Characterization of kidney specific organic anion transporter SLCO4C1
| Project/Area Number |
23790168
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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|---|
| Keywords | 薬物動態・代謝学 / 異物排泄 / トランスポーター / 腎臓 |
|---|
| Research Abstract |
Novel substrates for SLCO4C1 were searched and the contribution of SLCO4C1 to the renal uptake of the substrates in renal proximal tubular epithelial cells HK-2 cells was examined. As results, quinolinic acid and indole-3-acetate were found as novel substrates for SLCO4C1. SLCO4C1 mainly contributes to renal uptake of digoxin and ouabain in HK-2 cells.
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Report
(3 results)
Research Products
(36 results)
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Journal Title
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Volume: 27
Issue: 4
Pages: 539-544
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Journal Title
Anal Bioanal Chem
Volume: 403巻
Issue: 7
Pages: 1897-1905
DOI
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Peer Reviewed
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