Analysis of the regulatory mechanism and function of stathmin1 in the central nervous system
| Project/Area Number |
23790227
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Hamamatsu University School of Medicine (2013)
Osaka University (2011-2012) |
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Principal Investigator |
YAMADA Kohei 浜松医科大学, 子どものこころの発達研究センター, 講師 (50588879)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | stathmin1 / 神経 / リン酸化タンパク質 / 脳発達 / 周産期 / リン酸化 / 脳形成 / BDNF / 細胞骨格 / 神経発生 |
|---|
| Research Abstract |
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide involved in a variety of brain function. We demonstrated that PACAP regulates stathmin1 expression. Shumyatsky GP. et al. reported that mice without stathmin1 have deficiency in innate and learned fear. However, the detailed function and regulatory mechanism of stathmin1 in the central nervous system are unclear. In this study, we found that stathmin1 was phosphorylated during perinatal stage in the cortex. Phosphorylated stathmin1 was localized in the marginal zone of cortex, forming dot like fibers. In primary cultured neuron study, we detected dot-like phosphorylated stathmin1. And we indicated that BDNF was related to phosphorylation of stathmin1. PC12 cells over-expressed stathmin1 constitutive active form had longer thick neurites and numerous slight neurites as a filopodia. These results show that phosphorylated stathmin1 is related to filopodia or synapse constitution during perinatal period.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] DISC1 (disrupted-in-schizophrenia-1) regulates differentiation of oligodendrocytes.2014
Author(s)
Hattori T, Shimizu S, Koyama Y, Emoto H, Matsumoto Y, Kumamoto N, Yamada K, Takamura H, Matsuzaki S, Katayama T, Tohyama M, Ito A.
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Journal Title
PLoS One
Volume: 7;9(2)
Issue: 2
Pages: e88506-e88506
DOI
Related Report
Peer Reviewed
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[Journal Article] XLMR protein related to neurite extension (Xpn/KIAA2022) regulates cell-cell and cell-matrix adhesion and migration2013
Author(s)
Magome T, Hattori T, Taniguchi M, Ishikawa T, Miyata S, Yamada K, Takamura H, Matsuzaki S, Ito A, Tohyama M, Katayama T
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Journal Title
Neurochemistry International
Volume: 63
Issue: 6
Pages: 561-569
DOI
Related Report
Peer Reviewed
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[Journal Article] DBZ (DISC1-binding zinc finger protein)-deficient mice display abnormalities in basket cells in the somatosensory cortices.2013
Author(s)
Koyama Y, Hattori T, Shimizu S, Taniguchi M, Yamada K, Takamura H, Kumamoto N, Matsuzaki S, Ito A, Katayama T, Tohyama M.
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Journal Title
J Chem Neuroanat.
Volume: 53
Pages: 1-10
DOI
Related Report
Peer Reviewed
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