Regulation of alternative splicing during neural development
| Project/Area Number |
23790218
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Oita University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 神経発生 / RNA splicing / 発生工学 / 神経幹細胞 / RNAスプライシング / NMD / 脳・神経 |
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| Research Abstract |
The functional coupling roles of alternative splicing and nonsense mediated mRNA decay in the developing brain had remained unclear. Therefore we generated conditional KO mouse of splicing regulatory factor PTB. We found that a loss of PTB caused serious hydrocephalus. PTB was expressed in neural stem cells and required for the maintenance of the adhesion structure of Radial glia formed in the ventricular zone, and the undifferentiated state.Furthermore, we generated UPF1 conditional KO mouse and found that UPF1 is essential for cell proliferation and neuronal differentiation.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Botch Promotes Neurogenesis by Antagonizing Notch.2012
Author(s)
Chi Z, Zhang J, Tokunaga A, Harraz MM, Byrne ST, Dolinko A, Xu J, Blackshaw S, Gaiano N, Dawson TM, Dawson VL.
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Journal Title
Dev Cell.
Volume: 22(4)
Issue: 4
Pages: 707-720
DOI
Related Report
Peer Reviewed
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