| Project/Area Number |
23790166
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental pharmacy
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| Research Institution | Matsuyama University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | シデロフォア / 鉄 / 病原ビブリオ / 腸炎ビブリオ / ビブリオ属菌 |
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| Research Abstract |
Iron is an essential element for bacterial survival, and its acquisition is crucial for the ability of most pathogenic bacteria to establish and maintain an infection within the host. Vibrio parahaemolyticus, a human pathogen causing watery diarrhea, can produce vibrioferrin, a type of siderophore which is a low-molecular-weight iron-binding chelator produced by microbes, and can acquire iron provided by iron-vibrioferrin complex. In this study, I clarified a novel regulatory system for production of vibrioferrin. Moreover, I examined a physiological function of vibrioferrin against host cells, and also assessed the influence of the deletion of gene involved in vibrioferrin production on cytotoxicity of V. parahaemolyticus.
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