| Project/Area Number |
23790224
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General anatomy (including Histology/Embryology)
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | SUMO 化 / アルツハイマー病 / 小胞体ストレス / 細胞死 / 神経変性疾患 / SUMO化 / 国際研究者交流 / カナダ / トロント / 国際情報交流 / スモ化 |
|---|
| Research Abstract |
In this project, effects of SUMOylation on neural system has been investigated to elucidate the involvement of it in the pathogenesis of neural and neurodegenerative diseases. As results, SUMOylation should play important roles to maintain synaptic functions and protective function against the neural death pathway observed in neurodegenerative diseases, especially ER stress pathway. The data show that SUMOylation regulates CHOP expression, one of inducers of apoptosis. These results suggest that neural SUMOylation should work protectively against ER stress and regulates the synapse function in neural and neurodegenerative disease.
|
