| Project/Area Number |
23790148
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
TASHIRO Takuya 独立行政法人理化学研究所, 免疫制御研究グループ, 研究員 (20339104)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | alpha-GalCer / CD1d / glycosphingolipid / IFN-gamma / Natural killer T cell / ナチュラルキラーT細胞 / インターフェロンガンマ / スフィンゴ糖脂質 / サイトカイン / 構造活性相関 / α-GalCer / T細胞受容体 / KRN7000 / GalCer |
|---|
| Research Abstract |
KRN7000, an alpha-galactosylated sphingolipid, stimulates natural killer T cells to induce antitumor activity. Based on the X-ray crystallographic analysis of CD1d/KRN7000/TCR, structure-activity relationship study on the 6-hydroxyl group of the galactose part of KRN7000 was performed. We synthesized several 6’’-carbamate analogs of KRN7000. It was found that these analogs were potent immunostimulants, and induced a large amount of IFN-gamma production in vivo (mouse).
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