| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
We investigated the effect of chitosan on oxidative stress and related biochemical properties in lifestyle diseases. In metabolic syndrome patients or model rats, chitosan has a high antioxidant activity as well as the ability to exert antilipidemic effects. Furthermore, in chronic renal failure (CRF) patients or model rats, chitosan has a high antioxidant activity as well as the ability to exert reno-protective effects. From these results, we hypothesize that chitosan reduces the levels of lipids and/or uremic toxins that induce the production of reactive oxygen species in the intestinal tract, thereby inhibiting the subsequent development of oxidative stress in the systemic circulation in the metabolic syndrome or CRF. Thus, the pleiotropic effects of chitosan might lead to the development of effective new methods for the treatment of such diseases and for reducing oxidative stress associated with lifestyle diseases such as metabolic syndrome or CRF.
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