Research of dynamic differentiation and morphogenesis in 3-D epithelial tubulogenesis
Project/Area Number |
23790221
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General anatomy (including Histology/Embryology)
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Research Institution | Kanazawa University |
Principal Investigator |
SAKAI Katsuya 金沢大学, がん進展制御研究所, 助教 (10523318)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Keywords | 浸潤 / 再生医学 / 組織幹細胞 / がん化 / Tetraploid / 分化 / 形態形成 |
Research Abstract |
We aimed to elucidate molecular mechanisms of epithelial cell invasiveness and differentiation underlying epithelial cell morphogenesis. Our results are as follows. 1) Mammary epithelial cell replication is not influenced by polyploidy. 2) Activation of MMP-2 by MT1-MMP is required for 3-D invasiveness. Cell surface localization of MT1-MMP was depend on 3-D. MMP-2 expression was strongly correlated to invasiveness and regulated by epigenetics. We identified epigenetic factors and these target genes possibly involved in cancer malignancy. 3) Cell surface Met was heterogeneously expressed in mammary epithelial cells and malignant melanomas. This might reflect invasive and malignant cell phenotypes.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Pleural mesothelioma instigates tumor associated fibroblasts to promote prog-ression via malignant cytokine network2011
Author(s)
Li Q, Wang W, Yamada T, Matsumoto K, Bando Y, Uehara H, Nishioka Y, Sone S, Iwakiri S, Itoi K, Utsugi T, Yano S.
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Journal Title
Am J Pathol
Volume: 179
Issue: 3
Pages: 1483-93
DOI
Related Report
Peer Reviewed
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[Book] InTech2011
Author(s)
Sakai K, Nakamura T, Suzuki Y, Matsumoto K
Publisher
Significance, Mechanisms, and Progress of Anticancer Drugs Targeting HGF-Met
URL
Related Report
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