Analysis of environmental stress induced deafness

• Project/Area Number: 23790160
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental pharmacy
• Research Institution: Chubu University
• Principal Investigator: OHGAMI Nobutaka 中部大学, 生命健康科学部, 講師 (80424919)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 環境ストレス / 加齢性難聴 / 内耳 / ラセン神経節 / 難聴

Research Abstract

About 30% of the 120 million people who suffer from congenital (early-onset) hearing loss are syndromic, and the remaining 70% are non-syndromic worldwide. At present, however, no effective therapies for deafness have been established except for cochlear implantation. We have recently shown that complete impairment of Y1062-phoshorylation in c-Ret causes congenital deafness in homozygous c-Ret Y1062F knock-in mice (c-Ret-KIY1062F/Y1062F-mice). On the other hand, there is no information about the relevance between c-Ret and age-related hearing loss. In this study, we used heterozygous c-Ret Y1062F knock-in mice (c-Ret-KIY1062F/+-mice) in order to analyze whether partial impairment of Y1062-phoshorylation inc-Ret causes age-related hearing loss. This study suggests that partial impairment of c-Ret causesage-related hearing loss involving neurodegeneration of spiral ganglion neurons in mice.

Research Products

• [Journal Article] Hearing impairments caused by genetic and environmental factors. (2013)
  • Author(s): Ohgami N
  • Journal Title: Environ Health Prev Med Volume: 18 Pages: 10-15
  • NAID: 10031143686
  • Peer Reviewed
• [Journal Article] RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy. (2012)
  • Author(s): Yajima, I., Kumasaka, M.Y., Thang, N.D.,Goto, Y., Takeda, K., Yamanoshita, O., Iida,M., Ohgami, N., Tamura, H., Kawamoto,Y., Kato, M.
  • Journal Title: Dermatol. Res. Pract. Volume: 2012 Pages: 354191-354191
  • Peer Reviewed
• [Journal Article] A novel hairless mouse model for malignant melanoma. (2012)
  • Author(s): Thang, N.D., Yajima, I., Nakagawa,K., Tsuzuki, T., Kumasaka, M.Y., Ohgami, N., Ly, T.B., Iwamoto, T., Watanabe, D., Kato, M.
  • Journal Title: J. Dermatol. Sci Volume: 65 Pages: 207-212
  • Peer Reviewed
• [Journal Article] c-Ret-mediated hearing losses. (2012)
  • Author(s): Ohgami, N., Tamura, H., Ohgami, K., Iida, M., Yajima, I., Kumasaka, Y.M., Goto, Y., Sone, M., Nakashima, T., Kato, M.
  • Journal Title: Int. J. Clin. Exp. Pathol. Volume: 5 Pages: 23-28
  • Peer Reviewed
• [Journal Article] Partial impairment of c-Ret at tyrosine1062 accelerates age-related hearing loss in mice. (2012)
  • Author(s): Ohgami, N., Ida-Eto, M., Sakashita, N., Sone, M., Nakashima, T., Tabuchi, K., Hoshino, T., Shimada, A., Tsuzuki, T., Yamamoto, M., Sobue, G., Jijiwa, M., Asai, N., Hara, A., Takahashi, M., Kato, M.
  • Journal Title: Neurobiol. Aging Volume: 33
  • Peer Reviewed
• [Journal Article] Chronic exposure to low frequency noise at moderate levels causes impaired balance in mice. (2012)
  • Author(s): Tamura, H., Ohgami, N., Yajima, I., Iida, M., Ohgami, K., Fujii, N., Itabe, H., Kusudo, T., Yamashita, H., Kato, M.
  • Journal Title: PLoS ONE. Volume: 7
  • Peer Reviewed
• [Journal Article] Hearing impairments caused by genetic and environmental factors. (2012)
  • Author(s): Ohgami, N., Iida, M., Yajima, I., Tamura, H., Ohgami, K., Kato, M.
  • Journal Title: Environmental Health and Preventive Medicine Volume: 18 Pages: 10-15
  • NAID: 10031143686
  • Peer Reviewed
• [Journal Article] Exposure to low-dose barium by drinking water causes hearing loss in mice. (2012)
  • Author(s): Ohgami, N., Hori, S., Ohgami, K., Tamura, H., Tsuzuki, T., Ohnuma, S., Kato, M.
  • Journal Title: NeuroToxicology Volume: 33 Pages: 1276-1283
  • Peer Reviewed
• [Journal Article] Chronic exposure to low frequency noise at moderate levels causes impaired balance in mice. (2012)
  • Author(s): Tamura H
  • Journal Title: PLoS ONE Volume: 7
  • Peer Reviewed
• [Journal Article] Functional analysis of GNG2 in human malignant melanoma cells. (2012)
  • Author(s): Yajima I
  • Journal Title: J Dermatol Sci Volume: 68 Pages: 172-178
  • Peer Reviewed
• [Journal Article] RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy. (2012)
  • Author(s): Yajima I
  • Journal Title: Dermatol Res Pract Volume: 2012 Pages: 354191-354191
  • Peer Reviewed
• [Journal Article] Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice. (2012)
  • Author(s): Ohgami N
  • Journal Title: Neurobiology of Aging Volume: 33(3)
  • Peer Reviewed
• [Journal Article] A novel hairless mouse model for malignant melanoma. (2012)
  • Author(s): Thang ND
  • Journal Title: J Dermatol Sci Volume: 65(3) Pages: 207-212
  • Peer Reviewed
• [Journal Article] c-Ret-mediated hearing losses. (2012)
  • Author(s): Ohgami N
  • Journal Title: Int J Clin Exp Pathol Volume: 5(1) Pages: 23-28
  • Peer Reviewed
• [Journal Article] L-cysteine as a regulator for arsenic-mediated cancer-promoting and anti-cancer effects. (2011)
  • Author(s): Kato, M., Kumasaka, M.Y., Takeda, K., Hossain, K., Iida, M., Goto, Y., Ohgami, N.
  • Journal Title: Toxicol. In Vitro Volume: 25 Pages: 623-629
  • Peer Reviewed
• [Journal Article] Partial requirement of endothelin receptor B in spiral ganglion neurons for postnatal development of hearing. (2011)
  • Author(s): Ida-Eto, M., Ohgami, N., Iida, M., Yajima, I., Kumasaka, M.Y., Takaiwa, K., Kimitsuki, T., Sone, M., Nakashima, T., Tsuzuki, T., Komune, S., Yanagisawa, M., Kato, M.
  • Journal Title: J. Biol. Chem. Volume: 286 Pages: 29621-29626
  • Peer Reviewed
• [Journal Article] Molecular Network Associated with MITF in Skin Melanoma Development and Progression. (2011)
  • Author(s): Yajima, I., Kumasaka, M.Y., Thang, N.D., Goto, Y., Takeda, K., Iida, M., Ohgami, N., Tamura, H., Yamanoshita, O., Kawamoto, Y., Furukawa, K., Kato, M.
  • Journal Title: J. Skin Cancer Volume: 2011 Pages: 730170-730170
  • Peer Reviewed
• [Journal Article] Partial requirement of endothelin receptor B in spiral ganglion neurons for postnatal development of hearing. (2011)
  • Author(s): Ida-Eto M, Ohgami N
  • Journal Title: J Biol Chem Volume: 286 Pages: 29621-29626
  • Peer Reviewed
• [Journal Article] Molecular Network Associated with MITF in Skin Melanoma Development and Progression. (2011)
  • Author(s): Yajima I
  • Journal Title: J Skin Cancer Volume: 2011 Pages: 730170-730170
  • Peer Reviewed
• [Presentation] 低周波騒音曝露による平衡感覚異常の解析 (2013)
  • Author(s): 大神信孝 、田村青鳥、飯田真智子、矢 嶋伊知朗、加藤昌志
  • Organizer: 第12回分子予防環境医学研究会
  • Place of Presentation: 筑波
  • Year and Date: 2013-02-12
• [Presentation] 飲水投与した低用量バリウムの聴覚系への影響 (2013)
  • Author(s): 大神信孝、飯田真智子、加藤昌志
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] 動物モデルを用いた非熱的大気圧プラズマによる抗腫瘍効果の検討 (2013)
  • Author(s): 飯田真智子、矢嶋伊知朗、中川薫、大神 信孝 、近藤 博基、竹田圭吾、堀勝、加納 浩之、加藤昌志
  • Organizer: 第83回日本衛生学会総会
  • Place of Presentation: 金沢
• [Presentation] 飲水投与した低用量バリウムの聴覚系疾患への影響 (2013)
  • Author(s): 大神信孝 、飯田真智子、加藤昌志
  • Organizer: 第83回日本衛生学会総会
  • Place of Presentation: 金沢
• [Presentation] 飲水投与した低用量バリウムの聴覚系疾患への影響 (2013)
  • Author(s): 大神信孝
  • Organizer: 第83回日本衛生学会総会
  • Place of Presentation: 金沢大学（金沢）
• [Presentation] 飲水投与した低用量バリウムの聴覚系への影響 (2013)
  • Author(s): 大神信孝
  • Organizer: 第133回日本薬学会年会
  • Place of Presentation: パシフィコ横浜（横浜）
• [Presentation] Analysis of molecular targets expressed in spiral ganglion neurons to prevent hearing losses (2012)
  • Author(s): Ohgami, N.
  • Organizer: Department seminar at Dept. of Biochemistry
  • Place of Presentation: Dartmouth Medical School (NH, USA)
  • Year and Date: 2012-08-24
• [Presentation] 皮膚メラニンと日光曝露による酸化ストレスとの関連 (2012)
  • Author(s): 飯田真智子、矢嶋伊知朗、大神信孝、田巻満里絵、加藤昌志
  • Organizer: 第24回日本色素細胞学会学術大会
  • Place of Presentation: 長浜
• [Presentation] Analysis of endothelin receptor B expressed in spiral ganglion neurons (2012)
  • Author(s): 大神信孝 、飯田真智子、矢嶋伊知朗、加藤昌志
  • Organizer: 第24回日本色素細胞学会学術大会
  • Place of Presentation: 長浜
• [Presentation] 低周波騒音が平衡感覚に与える影響 (2012)
  • Author(s): 大神信孝 、田村青鳥、飯田真智子、矢 嶋伊知朗、加藤昌志
  • Organizer: フォーラム 2012:衛生薬学・環境トキシコロジー名古屋
• [Presentation] Environmental stress-related diseases-Noise-induced physiological impairments- (2012)
  • Author(s): Ohgami, N.
  • Organizer: The 3rd International Symposium of Environmental Health Sciences in Hanoi
  • Place of Presentation: Vietnam, Hanoi University of Technology (Hanoi, Vietnam)
• [Presentation] 環境ストレスと関連する聴覚系疾患の解析 (2012)
  • Author(s): 大神信孝 、田村青鳥、飯田真智子、加 藤昌志
  • Organizer: 第132回日本薬学会年会
  • Place of Presentation: 札幌
• [Presentation] 環境ストレスと関連する聴覚系疾患の解析 (2012)
  • Author(s): 大神信孝
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都
• [Presentation] 低周波騒音が平衡感覚に与える影響の解析 (2012)
  • Author(s): 田村青鳥 、大神信孝 、加藤昌志
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都
• [Presentation] Endothelin receptor B in spiral ganglion neurons partially contributes to postnatal development of hearing. (2012)
  • Author(s): 大神信孝
  • Organizer: 第35回日本神経科学大会 / Neuroscience2012
  • Place of Presentation: 名古屋国際会議場 (名古屋)
• [Presentation] 環境ストレスと関連する聴覚系疾患の解析 (2012)
  • Author(s): 大神信孝
  • Organizer: 第132回日本薬学会年会
  • Place of Presentation: 北海道大学・札幌キャンパス（札幌）
• [Presentation] 環境ストレスと関連する聴覚系疾患の解析 (2012)
  • Author(s): 大神信孝
  • Organizer: 第82回日本衛生学会総会 奨励賞受賞講演(招待講演)
  • Place of Presentation: 京都大学・吉田キャンパス（京都）
• [Presentation] 低周波騒音が平衡感覚に与える影響の解析 (2012)
  • Author(s): 田村青鳥
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都大学・吉田キャンパス（京都）
• [Presentation] 環境ストレスと関連する聴覚系疾患の解析 (2011)
  • Author(s): 大神信孝
  • Organizer: 第4回「タンパク質の異常凝集とその防御・修復機構に関する研究会」
  • Place of Presentation: 大阪
  • Year and Date: 2011-11-10
• [Presentation] 環境ストレスと関連する聴覚系疾患の解析 (2011)
  • Author(s): 大神信孝
  • Organizer: 第84回日本生化学会大会・シンポジウム「D-アミノ酸の生化学:飛躍する新領域」
  • Place of Presentation: 京都
  • Year and Date: 2011-09-24
• [Presentation] 新規難聴遺伝子 c-Ret の解析 (2011)
  • Author(s): 大神信孝 、田村青鳥、加藤昌志
  • Organizer: 第34回日本神経科学大会/Neuroscience2011
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-17
• [Presentation] 騒音ストレスと関連する新規聴力制御遺伝子の解析 (2011)
  • Author(s): 大神信孝 、田村青鳥、加藤昌志
  • Organizer: フォーラム 2011:衛生薬学・環境トキシコロジー
  • Place of Presentation: 金沢
• [Presentation] Endothelin receptor B in spiral ganglion neurons partially contributes topostnatal development of hearing (2011)
  • Author(s): 大神信孝 、飯田真智子、田村青鳥、加 藤昌志
  • Organizer: 第35回日本神経科学大会/Neuroscience2012
  • Place of Presentation: 名古屋
• [Presentation] Environmental stress-related diseases-Noise-induced physiological impairments- (2011)
  • Author(s): Ohgami, N.
  • Organizer: The 2nd International Symposium of Environmental Health Sciences in Malaysia
  • Place of Presentation: University Malaysia Sabah (Malaysia)
• [Presentation] Environmental stress-related diseases-Noise-induced physiological impairments- (2011)
  • Author(s): Ohgami N
  • Organizer: The 2nd International Symposium of Environmental Health Sciences in Malaysia.(招待講演)
  • Place of Presentation: University Malaysia Sabah, Malaysia
• [Presentation] 新規難聴遺伝子c-Retの解析 (2011)
  • Author(s): 大神信孝
  • Organizer: 第34回日本神経科学大会 / Neuroscience2011
  • Place of Presentation: パシフィコ横浜（横浜）
• [Presentation] 環境ストレスと関連する聴覚系疾患の解析 (2011)
  • Author(s): 大神信孝
  • Organizer: 第84回日本生化学会大会・シンポジウム(招待講演)
  • Place of Presentation: 京都国際会議場（京都）
• [Presentation] 騒音ストレスと関連する新規聴力制御遺伝子の解析 (2011)
  • Author(s): 大神信孝
  • Organizer: フォーラム2011：衛生薬学・環境トキシコロジー
  • Place of Presentation: 金沢エクセル東急（金沢）
• [Presentation] 環境ストレスと関連する聴覚系疾患の解析 (2011)
  • Author(s): 大神信孝
  • Organizer: 第4回「タンパク質の異常凝集とその防御・修復機構に関する研究会」
  • Place of Presentation: 京都大学原子炉実験所 （大阪）
• [Presentation] Environmental stress-related diseases-Noise-induced physiological impairments-.
  • Author(s): Ohgami N
  • Organizer: The 3rd International Symposium of Environmental Health Sciences in Hanoi, Vietnam
  • Place of Presentation: Hanoi University of Technology, Hanoi, Vietnam
  • Invited
• [Presentation] Analysis of molecular targets expressed in spiral ganglion neurons to prevent hearing losses.
  • Author(s): Ohgami N
  • Organizer: Department seminar at Dept. of Biochemistry, Dartmouth Medical School
  • Place of Presentation: Dartmouth Medical School, Hanover, NH, USA
  • Invited
• [Presentation] 低周波騒音が平衡感覚に与える影響
  • Author(s): 大神信孝
  • Organizer: フォーラム2012：衛生薬学・環境トキシコロジー
  • Place of Presentation: 名古屋観光ホテル (名古屋)
• [Presentation] 環境ストレスと関連する聴覚系疾患の解析
  • Author(s): 大神信孝
  • Organizer: 第5回「タンパク質の異常凝集とその防御・修復機構に関する研究会」
  • Place of Presentation: 京都大学原子炉実験所 （大阪）
• [Presentation] Analysis of endothelin receptor B expressed in spiral ganglion neurons.
  • Author(s): 大神信孝
  • Organizer: 第24回日本色素細胞学会学術大会
  • Place of Presentation: 長浜バイオ大学（長浜）
• [Presentation] 低周波騒音曝露による平衡感覚異常の解析
  • Author(s): 大神信孝
  • Organizer: 第12回分子予防環境医学研究会
  • Place of Presentation: つくばサイエンスインフォメーションセンター（筑波）
• [Remarks]
• [Patent(Industrial Property Rights)] 聴覚障害又は小脳性運動失調症の予 防・治療剤 (2012)
  • Inventor(s): 大神信孝 、加藤昌志
  • Industrial Property Rights Holder: 中部大学
  • Industrial Property Number: 2012-259456
  • Filing Date: 2012-11-28
• [Patent(Industrial Property Rights)] 聴覚障害又は小脳性運動失調症の予防・治療剤 (2012)
  • Inventor(s): 大神信孝、 加藤昌志
  • Industrial Property Rights Holder: 中部大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-11-28