Study on nutritional signalings regulating the intestinal organelles in C. elegans
| Project/Area Number |
23790154
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental pharmacy
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 栄養シグナル / オルガネラ / 線虫 / 飢餓 / インスリン |
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| Research Abstract |
The granular organelles that fill the C. elegans intestinal cells at the young adult stage deteriorate rapidly by food deprivation. This phenomenon also occurs in the mutant worms defective of the lysosome formation, suggesting that the deterioration is not dependent on autophagy and lysosome. The analyses of the nutritional signalings regulating the organelle revealed that the organelle requires a heat-labile hydrophobic nutrient for its formation and/or maintenance, and that the insulin/insulin-like growth factor signaling modulates the organelle. Furthermore, the multiple genetic factors regulating the formation, maintenance and/or deterioration of the organelle were identified by genetic screening using the RNA interference technique.
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Report
(4 results)
Research Products
(38 results)
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[Presentation] Physical interaction of half ABC transporters HAF-4 and HAF-9, which are required for the biogenesis of the intestinal lysosome-related organelles in Caenorhabditis elegans.2012
Author(s)
Takahiro Tanji, Kenji Nishikori, Hirohisa Shiraishi, Masatomo Maeda, Ayako Ohashi-Kobayashi
Organizer
Aging, Metabolism, Stress, Pathogenesis, and Small RNAs in C. elegans Topic Meeting 2012
Place of Presentation
University of Wisconsin, Madison, WI, USA
Related Report
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[Presentation] Age-dependent alteration of major large intestinal granules in Caenorhabditis elegans.2012
Author(s)
Kenji Nishikori, Takahiro Tanji, Eisuke Kuroda, Yuki Ueda, Hirohisa Shiraishi, Ayako Ohashi-Kobayashi
Organizer
Aging, Metabolism, Stress, Pathogenesis, and Small RNAs in C. elegans Topic Meeting 2012
Place of Presentation
University of Wisconsin, Madison, WI, USA
Related Report
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