Research Project
Grant-in-Aid for Young Scientists (B)
We aimed to elucidate molecular mechanisms of epithelial cell invasiveness and differentiation underlying epithelial cell morphogenesis. Our results are as follows.1) Mammary epithelial cell replication is not influenced by polyploidy.2) Activation of MMP-2 by MT1-MMP is required for 3-D invasiveness. Cell surface localization of MT1-MMP was depend on 3-D. MMP-2 expression was strongly correlated to invasiveness and regulated by epigenetics. We identified epigenetic factors and these target genes possibly involved in cancer malignancy.3) Cell surface Met was heterogeneously expressed in mammary epithelial cells and malignant melanomas. This might reflect invasive and malignant cell phenotypes.
All 2013 2012 2011 Other
All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (6 results) Book (1 results) Remarks (1 results)
Cytokine
Volume: XXX Issue: 3 Pages: 446-452
10.1016/j.cyto.2013.04.006
Cancer Lett
Volume: 335(2) Issue: 2 Pages: 472-478
10.1016/j.canlet.2013.03.008
120005254051
Circulation journal
Volume: XXX
Am J Physiol Gastrointest Liver Physiol.
Volume: 302 Issue: 4 Pages: 420-429
10.1152/ajpgi.00216.2011
Biochem Biophys Res Commun
Volume: 412 Issue: 1 Pages: 98-103
10.1016/j.bbrc.2011.07.050
120003308573
Am J Pathol
Volume: 179 Issue: 3 Pages: 1483-93
10.1016/j.ajpath.2011.05.060
Current Signal Transduction Therapy
Volume: 6 Pages: 191-199
http://dx.doi.org/10.2174/157436211795659964
Biochemical and Biophysical Research Communications
Volume: 412 Pages: 98-103
http://www.intechopen.com/books/advances-in-cancer-therapy/significance-mechanisms-and-progress-ofanticancerdrugs-targeting-hgf-met
http://www.kanazawa-u.ac.jp/~ganken/shuyoudoutaiseigyo/index.html