecular dynamics simulation2014

    • Author(s)
      K. Kobayashi, O. Takahashi, M. Hiratsuka, N. Yamaotsu, S. Hirono, Y. Watanabe, A. Oda
    • Journal Title

      PLOS ONE

      Volume: 9(5) Issue: 5 Pages: 96789-96789

    • DOI

      10.1371/journal.pone.0096789

    • Related Report
      2013 Final Research Report
  • [Journal Article] Multi-objective Optimizations for Selections of Protein-Ligand Docking Poses using Pareto Optima as a Consensus Score2014

    • Author(s)
      Akifumi Oda, Shuichi Fukuyoshi, Ryoichi Nakagaki, Ohgi Takahashi
    • Journal Title

      JPS Conference Proceedings

      Volume: 1 Pages: 16005-16005

    • DOI

      10.7566/jpscp.1.016005

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 結合型D-アミノ酸についての計算機的研究2014

    • Author(s)
      小田彰史
    • Journal Title

      D-アミノ酸学会誌

      Volume: 2(1) Pages: 1-6

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Effects of initial settings on computational protein-ligand docking accuracies for several docking programs2014

    • Author(s)
      Akifumi Oda, Noriyuki Yamaotsu, Shuichi Hirono, Yurie Watanabe, Shuichi Fukuyoshi, Ohgi Takahashi
    • Journal Title

      Molecular Simulation

      Volume: 40

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Evaluation of influence of single nucleotide polymorphisms in cytochrome P450 2B6 on substrate recognition using computational docking and molecular dynamics simulation2014

    • Author(s)
      Kana Kobayashi, Ohgi Takahashi, Masahiro Hiratsuka, Noriyuki Yamaotsu, Shuichi Hirono, Yurie Watanabe, Akifumi Oda
    • Journal Title

      PLOS ONE

      Volume: 9

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Prediction of [GADV]-Proteins Using Threading and Ab initio Modeling for Investigations of the Origin of Life2013

    • Author(s)
      小田彰史、福吉修一、中垣良一
    • Journal Title

      Journal of Computer Aided Chemistry

      Volume: 14 Issue: 0 Pages: 23-35

    • DOI

      10.2751/jcac.14.23

    • NAID

      130004428037

    • ISSN
      1345-8647
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Determination of AMBER Force Field Parameters for Thioester by Quantum Chemical Calculations2013

    • Author(s)
      Akifumi Oda, Shuichi Fukuyoshi, Ryoichi Nakagaki, and Ohgi Takahashi
    • Journal Title

      Chemistry Letters

      Volume: 42 Issue: 10 Pages: 1206-1208

    • DOI

      10.1246/cl.130517

    • NAID

      10031201311

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluations of the conformational search accuracy of CAMDAS using experimental three-dimensional structures of protein-ligand complexes2013

    • Author(s)
      A. Oda, N. Yamaotsu, S. Hirono, Y. Takano, S. Fukuyoshi, R. Nakagaki, O. Takahashi
    • Journal Title

      J. Phys. : Conf. Ser

      Volume: 454 Pages: 12028-12028

    • DOI

      10.1088/1742-6596/454/1/012028

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Computational studies on the repair mechanism of peptides including isomerized aspartic acid residues by protein L-isoaspartyl (D-aspartyl) O-methyltransferase2012

    • Author(s)
      A. Oda, I. Noji, K. Kobayashi, S. Fukuyoshi, Nakagaki, O. Takahashi
    • Journal Title

      Peptide Sci

      Pages: 253-256

    • NAID

      10031161619

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of Androgen Recby Application of Ten-vertex p-Carborane as a Novel Hydrophobic Core Structure2012

    • Author(s)
      Shinya Fujii, Kiminori Ohta, Tokuhito Goto, Akifumi Oda, Hiroyuki Masuno, Ysuyuki Endo, Hiroyuki Kagechika
    • Journal Title

      Med. Chem. Commun

      Volume: 3 Issue: 6 Pages: 680-684

    • DOI

      10.1039/c2md00294a

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Romidepsin (FK228) and its analogs directly inhibit PI3K activity and potently induce apoptosis as HDAC/PI3K dual inhibitors2012

    • Author(s)
      Ken Saijo, Tadashi Katoh, Hideki Shimodaira, Akifumi Oda, Ohgi Takahashi, Chikashi Ishioka
    • Journal Title

      Cancer Science

      Volume: 103 Issue: 11 Pages: 1994-2001

    • DOI

      10.1111/cas.12002

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Computational Studies on the Repair Mechanism of Peptides Including Isomerized Aspartic Acid Residues by Protein L-Isoaspartyl (D-Aspartyl) O-Methyltransferase2012

    • Author(s)
      Akifumi Oda, Ikuhiko Noji, Kana Kobayashi, Shuichi Fukuyoshi, Ryoichi Nakagaki, Ohgi Takahashi
    • Journal Title

      Peptide Science

      Volume: 2012 Pages: 253-256

    • NAID

      10031161619

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] FADおよびFADH2存在下におけるD-アスパラギン酸酸化酵素とD-アスパラギン酸のドッキングシミュレーション2011

    • Author(s)
      小林佳奈, 村上知之, 吉田崇志, 小田彰史, 高橋央宜
    • Journal Title

      東北薬科大学研究誌

      Volume: 58 Pages: 35-40

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of initial settings on computational protein-ligand docking accuracies for several docking programs

    • Author(s)
      A. Oda, N. Yamaotsu, S. Hirono, Y. Watanabe, S. Fukuyoshi, O. Takahashi
    • Journal Title

      Mol. Simul

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] PI3KがHDAC阻害剤ロミデプシンを認識する機構の分子動力学シミュレーションによる解析2014

    • Author(s)
      小田彰史,西條憲,石岡千加史,加藤正,福吉修一,中垣良一,高橋央宜
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学(熊本)
    • Year and Date
      2014-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of Initial Settings on Computational Protein-Ligand Docking Accuracies for several Docking Programs2013

    • Author(s)
      A. Oda, N. Yamaotsu, S. Hirono, Y. Watanabe, Fukuyoshi, R. Nakagaki, O. Takahashi
    • Organizer
      3rd International Conference on Molecular Simulation
    • Place of Presentation
      Kobe International Conference Center(Kobe)
    • Year and Date
      2013-11-18
    • Related Report
      2013 Final Research Report
  • [Presentation] タンパク質中D-アミノ酸残基のin silico解析2013

    • Author(s)
      小田彰史
    • Organizer
      ERATO浅野プロジェクト講演会・酵素化学工学セミナー
    • Place of Presentation
      富山県立大学(射水)
    • Year and Date
      2013-11-01
    • Related Report
      2013 Final Research Report
  • [Presentation] チオエステル周辺のAMBER力場の開発および評価2013

    • Author(s)
      小田彰史,福吉修一,中垣良一,高橋央宜
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2013-10-29
    • Related Report
      2013 Final Research Report
  • [Presentation] タンパク質中に残基として含まれるD-アミノ酸をコンピュータで取り扱う2013

    • Author(s)
      小田彰史
    • Organizer
      第9回D-アミノ酸研究会学術講演会
    • Place of Presentation
      関西大学(吹田)
    • Year and Date
      2013-09-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Computational studies on substrate recognition mechanism of protein L-soaspartyl (D-aspartyl) O-methyltransferase2013

    • Author(s)
      A. Oda, I. Noji, K. Kobayashi, S. Fukuyoshi, R. Nakagaki, O. Takahashi
    • Organizer
      International Conference on Structural Genomics 2013 -Structural Life Science-
    • Place of Presentation
      Keio Plaza Hotel Sapporo(Sapporo)
    • Year and Date
      2013-07-31
    • Related Report
      2013 Final Research Report
  • [Presentation] Novel consensus scoring strategy for evaluations of protein-ligand docking poses using multiobjective optimization2013

    • Author(s)
      A. Oda, S. Fukuyoshi, R. Nakagaki, O. Takahashi
    • Organizer
      The 12th Asia Pacific Physics Conference
    • Place of Presentation
      Makuhari Messe(Chiba)
    • Year and Date
      2013-07-16
    • Related Report
      2013 Final Research Report
  • [Presentation] PI3KがHDAC阻害剤ロミデプシンを認識する機構についてリガンドベース手法と構造ベース手法を組み合わせて計算機的に解明する2013

    • Author(s)
      小田彰史,西條憲,石岡千加史,加藤正,福吉修一,中垣良一,高橋央宜
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2013-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Evaluations of conformational search accuracy of CAMDAS using experimental three-dimensional structures of protein-ligand complexes2012

    • Author(s)
      A. Oda, N. Yamaotsu, S. Hirono, Y. Takano, S. Fukuyoshi, R. Nakagaki, O. Takahashi
    • Organizer
      Conference on Computational Physics 2012
    • Place of Presentation
      Nichii Gakkan conference center(Kobe)
    • Year and Date
      2012-10-17
    • Related Report
      2013 Final Research Report
  • [Presentation] タンパク質-リガンドドッキングにおける多目的最適化の有用性の評価2012

    • Author(s)
      小田彰史,高橋央宜,福吉修一,中垣良一
    • Organizer
      日本コンピュータ化学会2012秋季年会
    • Place of Presentation
      山形大学(山形)
    • Year and Date
      2012-10-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 残基としてD-アミノ酸を含む系の分子力学計算のための力場パラメータの評価2012

    • Author(s)
      小田彰史,高橋央宜
    • Organizer
      第12回日本蛋白質科学会年会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2012-06-22
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒトPIMTがL-β-AspとD-α-Aspの両方を認識する機構についての計算機的研究2012

    • Author(s)
      小田彰史,小林佳奈,高橋央宜
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2012-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Prediction of the complex structure between PI3K and romidepsin (FK-228) for drug design of PI3K/HDAC dual inhibitors2012

    • Author(s)
      A. Oda, K. Saijo, C. Ishioka, T. Katoh, S. Fukuyoshi, R. Nakagaki, O. Takahashi
    • Organizer
      生命医薬情報学連合大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2013 Final Research Report
  • [Presentation] Prediction of the Complex Structure between PI3K and Romidepsin (FK-228) for Drug Design of PI3K/HDAC Dual Inhibitors2012

    • Author(s)
      Akifumi Oda, Ken Saijo, Chikashi Ishioka, Tadashi Katoh, Shuichi Fukuyoshi, Ryoichi Nakagaki, Ohgi Takahashi
    • Organizer
      生命医薬情報学連合大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] 異性化アスパラギン酸を含むペプチドに対する分子力学計算の妥当性の評価2011

    • Author(s)
      小田彰史,小林佳奈,高橋央宜
    • Organizer
      第39回構造活性相関シンポジウム
    • Place of Presentation
      東京理科大学(野田)
    • Year and Date
      2011-11-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Pareto optimal consensus score for evaluations of protein-ligand complex structures2011

    • Author(s)
      A. Oda, O. Takahashi
    • Organizer
      CBI/JSBi 2011
    • Place of Presentation
      Kobe international conference center(Kobe)
    • Year and Date
      2011-11-08
    • Related Report
      2013 Final Research Report
  • [Presentation] アミノ酸残基の立体反転についての計算機的研究2011

    • Author(s)
      小田彰史
    • Organizer
      2011年度CACフォーラム一泊研修会
    • Place of Presentation
      リゾーピア熱海(熱海)
    • Year and Date
      2011-10-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 非金属元素に対する高次項を含んだ電荷平衡法2011

    • Author(s)
      小田彰史,小林佳奈,高橋央宜
    • Organizer
      平成23年度化学系学協会東北大会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2011-09-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Validation of quantum chemical methods for geometrical optimizations of sulfonamide derivatives2011

    • Author(s)
      A. Oda, Y. Takano, O. Takahashi
    • Organizer
      XVIth International Workshop on Quantum Systems in Chemistry and Physics
    • Place of Presentation
      Ishikawa Prefecture Museum of Art(Kanazawa)
    • Related Report
      2013 Final Research Report
  • [Presentation] PI3KがHDAC阻害剤ロミデプシンを認識する機構の分子動力学シミュレーションによる解析

    • Author(s)
      小田彰史、西條憲、石岡千加史、加藤正、福吉修一、中垣良一、高橋央宜
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市総合体育館(熊本)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of Initial Settings on Computational Protein-Ligand Docking Accuracies for several Docking Programs

    • Author(s)
      Akifumi Oda, Noriyuki Yamaotsu, Shuichi Hirono, Yurie Watanabe, Shuichi Fukuyoshi, Ryoichi Nakagaki, Ohgi Takahashi
    • Organizer
      3rd International Conference on Molecular Simulation
    • Place of Presentation
      Kobe International Conference Center (Kobe)
    • Related Report
      2013 Annual Research Report
  • [Presentation] タンパク質中D-アミノ酸残基のin silico解析

    • Author(s)
      小田彰史
    • Organizer
      ERATO浅野プロジェクト講演会・酵素化学工学セミナー
    • Place of Presentation
      富山県立大学(射水)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] チオエステル周辺のAMBER力場の開発および評価

    • Author(s)
      小田彰史, 福吉修一, 中垣良一, 高橋央宜
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      京都国際会議場(京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] TEDB-TB analogs as new classes of tubulin inhibitors

    • Author(s)
      Kyoko Nakagawa-Goto, Akifumi Oda, Ernest Hamel, Emika Ohkoshi, Bastow F Kenneth, Kuo-Hsiung Lee, Masuo Goto
    • Organizer
      246th ACS National Meeting
    • Place of Presentation
      Indiana Convention Center (Indianapolis)
    • Related Report
      2013 Annual Research Report
  • [Presentation] タンパク質中に残基として含まれるD-アミノ酸をコンピュータで取り扱う

    • Author(s)
      小田彰史
    • Organizer
      第9回D-アミノ酸研究会学術講演会
    • Place of Presentation
      関西大学(吹田)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Computational studies on substrate recognition mechanism of protein L-isoaspartyl (D-aspartyl) O-methyltransferase

    • Author(s)
      Akifumi Oda, Ikuhiko Noji, Kana Kobayashi, Shuichi Fukuyoshi, Ryoichi Nakagaki, Ohgi Takahashi
    • Organizer
      International Conference on Structural Genomics 2013 -Structural Life Science-
    • Place of Presentation
      Keio Plaza Hotel Sapporo (Sapporo)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Novel consensus scoring strategy for evaluations of protein-ligand docking poses using multiobjective optimization

    • Author(s)
      A. Oda, S. Fukuyoshi, R. Nakagaki, O. Takahashi
    • Organizer
      The 12th Asia Pacific Physics Conference
    • Place of Presentation
      Makuhari Messe (Chiba)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 残基としてD-アミノ酸を含む系の分子力学計算のための力場パラメータの評価

    • Author(s)
      小田彰史、高橋央宜
    • Organizer
      第12回日本蛋白質科学会年会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Research-status Report
  • [Presentation] タンパク質-リガンドドッキングにおける多目的最適化の有用性の評価

    • Author(s)
      小田彰史、高橋央宜、福吉修一、中垣良一
    • Organizer
      日本コンピュータ化学会2012秋季年会
    • Place of Presentation
      山形大学(山形県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Evaluations of conformational search accuracy of CAMDAS using experimental three-dimensional structures of protein-ligand complexes

    • Author(s)
      A. Oda, N. Yamaotsu, S. Hirono, Y. Takano, S. Fukuyoshi, R. Nakagaki, O. Takahashi
    • Organizer
      Conference on Computational Physics 2012
    • Place of Presentation
      Nichii Gakkan conference center(兵庫県)
    • Related Report
      2012 Research-status Report
  • [Presentation] PI3KがHDAC阻害剤ロミデプシンを認識する機構についてリガンドベース手法と構造ベース手法を組み合わせて計算機的に解明する

    • Author(s)
      小田彰史、西條憲、石岡千加史、加藤正、福吉修一、中垣良一、高橋央宜
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Validation of quantum chemical methods for geometrical optimizations of sulfonamide derivatives

    • Author(s)
      Akifumi Oda, Yu Takano and Ohgi Takahashi
    • Organizer
      XVIth International Workshop on Quantum Systems in Chemistry and Physics
    • Place of Presentation
      Ishikawa Prefecture Museum of Art (Kanazawa)
    • Related Report
      2011 Research-status Report
  • [Presentation] 非金属元素に対する高次項を含んだ電荷平衡法

    • Author(s)
      小田彰史, 小林佳奈, 高橋央宜
    • Organizer
      平成23年度化学系学協会東北大会
    • Place of Presentation
      東北大学(仙台)
    • Related Report
      2011 Research-status Report
  • [Presentation] アミノ酸残基の立体反転についての計算機的研究

    • Author(s)
      小田彰史
    • Organizer
      2011年度CACフォーラム一泊研修会(招待講演)
    • Place of Presentation
      リゾーピア熱海(熱海)
    • Related Report
      2011 Research-status Report
  • [Presentation] Pareto optimal consensus score for evaluations of protein-ligand complex structures

    • Author(s)
      Akifumi Oda, Ohgi Takahashi
    • Organizer
      CBI/JSBi 2011
    • Place of Presentation
      Kobe international conference center (Kobe)
    • Related Report
      2011 Research-status Report
  • [Presentation] 異性化アスパラギン酸を含むペプチドに対する分子力学計算の妥当性の評価

    • Author(s)
      小田彰史, 小林佳奈, 高橋央宜
    • Organizer
      第39回構造活性相関シンポジウム
    • Place of Presentation
      東京理科大学(野田)
    • Related Report
      2011 Research-status Report
  • [Presentation] ヒトPIMTがL-β-AspとD-α-Aspの両方を認識する機構についての計算機的研究

    • Author(s)
      小田彰史, 小林佳奈, 高橋央宜
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌)
    • Related Report
      2011 Research-status Report
  • [Book] Theory, Kinetics and Implementation (D. E. Garcia, et al., Eds.), chapter 22012

    • Author(s)
      A. Oda, et al
    • Publisher
      Nova Science Publishers, Inc.
    • Related Report
      2013 Final Research Report
  • [Book] Quantum Systems in Chemistry and Physics: Progress in Methods and Applications (K. Nishikawa, et al., Eds.), chapter 172012

    • Author(s)
      A. Oda, et al
    • Related Report
      2013 Final Research Report
  • [Book] Quantum Systems in Chemistry and Physics: Progress in Methods and Applications2012

    • Author(s)
      Akifumi Oda, Yu Takano, Ohgi Takahashi
    • Publisher
      Springer Science+Business Media B.V.
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.p.kanazawa-u.ac.jp/~bukka/

    • Related Report
      2013 Final Research Report
  • [Remarks] 金沢大学 活性相関物理化学研究室

    • URL

      http://www.p.kanazawa-u.ac.jp/~bukka/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 金沢大学医薬保健研究域薬学系 活性相関物理化学研究室

    • URL

      http://www.p.kanazawa-u.ac.jp/~bukka/

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.tohoku-pharm.ac.jp/laboratory/yakuhinb/

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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