Characterization of kidney specific organic anion transporter SLCO4C1

• Project/Area Number: 23790168
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Hokkaido University
• Principal Investigator: YAMAGUCHI Hiroaki 北海道大学, 大学院・薬学研究院, 准教授 (80400373)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 薬物動態・代謝学 / 異物排泄 / トランスポーター / 腎臓

Research Abstract

Novel substrates for SLCO4C1 were searched and the contribution of SLCO4C1 to the renal uptake of the substrates in renal proximal tubular epithelial cells HK-2 cells was examined. As results, quinolinic acid and indole-3-acetate were found as novel substrates for SLCO4C1. SLCO4C1 mainly contributes to renal uptake of digoxin and ouabain in HK-2 cells.

Research Products

• [Journal Article] Quantification of intact carboplatin in human plasma ultrafitrates using hydrophilic interaction liquid chromatography–tandem mass spectrometry and its application to a pharmacokinetic study (2013)
  • Author(s): Hajime Ito, Hiroaki Yamaguchi, Asuka Fujikawa, Narumi Shiida, Nobuaki Tanaka, Jiro Ogura, Masaki Kobayashi, Takehiro Yamada, Nariyasu Mano, Ken Iseki
  • Journal Title: Journal of Chromatography B Volume: 917-918 Pages: 18-23
  • DOI: 10.1016/j.jchromb.2012.11.024
  • Peer Reviewed
• [Journal Article] Renal Uptake of Substrates for Organic Anion Transporters Oat1 and Oat3 and Organic Cation Transporters Oct1 and Oct2 is Altered in Rats with Adenine-Induced Chronic Renal Failure (2013)
  • Author(s): 駒澤宏紀、山口浩明ら、他4名
  • Journal Title: Journal of Pharmaceutical Sciences Volume: 102巻 Issue: 3 Pages: 1086-1094
  • DOI: 10.1002/jps.23433
  • Peer Reviewed
• [Journal Article] Quantitative determination of paclitaxel and its metabolites, 6a-hydroxypaclitaxel and p-3’-hydroxypaclitaxel, in human plasma using column-switching liquid chromatography/tandem mass spectrometry (2013)
  • Author(s): Hiroaki Yamaguchi, Asuka Fujikawa, Hajime Ito, Nobuaki Tanaka, Ayako Furugen, Kazuaki Miyamori, Natsuko Takahashi, Jiro Ogura, Masaki Kobayashi, Takehiro Yamada, Nariyasu Mano, Ken Iseki
  • Journal Title: Biomedical Chromatography Volume: 27 Issue: 4 Pages: 539-544
  • DOI: 10.1002/bmc.2826
  • Peer Reviewed
• [Journal Article] Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry (2012)
  • Author(s): Saigusa D, Shiba K, Inoue A, Hama K, Okutani M, Iida N, Saito M, Suzuki K, Kaneko T, Suzuki N, Yamaguchi H, Mano N, Goto J, Hishinuma T, Aoki J, Tomioka Y
  • Journal Title: Anal Bioanal Chem Volume: 403巻 Issue: 7 Pages: 1897-1905
  • DOI: 10.1007/s00216-012-6004-9
  • Peer Reviewed
• [Journal Article] スタチンの骨格筋障害に及ぼす酸・アルカリ化誘導剤の影響 (2012)
  • Author(s): 小林正紀、日高和宏、山口浩明ら、他6名
  • Journal Title: YAKUGAKU ZASSHI Volume: 132巻 Pages: 609-615
  • NAID: 130001888677
  • URL: https://www.jstage.jst.go.jp/article/yakushi/132/5/132_5_609/_pdf
  • Peer Reviewed
• [Journal Article] The Decrease in Farnesoid X Receptor, Pregnane X Receptor and Constitutive Androstane Receptor in the Liver after Intestinal Ischemia-Reperfusion (2012)
  • Author(s): 小倉次郎、寺田悠介、山口浩明ら、他11名
  • Journal Title: Journal of Pharmacy& Pharmaceutical Sciences Volume: 15巻 Pages: 616-631
  • URL: http://ejournals.library.ualberta.ca/index.php/JPPS/issue/view/1388
  • Peer Reviewed
• [Journal Article] Intestinal Ischemia-Reperfusion Increases Efflux for Uric Acid Via Paracellular Route in the Intestine, but Decreases that Via Transcellular Route Mediated by BCRP (2012)
  • Author(s): 小倉次郎、桑山果織、山口浩明ら、他11名
  • Journal Title: Journal of Pharmacy & Pharmaceutical Sciences Volume: 15巻 Pages: 295-304
  • URL: http://ejournals.library.ualberta.ca/index.php/JPPS/issue/view/1237
  • Peer Reviewed
• [Journal Article] A full validated hydrophilic interaction liquid chromatography-tandem mass spectrometric method for the quantification of oxaliplatin in human plasma ultrafiltrates (2012)
  • Author(s): 伊藤創、山口浩明ら、他10名
  • Journal Title: Journal of Pharmaceutical and Biomedical Analysis Volume: 71巻 Pages: 99-103
  • DOI: 10.1016/j.jpba.2012.08.010
  • NAID: 120004857025
  • Peer Reviewed
• [Journal Article] A rapid and sensitive LC/ESI-MS/MS method for quantitative analysis of docetaxel in human plasma and its application to a pharmacokinetic study (2012)
  • Author(s): 山口浩明ら、他11名
  • Journal Title: Chromatography B Volume: 893-894巻 Pages: 157-161
  • DOI: 10.1016/j.jchromb.2012.02.003
  • NAID: 120004856992
  • Peer Reviewed
• [Journal Article] Regulation of human monocarboxylate transporter 4 in skeletal muscle cells: The role of protein kinase C (PKC) (2012)
  • Author(s): 鳴海克哉、小林正紀、山口浩明ら、他8名
  • Journal Title: International Journal of Pharmaceutics Volume: 428巻 Issue: 1-2 Pages: 25-32
  • DOI: 10.1016/j.ijpharm.2012.02.021
  • Peer Reviewed
• [Journal Article] Intestinal Ischemia-Reperfusion Increases Efflux for Uric Acid Via Paracellular Route in the Intestine, but Decreases that Via Transcellular Route Mediated by BCRP (2012)
  • Author(s): Jiro Ogura, Kaori Kuwayama, Atsushi Takaya et al.
  • Journal Title: Journal of Pharmacy & Pharmaceutical Sciences Volume: 15 Pages: 295-304
  • Peer Reviewed
• [Journal Article] The Decrease in Farnesoid X Receptor, Pregnane X Receptor and Constitutive Androstane Receptor in the Liver after Intestinal Ischemia-Reperfusion (2012)
  • Author(s): Jiro Ogura, Yusuke Terada, Takashi Tsujimoto et al.
  • Journal Title: Journal of Pharmacy & Pharmaceutical Sciences Volume: 15 Pages: 616-631
  • Peer Reviewed
• [Journal Article] スタチンの骨格筋障害に及ぼす酸・アルカリ化誘導剤の影響 (2012)
  • Author(s): 小林正紀、日高和宏、知嵜郁美、高橋夏子、小倉次郎、板垣史郎、平野剛、山口浩明、井関健
  • Journal Title: YAKUGAKU ZASSHI Volume: 132 Pages: 609-615
  • NAID: 130001888677
  • Peer Reviewed
• [Journal Article] Quantitation of five prostanoids in both cultured cells and media by liquid chromatography/electrosprav ionization tandem mass spectrometry (2011)
  • Author(s): Ayako Furugen
  • Journal Title: Journal of Chromatography B Volume: 879 Issue: 30 Pages: 3378-3385
  • DOI: 10.1016/j.jchromb.2011.09.003
  • Peer Reviewed
• [Presentation] Contribution of multidrug resistance-associated proteins (MRP) tothe release of prostanoids from human lung adenocarcinoma epithelial A549 cells (2012)
  • Author(s): 古堅彩子、山口浩明、田中伸明、椎田成美、井関健
  • Organizer: 日本薬物動態学会第27回年会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2012-11-20
• [Presentation] SLCO1B3-specific compound LST-02 (2012)
  • Author(s): 阿部高明、山口浩明、後藤順一、眞野成康
  • Organizer: 日本薬 物動態学会第27回年会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2012-11-20
• [Presentation] DCF療法における各抗がん薬血中濃度の解析 (2012)
  • Author(s): 山口浩明
  • Organizer: 第46回医療薬学公開シンポジウム
  • Place of Presentation: にぎわい交流館(秋田県)(招待講演)
  • Year and Date: 2012-07-28
• [Presentation] SLCO1B3-specific compound LST-02 (2012)
  • Author(s): 阿部高明
  • Organizer: 日本薬物動態学会 第27回年会
  • Place of Presentation: タワーホール船堀（東京都）
• [Presentation] Contribution of multidrug resistance-associated proteins (MRP) to the release of prostanoids from human lung adenocarcinoma epithelial A549 cells (2012)
  • Author(s): 古堅彩子
  • Organizer: 日本薬物動態学会 第27回年会
  • Place of Presentation: タワーホール船堀（東京都）
• [Presentation] Statins regulate multidrug resistance-associated protein 2 (MRP2, ABCC2) expression and function: involvement of SREBP-1 mediated gene regulation (2011)
  • Author(s): 小林正紀、合田圭祐、知嵜郁美、山口浩明、井関健
  • Organizer: 日本薬物動態学会第26年会
  • Place of Presentation: 広島国際会議場(広島県)
  • Year and Date: 2011-11-16
• [Presentation] The decrease in bcrp transport activity after intestinal ischemiareperfusion (2011)
  • Author(s): 小倉次郎、桑山果織、高谷厚、寺田悠介、辻本高志、小泉貴寛、山口浩明、井関健
  • Organizer: 日本薬物動態学会第26年会
  • Place of Presentation: 広島国際会議場(広島県)
  • Year and Date: 2011-11-16
• [Presentation] LC/MS/MS analysis of extracellular and intracellular prsostanoids in cultured cells: evaluation of functionalimportance of mrp4 in prostanoid release (2011)
  • Author(s): 古堅彩子、山口浩明、井関健
  • Organizer: 日本薬物動態学会第26年会
  • Place of Presentation: 広島国際会議場(広島県)
  • Year and Date: 2011-11-16
• [Presentation] 抗悪性腫瘍薬オキサリプラチンのHILIC/MS/MSによる血中濃度測定法の確立 (2011)
  • Author(s): 伊藤創、山口浩明、藤川あす歌、山田武宏、眞野成康、井関健
  • Organizer: 第22回クロマトグラフィー科学会議
  • Place of Presentation: 東北大学(仙台市)
  • Year and Date: 2011-10-22
• [Presentation] LC/ESI-MS/MSによる血中ドセタキセルの簡易定量法の構築とその臨床応用 (2011)
  • Author(s): 山口浩明、藤川あす歌、伊藤創、田中伸明、山田武宏、眞野成康、井関健
  • Organizer: 第22回クロマトグラフィー科学会議
  • Place of Presentation: 東北大学(仙台市)
  • Year and Date: 2011-10-22
• [Presentation] 臨床検査値の変動から推測されるスタチン系薬物由来の副作用発生率の解析研究 (2011)
  • Author(s): 落合愛美、小林正紀、川岸亨、笠師久美子、山口浩明、山田武宏、井関健
  • Organizer: 第21回日本医療薬学会年会
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2011-10-01
• [Presentation] PKCを介した糖代謝制御およびMCT4発現変動への関連性 (2011)
  • Author(s): 大竹翔、鳴海克哉、小林正紀、山口浩明、井関健
  • Organizer: 第21回日本医療薬学会年会
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2011-10-01
• [Presentation] LC/MS/MS ANALYSIS OF EXTRACELLULAR AND INTRACELLULAR PRSOSTANOIDS IN CULTURED CELLS: EVALUATION OF FUNCTIONAL IMPORTANCE OF MRP4 IN PROSTANOID RELEASE (2011)
  • Author(s): 古堅 彩子、山口 浩明、井関 健
  • Organizer: 日本薬物動態学会第26年会
  • Place of Presentation: 広島国際会議場（広島県）
• [Presentation] THE DECREASE IN BCRP TRANSPORT ACTIVITY AFTER INTESTINAL ISCHEMIA-REPERFUSION (2011)
  • Author(s): 小倉 次郎、桑山 果織、高谷 厚、寺田 悠介、辻本 高志、小泉 貴寛、山口 浩明、井関 健
  • Organizer: 日本薬物動態学会第26年会
  • Place of Presentation: 広島国際会議場（広島県）
• [Presentation] Statins regulate multidrug resistance-associated protein 2 (MRP2, ABCC2) expression and function: involvement of SREBP-1 mediated gene regulation (2011)
  • Author(s): 小林 正紀、合田 圭祐、知嵜 郁美、山口 浩明、井関 健
  • Organizer: 日本薬物動態学会第26年会
  • Place of Presentation: 広島国際会議場（広島県）
• [Presentation] LC/ESI-MS/MS による血中ドセタキセルの簡易定量法の構築とその臨床応用 (2011)
  • Author(s): 山口 浩明、藤川 あす歌、伊藤 創、田中 伸明、山田 武宏、眞野 成康、井関 健
  • Organizer: 第22回クロマトグラフィー科学会議
  • Place of Presentation: 東北大学（仙台市）
• [Presentation] 抗悪性腫瘍薬オキサリプラチンのHILIC/MS/MSによる血中濃度測定法の確立 (2011)
  • Author(s): 伊藤 創、山口 浩明、藤川 あす歌、山田 武宏、眞野 成康、井関 健
  • Organizer: 第22回クロマトグラフィー科学会議
  • Place of Presentation: 東北大学（仙台市）
• [Presentation] PKCを介した糖代謝制御およびMCT4発現変動への関連性 (2011)
  • Author(s): 大竹 翔、鳴海 克哉、小林 正紀、山口 浩明、 井関 健
  • Organizer: 第21回日本医療薬学会年会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] 臨床検査値の変動から推測されるスタチン系薬物由来の副作用発生率の解析研究 (2011)
  • Author(s): 落合愛美、小林正紀、川岸亨、笠師久美子、山口浩明、山田武宏、井関 健
  • Organizer: 第21回日本医療薬学会年会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] DCF療法における各抗がん薬血中濃度の解析
  • Author(s): 山口浩明
  • Organizer: 第４６回医療薬学公開シンポジウム
  • Place of Presentation: にぎわい交流館（秋田県）
  • Invited
• [Remarks] 北海道大学大学院薬学研究院・生命科学院臨床薬剤学研究室
  • URL: http://rinyaku.pharm.hokudai.ac.jp/
• [Remarks] 北海道大学大学院薬学研究院・生命科学院 臨床薬剤学研究室
  • URL: http://rinyaku.pharm.hokudai.ac.jp/