| Project/Area Number |
23790226
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HARADA Akihiro 大阪大学, 大学院・医学系研究科, 教授 (40251441)
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| Research Collaborator |
NAKAJO Atsuhiro 大阪大学, 医学部医学科, 4回生
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | Rab8 / 上皮細胞 / Rab |
|---|
| Research Abstract |
We identified a novel effector protein for Rab8, namely Rab8BP using yeast two-hybrid method. Rab8BP was co-localized with Rab8 in intracellular compartments. When Rab8BP was knocked-down by RNAi, the localization of Rab8 was altered. The results suggest that Rab8BP regulates the activity of Rab8 by helping its proper localization.
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