| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Research Abstract |
RNA function is controlled by post-transcriptional modification. Therefore, there is increasing demand for methods of the site-specific modifications of RNA because of potential applications as biological tools and therapeutic methods. In this research, we are developing site-specific RNA modification tool using cross-linking forming oligonucleotide. We have found that the 6-vinylpurine newly designed in the current study serves well as a new nucleobase for increasing cross-link reactivity to target cytosine.
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