| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
In this study, we sought to determine molecular mechanisms responsible for post-translational regulation of BCRP and ABCG5/8, disease-associated ABC transporter family proteins. Here, we showed that Derlin-1 is a negative regulator for both glycosylated and non-glycosylated BCRP expression. Moreover, we demonstrated HRD1 as a regulator of post-translational N-glycosylation of ABCG8 that affects protein stability. Overall, we clearly indicate the molecular basis of Derlin-1- and HRD1-dependent negative regulation of BCRP and ABCG5/ABCG8.
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