Exploration of the drug for atherosclerosis which related to the proliferation of smooth muscle cells-induced rupture of vascular redox homeostasis
| Project/Area Number |
23790190
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | Gifu Pharmaceutical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | EC-SOD / MEK/ERK / フラボノイド / FCS / Flavonoid |
|---|
| Research Abstract |
We investigated the regulation of EC-SOD during FCS-induced VSMCs proliferation to explore the drug for atherosclerosis. We confirmed that the reduction of EC-SOD during FCS-induced cells proliferation through MEK/ERK-derived signaling. Further, pretreatment with flavonoids such as luteolin and chrysoeriol significantly suppressed FCS-triggered EC-SOD reduction. Overall, we suggested that the regulation of EC-SOD might lead to improve vascular diseases.
|
Report
(3 results)
Research Products
(30 results)
