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Analysis of the regulatory mechanism and function of stathmin1 in the central nervous system

Research Project

Project/Area Number 23790227
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General anatomy (including Histology/Embryology)
Research InstitutionHamamatsu University School of Medicine (2013)
Osaka University (2011-2012)

Principal Investigator

YAMADA Kohei  浜松医科大学, 子どものこころの発達研究センター, 講師 (50588879)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsstathmin1 / 神経 / リン酸化タンパク質 / 脳発達 / 周産期 / リン酸化 / 脳形成 / BDNF / 細胞骨格 / 神経発生
Research Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide involved in a variety of brain function. We demonstrated that PACAP regulates stathmin1 expression. Shumyatsky GP. et al. reported that mice without stathmin1 have deficiency in innate and learned fear. However, the detailed function and regulatory mechanism of stathmin1 in the central nervous system are unclear. In this study, we found that stathmin1 was phosphorylated during perinatal stage in the cortex. Phosphorylated stathmin1 was localized in the marginal zone of cortex, forming dot like fibers. In primary cultured neuron study, we detected dot-like phosphorylated stathmin1. And we indicated that BDNF was related to phosphorylation of stathmin1. PC12 cells over-expressed stathmin1 constitutive active form had longer thick neurites and numerous slight neurites as a filopodia. These results show that phosphorylated stathmin1 is related to filopodia or synapse constitution during perinatal period.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (12 results)

All 2014 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (7 results)

  • [Journal Article] DISC1 (disrupted-in-schizophrenia-1) regulates differentiation of oligodendrocytes.2014

    • Author(s)
      Hattori T, Shimizu S, Koyama Y, Emoto H, Matsumoto Y, Kumamoto N, Yamada K, Takamura H, Matsuzaki S, Katayama T, Tohyama M, Ito A.
    • Journal Title

      PLoS One

      Volume: 7;9(2) Issue: 2 Pages: e88506-e88506

    • DOI

      10.1371/journal.pone.0088506

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] XLMR protein related to neurite extension (Xpn/KIAA2022) regulates cell-cell and cell-matrix adhesion and migration2013

    • Author(s)
      Magome T, Hattori T, Taniguchi M, Ishikawa T, Miyata S, Yamada K, Takamura H, Matsuzaki S, Ito A, Tohyama M, Katayama T
    • Journal Title

      Neurochemistry International

      Volume: 63 Issue: 6 Pages: 561-569

    • DOI

      10.1016/j.neuint.2013.09.011

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Revised conformational assignments and conformational evolution of tyrosine by laser desorption supersonic jet laser spectroscopy2013

    • Author(s)
      Y. Shimozono
    • Journal Title

      Phys. Chem. Chem. Phys.

      Volume: 15 Issue: 14 Pages: 5163-5175

    • DOI

      10.1039/c3cp43573c

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] DBZ (DISC1-binding zinc finger protein)-deficient mice display abnormalities in basket cells in the somatosensory cortices.2013

    • Author(s)
      Koyama Y, Hattori T, Shimizu S, Taniguchi M, Yamada K, Takamura H, Kumamoto N, Matsuzaki S, Ito A, Katayama T, Tohyama M.
    • Journal Title

      J Chem Neuroanat.

      Volume: 53 Pages: 1-10

    • DOI

      10.1016/j.jchemneu.2013.07.002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression.2012

    • Author(s)
      Takamura H, Koyama Y, Matsuzaki S, Yamada K, Hattori T, Miyata S, Takemoto K, Tohyama M, Katayama T.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 12 Pages: 12-12

    • DOI

      10.1371/journal.pone.0051912

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 中枢におけるリン酸化stathmin1の機能解析2013

    • Author(s)
      山田浩平、谷口学、松崎伸介、高村明考、服部剛志、遠山正彌、片山泰一
    • Organizer
      Neuro2013
    • Place of Presentation
      京都
    • Year and Date
      2013-06-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 中枢神経系におけるstathmin1の機能解析2012

    • Author(s)
      山田浩平、松崎伸介、新谷紀人、橋本均、馬場明道、片山泰一、遠山正彌
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨
    • Year and Date
      2012-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Implications for Human Diseases, Neuronal SUMOylation and Its Contributions to Form, Function and Neurodegenerative Diseases2012

    • Author(s)
      Shinsuke Matsuzaki, Kohei Yamada, Nicola St George-Hyslop, Brian Raught, Taiichi Katayama, Masaya Tohyama and Paul Fraser
    • Organizer
      6th Intl Conference SUMO, Ubiquitin, UBL Proteins
    • Place of Presentation
      Houston
    • Related Report
      2011 Research-status Report
  • [Presentation] 中枢神経系におけるstathmin1の機能解析2012

    • Author(s)
      山田浩平、松崎伸介、新谷紀人、橋本均、馬場明道、片山泰一、遠山正彌
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨市
    • Related Report
      2011 Research-status Report
  • [Presentation] C57/BL6 JマウスにおけるDisrupted-in-Schizophrenia 1(DISC1)の新規isoformの同定とそのmRNA発現解析2011

    • Author(s)
      宮武祐樹、山田浩平、高村明孝、服部剛志、小山佳久、谷口学、片山泰一、遠山正彌
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都市
    • Related Report
      2011 Research-status Report
  • [Presentation] Increased stathmin1 expression in the dentate gyrus causes abnormal axonal arborizations.

    • Author(s)
      Yamada Kohei, Matsuzaki Shinsuke, Hattori Tsuyoshi, Shintani Norihito, Tohyama Masaya, Katayama Taiichi, Suzuki Katsuaki and Mori Norio.
    • Organizer
      The 13th Hamamatsu-Kyungpook Joint Medical Symposium
    • Place of Presentation
      Kyungpook
    • Related Report
      2013 Annual Research Report
  • [Presentation] 中枢におけるリン酸化stathmin1の機能解析

    • Author(s)
      山田浩平、谷口学、松崎伸介、高村明考、服部剛志、遠山正彌、片山泰一、
    • Organizer
      Neuro2013
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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