Clinical implication of individual variation of drug transporter (OATP2B1) activity.

• Project/Area Number: 23790184
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Tottori University
• Principal Investigator: TAKANE Hiroshi 鳥取大学, 医学部附属病院, 准教授 (50444641)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 遺伝子 / 薬剤反応性 / 循環器・高血圧

Research Abstract

We examined the contribution of genetic variants in the SLCO2B1 gene to the variability of celiprolol efficacy in hypertensive patients. The patients homozygous for SLCO2B1*3 result in decreased plasma concentration of celiprolol, resulting in decrease of its hypotensive effect. Further study is necessary to confirm the influence of genetic variants in the gene on the hypotensive efficacy of celiprolol in a large sample size