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Search for metastasis-related proteins in colorectal cancer by proteome analysis

Research Project

Project/Area Number 23790216
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research Institution独立行政法人医薬基盤研究所

Principal Investigator

NAGANO Kazuya  独立行政法人医薬基盤研究所, 創薬基盤研究部, 研究員 (40548301)

Co-Investigator(Renkei-kenkyūsha) TSUNODA Shin-ichi  (独)医薬基盤研究所, バイオ創薬プロジェクト, プロジェクトリーダー (90357533)
KAMADA Haruhiko  (独)医薬基盤研究所, バイオ創薬プロジェクト, サブプロジェクトリーダー (00324509)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords医療薬剤学 / プロテオミクス / 癌 / 蛋白質 / 生体分子 / 薬学 / バイオマーカー / 転移
Research Abstract

Since metastasis is one of the most important prognostic factors in colorectal cancer, development of novel diagnostic and preventive methods for metastasis is highly desirable. However, the molecular mechanism of the metastatic phenotype has not been well elucidated. In this regard, we searched for metastasis-related proteins in colorectal cancer by analyzing the differential expression of proteins between primary and metastasis focus-derived colorectal tumor cells using a proteomics-based study. In order to validate these candidate proteins, we analyzed the expression profile of these proteins in tissue microarray. As a result, Rho GDP-dissociation inhibitor (Rho GDI) was identified as a metastasis-related protein in colon cancer patients. Consequently, Rho GDI may be useful for a diagnostic or preventive target against colon cancer metastasis.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (6 results)

  • [Journal Article] Rho GDP-dissociation inhibitor alpha is associated with cancer metastasis in colon and prostate cancer2012

    • Author(s)
      Yamashita T., Okamura T., Nagano K., Imai S., Abe Y., Nabeshi H., Yoshikawa T., Yoshioka Y., Kamada H., Tsutsumi Y., Tsunoda S
    • Journal Title

      Pharmazie

      Volume: 67(3) Pages: 253-255

    • Related Report
      2012 Final Research Report
  • [Journal Article] Rho GDP-dissociation inhibitor alpha is associated with cancer metastasis in colon and prostate cancer.2012

    • Author(s)
      Takuya Yamashita
    • Journal Title

      Pharmazie

      Volume: 67 Pages: 253-255

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Expression of Rho GDP dissociation inhibitor correlates positively with lymph node metastasis in colorectal cancer2012

    • Author(s)
      Nagano K., Okamura T., Yamashita T., Kanasaki S., Maeda Y., Inoue M., Abe Y., Kamada H., Tsutsumi Y., Tsunoda S
    • Organizer
      EACR-22
    • Place of Presentation
      Barcelona (Spain)
    • Related Report
      2012 Final Research Report
  • [Presentation] 大腸がん転移診断・治療法の開発を目指した転移関連たんぱく質の探索2012

    • Author(s)
      長野一也, 岡村賢孝, 山下琢矢, 金崎聡一郎, 前田祐香, 古屋 剛, 井上雅己, 鍋師裕美, 吉川友章, 吉岡靖雄, 阿部康弘, 鎌田春彦, 堤 康央, 角田慎一
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌(北海道)
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] Expression of Rho GDP dissociation inhibitor correlates positively with lymph node metastasis in colorectal cancer.2012

    • Author(s)
      Kazuya Nagano
    • Organizer
      EACR-22
    • Place of Presentation
      Barcelona (Spain)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Proteomic profiling of proteins associated with metastasis in colorectal cancer cell lines2011

    • Author(s)
      Yamashita T., Nagano K., Yoshikawa T., Yoshioka Y., Itoh N., Abe Y., Kamada H., Tsutsumi Y., Tsunoda S
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋(愛知)
    • Related Report
      2012 Final Research Report
  • [Presentation] プロテオミクスによる大腸がん転移関連たんぱく質の探索2011

    • Author(s)
      長野一也, 岡村賢孝, 山下琢矢, 堤 康央, 角田慎一
    • Organizer
      第20回日本がん転移学会学術集会・総会
    • Place of Presentation
      浜松(静岡)
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] Proteomic profiling of proteins associated with metastasis in colorectal cancer cell lines.2011

    • Author(s)
      Yamashita T., Nagano K., Yoshikawa T., Yoshioka Y., Itoh N., Abe Y., Kamada H., Tsutsumi Y., Tsunoda S.
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋(愛知)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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