Development of novel glycolipids that activates lymphocytes to induce anticancer activity
| Project/Area Number |
23790148
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Drug development chemistry
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
TASHIRO Takuya 独立行政法人理化学研究所, 免疫制御研究グループ, 研究員 (20339104)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | alpha-GalCer / CD1d / glycosphingolipid / IFN-gamma / Natural killer T cell / ナチュラルキラーT細胞 / インターフェロンガンマ / スフィンゴ糖脂質 / サイトカイン / 構造活性相関 / α-GalCer / T細胞受容体 / KRN7000 / GalCer |
|---|
| Research Abstract |
KRN7000, an alpha-galactosylated sphingolipid, stimulates natural killer T cells to induce antitumor activity. Based on the X-ray crystallographic analysis of CD1d/KRN7000/TCR, structure-activity relationship study on the 6-hydroxyl group of the galactose part of KRN7000 was performed. We synthesized several 6’’-carbamate analogs of KRN7000. It was found that these analogs were potent immunostimulants, and induced a large amount of IFN-gamma production in vivo (mouse).
|
Report
(3 results)
Research Products
(28 results)
-
-
-
-
-
-
-
[Journal Article] First synthesis of decaturin C, an antiinsectant diterpenoid isolated from Penicillium thiersii.2012
Author(s)
Nakazaki, K., Hayashi, K., Hosoe, S., Tashiro, T., Kuse, M., and Takikawa, H.
-
Journal Title
Tetrahedron
Volume: 68
Issue: 44
Pages: 9029-9034
DOI
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] RCAI-39, 41, 53, 100, 127 and 128, the analogues of KRN7000, activate mouse natural killer T cells to produce Th2-biased cytokines by their administration as liposomal particles2011
Author(s)
Takuya Tashiro, Yasuyuki Ishii, Tomokuni Shigeura, Ryusuke Nakagawa, Hiroshi Watarai, Masaru Taniguchi, Kenji Mori
-
Journal Title
Med. Chem. Commun.
Volume: 2
Issue: 7
Pages: 620-625
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
