| Project/Area Number |
23790155
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ヘリコバクターハイルマニイ / 胃 MALT リンパ腫 / 細菌 / 微生物 / ヘリコバクター / ハイルマニイ / MALTリンパ腫 / H. heilmannii |
|---|
| Research Abstract |
In this study, we identified the molecular mechanism of gastric MALT lymphoma formation by infection with H. heilmannii. The results showed that the induced expression of several genes in CD86-dependent B cell activation pathway was observed. In this gastric mucosa, CTLA4, which is potent inhibitory receptor of CD80/86 dependent inflammation signal, is not induced regardless the chronic inflammation, resulting MALT lymphoma formation. In addition, we also demonstrated IL-10 is a crucial factor in this MALT lymphoma formation.
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