Basic research for development of new drugs based on the regulationof ABC transporters activity and expression
| Project/Area Number |
23790196
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 薬物動態 / 代謝学 / ABC 輸送体 / P-糖タンパク質 / ユビキチン化 / FBXO15 / Ube2r1 / PP5 / PPP2R3C |
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| Research Abstract |
P-glycoprotein (P-gp) is a member of the ABC transporters and transports several anticancer drugs. Overexpression of P-gp in cancer cells contributes resistance to the anticancer agents. This study aimed to clarify the mechanisms o
(1) P-gp wasrecognized by SCFFBX15, ubiquitinated by Ube2r1/Cdc34/Ubc3 and then degraded by the proteasome;
(2) expression of the protein dephosphorylation complex PP5/PPP2R3Clowered P-gp expression.
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Report
(3 results)
Research Products
(32 results)
