Molecular basis of mechanisms underlying transplacental drugtransfer in corporation with placental endocrine function

• Project/Area Number: 23790199
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Keio University
• Principal Investigator: TOMI Masatoshi 慶應義塾大学, 薬学部, 准教授 (30334717)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 胎盤関門 / 内分泌 / トランスポーター

Research Abstract

Organic anion transporter (OAT) 4 expressed at the basolateral membrane of the placental barrier appears to play a principal role in the uptake of 16α-OH DHEAS and contribute to the E3 synthesis during pregnancy. Moreover, the expression of OAT4

Research Products

• [Journal Article] Estrogen receptor α induction by mitoxantrone increases Abcg2 expression in placental trophoblast cells. (2013)
  • Author(s): Oda K, Nishimura T, Higuchi K, Ishido N, Ochi K, Iizasa H, Sai Y, Tomi M, Nakashima E.
  • Journal Title: J Pharm Sci Volume: 102 Issue: 9 Pages: 3364-3372
  • DOI: 10.1002/jps.23549
  • Peer Reviewed
• [Journal Article] Mechanism of Nucleoside Uptake in Rat Placenta and Induction of Placental CNT2 in Experimental Diabetes (2012)
  • Author(s): Nishimura T, Chishu T, Tomi M, Nakamura R, Sato K, Kose N, Sai Y, Nakashima E
  • Journal Title: Drug Metabolism and Pharmacokinetics Volume: 27 Issue: 4 Pages: 439-446
  • DOI: 10.2133/dmpk.DMPK-11-RG-103
  • NAID: 130004463266
  • ISSN: 1347-4367, 1880-0920
  • Peer Reviewed
• [Journal Article] Strategies for therapy of retinal diseases using systemic drug delivery: relevance of transporters at the blood-retinal barrier (2011)
  • Author(s): Hosoya K, Tomi M, Tachikawa M
  • Journal Title: Expert Opin Drug Deliv Volume: 8(12) Issue: 12 Pages: 1571-1587
  • DOI: 10.1517/17425247.2011.628983
  • Peer Reviewed
• [Journal Article] Mother-to-fetus transfer of antiviral drugs and the involvement of transporters at the placental barrier (2011)
  • Author(s): Tomi M, Nishimura T, Nakashima E.
  • Journal Title: J Pharm Sci Volume: 100 Issue: 9 Pages: 3708-3718
  • DOI: 10.1002/jps.22642
  • Peer Reviewed
• [Journal Article] Enhancement of zidovudine transfer to molt-4 cells, a human t-cell model, by dehydroepiandrosterone sulfate (2011)
  • Author(s): Nishimura T, Tanaka J, Tomi M, Seki Y, Kose N, Sai Y, Nakashima E.
  • Journal Title: J Pharm Sci Volume: 100 Issue: 9 Pages: 3959-3967
  • DOI: 10.1002/jps.22624
  • Peer Reviewed
• [Presentation] 医薬品の胎盤透過制御機構とその in vitro 評価 (2012)
  • Author(s): 登美斉俊、西村友宏、中島恵美
  • Organizer: 日本動物実験代替法学会第25回大会
  • Place of Presentation: 東京
  • Year and Date: 2012-12-08
• [Presentation] Role of anion transporters, IN:Workshop 11 "The role of human placenta in regulating fetal exposure to medications during pregnancy (2012)
  • Author(s): Tomi M
  • Organizer: IFPA Meeting 2013
  • Place of Presentation: 広島
  • Year and Date: 2012-09-21
• [Presentation] Role of organic anion transporter (OAT) 4 on estriol synthesis in the placental syncytiotrophoblasts. (2012)
  • Author(s): Tomi M, Ozaki M, Nishimura S, Higuchi K, Nishimura T, Nakashima E
  • Organizer: IFPA Meeting 2013
  • Place of Presentation: 広島
  • Year and Date: 2012-09-18
• [Presentation] 胎盤エストロゲン合成におけるorganic anion transporter (OAT) 4 の役割 (2012)
  • Author(s): 西村祥香,西村友宏,樋口慧,登美斉俊,中島恵美 .
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-31
• [Presentation] Role of OAT4 for supplying estriol precursor, 16α-hydroxy dehydroepiandrosterone sulfate, into the human placenta (2012)
  • Author(s): Tomi M, Ozaki M, Nishimura S, Higuchi K, Nishimura T, Nakashima E
  • Organizer: International Symposium on Past, Present and Future of Molecular Pharmacokinetics
  • Place of Presentation: 東京
  • Year and Date: 2012-01-17
• [Presentation] Role of anion transporters, IN:Workshop 11 “The role of human placenta in regulating fetal exposure to medications during pregnancy. (2012)
  • Author(s): 登美斉俊
  • Organizer: IFPA Meeting 2012
  • Place of Presentation: 広島国際会議場（広島市）
  • Invited
• [Presentation] 医薬品の胎盤透過制御機構とそのin vitro評価 (2012)
  • Author(s): 登美斉俊、西村友宏、中島恵美
  • Organizer: 日本動物実験代替法学会第25回大会
  • Place of Presentation: 慶應義塾大学（東京都）
• [Presentation] Role of organic anion transporter (OAT) 4 on estriol synthesis in the placental syncytiotrophoblasts. (2012)
  • Author(s): Tomi M, Ozaki M, Nishimura S, Higuchi K, Nishimura T, Nakashima E.
  • Organizer: IFPA Meeting 2012
  • Place of Presentation: 広島国際会議場（広島市）
• [Presentation] Role of OAT4 for supplying estriol precursor, 16α-hydroxy dehydroepiandrosterone sulfate, into the human placenta. (2012)
  • Author(s): Tomi M, Ozaki M, Nishimura S, Higuchi K, Nishimura T, Nakashima E.
  • Organizer: International Symposium on Past, Present and Future of Molecular Pharmacokinetics
  • Place of Presentation: 一橋記念講堂（東京都）
• [Presentation] 胎盤エストロゲン合成におけるorganic anion transporter (OAT) 4 の役割. (2012)
  • Author(s): 西村祥香,西村友宏,樋口慧,登美斉俊,中島恵美.
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学（北海道札幌市）
• [Presentation] OAT4/SLC22A11-mediated uptake of 16α-hydroxydehydroepiandro- sterone sulfate at the placental barrier (2011)
  • Author(s): Tomi M, Ozaki M, Higuchi K, Nishimura T, Nakashima E
  • Organizer: Asian Federation for Pharmaceutical Sciences 2011
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 2011-12-11
• [Presentation] 胎盤関門における OAT4 の生理的役割とその発現制御 (2011)
  • Author(s): 登美斉俊、尾崎真由子、宮田優希、西村祥香、樋口慧、西村友宏、中島恵美
  • Organizer: 第33回生体膜と薬物の相互作用シンポジウ
  • Place of Presentation: 岡山
  • Year and Date: 2011-11-25
• [Presentation] OAT4 を介したエストリオール前駆体16α-OH DHEAS 輸送機構とその役割 (2011)
  • Author(s): 登美斉俊, 尾崎真由子, 西村友宏, 中島恵美
  • Organizer: 第6回トランスポーター研究会年
  • Place of Presentation: 仙台
  • Year and Date: 2011-06-11
• [Presentation] 胎盤関門 OAT4 を介したエストリオール前駆体 16α-OH DHEAS 輸送機構 (2011)
  • Author(s): 登美斉俊, 尾崎真由子, 西村友宏, 中島恵美
  • Organizer: 日本薬剤学会第26年会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-31
• [Presentation] OAT4/SLC22A11-mediated uptake of 16α-hydroxydehydroepiandrosterone sulfate at the placental barrier. (2011)
  • Author(s): Tomi M, Ozaki M, Higuchi K, Nishimura T, Nakashima E.
  • Organizer: Asian Federation for Pharmaceutical Sciences 2011
  • Place of Presentation: Renaissance Hotel Kuala Lumpur (Kuala Lumpur, Malaysia)
• [Presentation] 胎盤関門OAT4を介したエストリオール前駆体16α-OH DHEAS輸送機構. (2011)
  • Author(s): 登美斉俊, 尾崎真由子, 西村友宏, 中島恵美.
  • Organizer: 日本薬剤学会第26年会
  • Place of Presentation: タワーホール船堀（東京都）
• [Presentation] OAT4を介したエストリオール前駆体16α-OH DHEAS輸送機構とその役割. (2011)
  • Author(s): 登美斉俊, 尾崎真由子, 西村友宏, 中島恵美.
  • Organizer: 第6回トランスポーター研究会年会
  • Place of Presentation: 東北大学（宮城県仙台市）
• [Presentation] 胎盤関門におけるOAT4の生理的役割とその発現制御. (2011)
  • Author(s): 登美斉俊、尾崎真由子、宮田優希、西村祥香、樋口慧、西村友宏、中島恵美.
  • Organizer: 第33回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 岡山大学（岡山県岡山市）