Novel immunosuppressive protocol in whichdepleting donor dendritic-cells by anti-MHC-II antibodies.

• Project/Area Number: 23790235
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Dokkyo Medical University
• Principal Investigator: UETA Hisashi 獨協医科大学, 医学部, 准教授 (10364556)
• Project Period (FY): 2012 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 免疫組織学 / 樹状細胞 / cell trafficking / 移植免疫 / 免疫抑制 / 抗体 / MHC-II / ラット / MHC class II (MHC-II) / 肝臓

Research Abstract

We identified 2 types of immunogeneic dendritic-cells in rat liver and developed a novel immunosuppressive protocol by depleting them using antibody against MHC-II.

Research Products

• [Journal Article] Two Immunogenic Passenger Dendritic Cell Subsets in the Rat Liver Have Distinct Trafficking Patterns and Radiosensitivities (2012)
  • Author(s): *Bin Yu and *Hisashi Ueta *Equal contribution
  • Journal Title: Hepatology Volume: 56 Issue: 4 Pages: 1532-1545
  • DOI: 10.1002/hep.25795
  • Peer Reviewed
• [Presentation] Two distinct immunogenic passenger cDC subsets in rat liver graft rejection (2012)
  • Author(s): Ueta H, Kitazawa Y, Sawanobori Y, Matsuno K
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸市
• [Presentation] Trafficking of two immunogenic conventional DC subsets in the liver (2012)
  • Author(s): Ueta H, Yu B, Kitazawa Y, Sawanobori Y, Matsuno K
  • Organizer: The 12th International Symposium on Dendritic Cells
  • Place of Presentation: Daegu, Korea
• [Presentation] Two immunogenic passenger dendritic-cell subsets in the rat liver have distinct trafficking patterns and radiosensitivities (2012)
  • Author(s): 上田祐司, 松野健二郎, 沢登祥史, 北沢祐 介 , 余 斌
  • Organizer: 第117回 日本解剖学会全国学術集会
  • Place of Presentation: 甲府市
• [Presentation] Two distinct immunogenic passenger cDC subsets in rat liver graft rejection (2012)
  • Author(s): Ueta H, Kitazawa Y, Sawanobori Y, Matsuno K
  • Organizer: 第41回 日本免疫学会学術集会
  • Place of Presentation: 神戸市（兵庫県）
• [Presentation] Trafficking of two immunogenic conventional DC subsets in the liver, The 12th International Symposium on Dendritic Cells (2012)
  • Author(s): Ueta H, Yu B, Kitazawa Y, Sawanobori Y, Matsuno K
  • Organizer: The 12th International Symposium on Dendritic Cells
  • Place of Presentation: テグ市（大韓民国）
• [Remarks]
  • URL: http://macro.dokkyomed.ac.jp/index.html