Post-translational Regulation of Disease-associated ABC Transporters by Derlin1 and HRD1
| Project/Area Number |
23790188
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
SHUTO Tsuyoshi 熊本大学, 大学院・生命科学研究部, 講師 (80333524)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ABC トランスポーター / 翻訳後調節 / ABCG5/8 / BCRP / N 型糖鎖 / ABCトランスポーター / 翻訳後修飾 / N型糖鎖 / HRD1 / RMA1 / 翻訳後発現調節 / 小胞体関連分解 |
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| Research Abstract |
In this study, we sought to determine molecular mechanisms responsible for post-translational regulation of BCRP and ABCG5/8, disease-associated ABC transporter family proteins. Here, we showed that Derlin-1 is a negative regulator for both glycosylated and non-glycosylated BCRP expression. Moreover, we demonstrated HRD1 as a regulator of post-translational N-glycosylation of ABCG8 that affects protein stability. Overall, we clearly indicate the molecular basis of Derlin-1- and HRD1-dependent negative regulation of BCRP and ABCG5/ABCG8.
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Report
(3 results)
Research Products
(47 results)
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[Journal Article] Diethyldithiocarbamate induces apoptosis in HHV-8-infected primary effusion lymphoma cells via inhibition of the NF-κB pathway.2012
Author(s)
Matsuno T, Kariya R, Yano S, Morino-Koga S, Taura M, Suico MA, Shimauchi Y, Matsuyama S, Okamoto Y, Shuto T, Kai H, Okada S.
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Journal Title
Int J Oncol
Volume: 40(4)
Pages: 1071-1078
Related Report
Peer Reviewed
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[Journal Article] Rb/E2F1 Regulates the Innate Immune Receptor Toll-Like Receptor 3 in Epithelial Cells.2012
Author(s)
Taura M, Suico MA, Koyama K, Komatsu K, Miyakita R, Matsumoto C, Kudo E, Kariya R, Goto H, Kitajima S, Takahashi C, Shuto T, Nakao M, Okada S, Kai H.
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Journal Title
Mol Cell Biol.
Volume: 32(8)
Pages: 1581-1590
Related Report
Peer Reviewed
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[Journal Article] Posttranslational negative regulation ofglycosylated and non-glycosylated BCRPexpression by Derlin-12011
Author(s)
Sugiyama, T., T. Shuto, S. Suzuki, T.Sato, T. Koga, M.A. Suico, H. Kusuhara, Y.Sugiyama, D.M. Cyr, and H. Kai
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Journal Title
Biochem Biophys Res Commun
Volume: 404
Issue: 3
Pages: 853-858
DOI
Related Report
Peer Reviewed
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[Journal Article] Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNFα induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK.2011
Author(s)
Watanabe K, Shuto T, Sato M, Onuki K, Mizunoe S, Suzuki S, Sato T, Koga T, Suico MA, Kai H, Ikeda T.
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Journal Title
Biochem Biophys Res Commun
Volume: 408(1)
Pages: 18-24
Related Report
Peer Reviewed
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[Journal Article] CFTR-deficiency renders mice highly susceptible to cutaneous symptoms during mite infestation.2011
Author(s)
Hashimoto Y, Shuto T, Mizunoe S, Tomita A, Koga T, Sato T, Takeya M, Suico MA, Niibori A, Sugahara T, Shimasaki S, Sugiyama T, Scholte B, Kai H.
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Journal Title
Lab Invest
Volume: 91(4)
Pages: 509-518
Related Report
Peer Reviewed
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