Pioneering activities of novel selenium compounds polyselenodithiols leading to elucidation of selenium metabolism network
| Project/Area Number |
23790161
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental pharmacy
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| Research Institution | Meijo University |
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Principal Investigator |
UEDA Koji 名城大学, 薬学部, 助教 (30351092)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | セレン代謝 / チオール / セレノトリスルフィド / 活性酸素 / 抗がん活性 / セレン / 酸化ストレス / グルタチオン / 酸化的損傷 / 抗酸化 |
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| Research Abstract |
Selenium (Se) is remained to be elucidated in its metabolism network, through which biological effects of Se such as nutritional essentiality, toxicity, and anti-carcinogenic activity are exerted. We have investigated the basic chemical mechanisms underlying the biological effects of Se. The results indicate that thiols stimulate metabolism of Se and continuous production of oxygen radicals. Se metabolism network will be understood in the chemistry with thiols.
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Report
(3 results)
Research Products
(34 results)
