Molecular mechanism of gastric MALT lymphoma formation by infectionwith H. heilmannii
| Project/Area Number |
23790155
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Environmental pharmacy
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | ヘリコバクターハイルマニイ / 胃 MALT リンパ腫 / 細菌 / 微生物 / ヘリコバクター / ハイルマニイ / MALTリンパ腫 / H. heilmannii |
|---|
| Research Abstract |
In this study, we identified the molecular mechanism of gastric MALT lymphoma formation by infection with H. heilmannii. The results showed that the induced expression of several genes in CD86-dependent B cell activation pathway was observed. In this gastric mucosa, CTLA4, which is potent inhibitory receptor of CD80/86 dependent inflammation signal, is not induced regardless the chronic inflammation, resulting MALT lymphoma formation. In addition, we also demonstrated IL-10 is a crucial factor in this MALT lymphoma formation.
|
Report
(3 results)
Research Products
(12 results)
-
-
-
-
-
-
-
-
[Presentation] Induced expression of CD86 in gastric MALT lymphoma by Helicobacter heilmannii infection
Author(s)
Takahashi, T., Matsui, H., Takizawa, A.,Takahashi, S.,Hibi T., Nakamura, M., Tsuchimoto, K.
Organizer
Digestive Disease Week 2009
Place of Presentation
San Diego, USA
Related Report
-
-
-
-
