Synthesis and anti-viral evaluation of 4'-substituted nucleoside derivatives
Project/Area Number |
23790141
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Drug development chemistry
|
Research Institution | Showa University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 生物活性物質 / ヌクレオシド誘導体 / 抗ウイルス化合物 / 核酸誘導体 / 抗腫瘍化合物 |
Research Abstract |
With an aim to discovery of novel anti-viral/tumor agents, I have developed a new method for the synthesis of 4’-substituted cordycepin derivatives by substitution of a phenylsulfanyl leaving group. Anti-viral evaluation of 4’-substituted cordycepin found some compounds having an activity against RNA virus.
|
Report
(3 results)
Research Products
(7 results)