| Project/Area Number |
23790228
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General anatomy (including Histology/Embryology)
|
|---|
| Research Institution | Ehime University |
|---|
Principal Investigator |
HARAGUCHI Ryuma 愛媛大学, 大学院・医学系研究科, 講師 (00423690)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KITAZAWA Sohei 愛媛大学, 大学院・医学系研究科, 教授 (90186239)
KITAZAWA Riko 愛媛大学, 大学院・医学系研究科, 准教授 (00273780)
YAMADA Gen 和歌山県立医科大学, 教授 (80174712)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 泌尿生殖器 / 平滑筋 / 組織系譜解析 |
|---|
| Research Abstract |
Congenital diseases of the urinary tract are frequently observed in infants. Such diseases present a number of developmental anomalies such as hydroureter and hydronephrosis. Although some genetically-modified mouse models of growth factor signaling genes reproduce urinary phenotypes, the pathogenic mechanisms remain obscure. Previous studies suggest that a portion of the cells in the external genitalia and bladder are derived from peri-cloacal mesenchymal cells that receive Hedgehog (Hh) signaling in the early developmental stages. We hypothesized that defects insuch progenitor cells, which give rise to urinary tract tissues, may be a cause of such diseases. Our study identified the essential embryonic stages for the pathogenesis of urinary tract phenotypes. These results suggested that Hh-responsive mesenchymal Bmp signaling maintains the population of peri-cloacal mesenchyme cells, which is essential for the development of the ureter and the upper urinary tract.
|
