Mechanisms underlying evolutionary architecture of primary sensory neurons in chordates

• Project/Area Number: 23790234
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Jichi Medical University
• Principal Investigator: YAJIMA Hiroshi 自治医科大学, 医学部, 講師 (10433583)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 発生 / 進化 / 分化 / 一次感覚神経 / 脊髄神経節 / 神経堤細胞 / エンハンサー / Six遺伝子

Research Abstract

We found 1) Six1 is a key regulator of transition from intramedullary primary sensory neurons to extramedullary sensory neurons during Xenopus development, 2) early expression of Six1 prevents the appearance of intramedullary sensory neurons in mouse spin

Research Products

• [Journal Article] Regulation of Six1 expression by evolutionarily conserved enhancers in tetrapods (2012)
  • Author(s): Sato S, Ikeda K, Shioi G, Nakao K, Yajima H, Kawakami K.
  • Journal Title: Dev Biol Volume: 368 Issue: 1 Pages: 95-108
  • DOI: 10.1016/j.ydbio.2012.05.023
  • Peer Reviewed
• [Presentation] 体幹部一次感覚神経の発生と進化の鍵因子 (2012)
  • Author(s): 矢嶋浩, 鈴木誠, 越智陽城, 池田啓子, 佐藤滋, 荻野肇, 上野直人, 川上潔
  • Organizer: 第24回 高遠・分子生物学シンポジウム
  • Place of Presentation: 高遠さくらホテル
  • Year and Date: 2012-08-23
• [Presentation] Key regulator for developmental and evolutionary switch from Rohon-Beard cells to dorsal root ganglia (2012)
  • Author(s): 矢嶋浩, 鈴木誠, 越智陽城, 池田啓子, 佐藤滋, 荻野肇, 上野直人, 川上潔
  • Organizer: Society for Developmental Biology 71st Annual Meeting
  • Place of Presentation: Hilton Bonaventure Hotel(カナダ・モントリオール)
  • Year and Date: 2012-07-21
• [Presentation] Key regulator for developmental and evolutionary switch from Rohon-Beard cells to dorsal root ganglia (2012)
  • Author(s): 矢嶋 浩
  • Organizer: Society for Developmental Biology 71st Annual Meeting
  • Place of Presentation: モントリオール
• [Presentation] 体幹部一次感覚神経の発生と進化の鍵因子 (2012)
  • Author(s): 矢嶋 浩
  • Organizer: 第24会 高遠分子生物学シンポジウム
  • Place of Presentation: 長野県伊那市高遠町
• [Presentation] Heterochronic shift of Six1 expression drives evolutionary transition of vertebrate primary sensory neurons (2011)
  • Author(s): 矢嶋浩, 鈴木誠, 越智陽城, 池田啓子, 佐藤滋, 荻野肇, 上野直人, 川上潔
  • Organizer: 第44回 日本発生生物学会年会
  • Place of Presentation: 沖縄コンベンションセンター
  • Year and Date: 2011-05-19
• [Presentation] Heterochronic shift of Six1 expression drives evolutionary transition of vertebrate primary sensory neurons (2011)
  • Author(s): 矢嶋 浩
  • Organizer: 第44回日本発生生物学会年会
  • Place of Presentation: 沖縄コンベンションセンター
• [Remarks] 自治医科大学・分子病態治療研究センター・細胞生物研究部
  • URL: http://www.jichi.ac.jp/biol/home.html
• [Remarks] 自治医科大学・研究シーズ集・研究者詳細
  • URL: http://rseeds.jichi.ac.jp/research_seeds/public/ResearchResultDetail.php?publicId=9f6lyICrrIM78bNVyQCS3U8LQcN2RS&resultCd=1&sectionCd=126
• [Remarks] 自治医科大学・分子病態治療研究センター・細胞生物研究部
  • URL: http://www.jichi.ac.jp/biol/home.html
• [Remarks] 自治医科大学・研究シーズ集・研究者詳細
  • URL: http://rseeds.jichi.ac.jp/research_seeds/public/ResearchResultDetail.php?publicId=9f6lyICrrIM78bNVyQCS3U8LQcN2RS&resultCd=1&sectionCd=126
• [Remarks]
  • URL: http://www.jichi.ac.jp/biol/home.html
• [Remarks]
  • URL: http://rseeds.jichi.ac.jp/research_seeds/public/ResearchResultDetail.php?publicId=9f6lyICrrIM78bNVyQCS3U8LQcN2RS&resultCd=1&sectionCd=126