Searching for substrates of lysosomal cathepsins

• Project/Area Number: 23790238
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Juntendo University
• Principal Investigator: KOIKE Masato 順天堂大学, 医学部, 准教授 (80347210)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: リソソーム / カテプシン D / ノックアウトマウス / 基質特異性 / ミクログリア / カテプシン C / カテプシンD / 遺伝子欠損マウス / リソソーム蓄積症 / 神経性セロイドリポフスチン蓄積症 / 基質 / カテプシンC / カテプシンL / カテプシンB

Research Abstract

For the discovery of substrates for cathepsin D, whole brain lysates from cathepsin D deficient (CD-/-) and the control littermate mice were separated by two-dimensional gel electrophoresis. Several proteins increased in CD-/- mouse brains were identified by mass spectrometry (MS). However immunohistochemical analyses revealed that some of the identified proteins were enriched in active microglia or astrocytes in CD-/- brains. We also found that the protein amount and activity of cathepsin C, whic h is a lysosomal protease and reported to be cleaved by cathepin D in vivo, was increased. However cathepsin C was also detected in activated microglia in CD-/- brains.

Research Products

• [Journal Article] Enrichment of GABARAP relative to LC3 in the axonal initial segments of neurons (2013)
  • Author(s): Koike, M.*, Tanida, I.*, Nanao, T., Tada, N., Iwata, J., Ueno, T., Kominami, E., Uchiyama, Y.
  • Journal Title: PLoS One Volume: 8(5)
• [Journal Article] ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons (2013)
  • Author(s): Matsui, H.*, Sato, F.*, Sato, S., Koike, M., Taruno, Y., Saiki, S., Funayama, M., Ito, H., Taniguchi, Y., Uemura, N., Toyoda, A., Sakaki, Y., Takeda, S., Uchiyama, Y., Hattori, N., Takahashi, R
  • Journal Title: FEBS letters Volume: 587(9) Pages: 1316-25
• [Journal Article] Biogenesis and proteolytic processing of lysosomal DNase II (2013)
  • Author(s): Ohkouchi, S., Shibata, M., Sasaki, M., Koike, M., Saftig, P., Peters, C., Nagata, S., Uchiyama, Y.
  • Journal Title: PLoS One Volume: 8(3)
• [Journal Article] Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous systems. (2013)
  • Author(s): Koike, M., Shibata, M., Ezaki, J., Peters, C., Saftig, P., Kominami, E., Uchiyama, Y.
  • Journal Title: Eur. J. Neurosci. Volume: 37(5) Pages: 816-20
• [Journal Article] Resveratrol affects undifferentiated and differentiated PC12 cells differently, particularly with respect to possible differences in mitochondrial and autophagic functions (2013)
  • Author(s): Hayakawa, N., Shiozaki, M., Shibata, M., Koike, M., Uchiyama, Y., Gotow, T
  • Journal Title: Eur. J. Cell Biol Volume: 92(1) Pages: 30-43
• [Journal Article] Enrichment of GABARAP relative to LC3 in the axonal initial segments of neurons. (2013)
  • Author(s): Koike, M., Tanida, I., Nanao, T., Tada, N., Iwata, J., Ueno, T., Kominami, E., Uchiyama, Y.
  • Journal Title: PLoS One Volume: 印刷中
  • Peer Reviewed
• [Journal Article] ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons. (2013)
  • Author(s): Matsui H, Sato F, Sato S, Koike M, Taruno Y, Saiki S, Funayama M, Ito H, Taniguchi Y, Uemura N, Toyoda A, Sakaki Y, Takeda S, Uchiyama Y, Hattori N, Takahashi R.
  • Journal Title: FEBS Lett Volume: 587(9) Issue: 9 Pages: 1316-1325
  • DOI: 10.1016/j.febslet.2013.02.046
  • Peer Reviewed / Open Access
• [Journal Article] Biogenesis and Proteolytic Processing of Lysosomal DNase II. (2013)
  • Author(s): Ohkouchi, S., Shibata, M., Sasaki, M., Koike, M., Safig, P., Peters, C., Nagata, S., and Uchiyama, Y.
  • Journal Title: PloS One Volume: 8 Issue: 3 Pages: e59148-e59148
  • DOI: 10.1371/journal.pone.0059148
  • Peer Reviewed
• [Journal Article] Resveratrol affects undifferentiated and differentiated PC12 cells differently, particularly with respect to possible differences in mitochondrial and autophagic fuctions (2013)
  • Author(s): Hyakawa N., Shiozaki M., Shibata M., Koike M., Uchiyama Y., Matsuura N., Gotow T.
  • Journal Title: Eur. J. Cell Biol Volume: 92 Issue: 1 Pages: 30-43
  • DOI: 10.1016/j.ejcb.2012.10.002
  • Peer Reviewed
• [Journal Article] c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis. (2013)
  • Author(s): Piao X
  • Journal Title: Sci Signal Volume: ra93 Issue: 255
  • DOI: 10.1126/scisignal.2003558
  • Peer Reviewed
• [Journal Article] c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis. (2012)
  • Author(s): Piao, X., Komazawa-Sakon, S., Nishida, T., Koike, M., Piao JH., Ehlken, H., Kurihara, H., Hara, M., van Rooijen, N., Schutz, G., Ohmuraya, M., Uchiyama, Y., Yagita, H., Okumura, K., He YW., Nakano, H.
  • Journal Title: Sci. Signal 5 Volume: 255
• [Journal Article] Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis. (2012)
  • Author(s): Tashiro Y.*, Urushitani, M.*, Inoue, H., Koike, M., Uchiyama, Y., Komatsu, M., Tanaka, K., Yamazaki, M., Abe, M., Misawa, H., Sakimura, K., Ito, H., Takahashi, R
  • Journal Title: J. Biol. Chem. Volume: 109(43) Pages: 42984-94
• [Journal Article] Mitochondrial dysfunction with increased oxidative stress and α-synuclein accumulation inPARK2 iPSC-derived neurons and postmortem brain. (2012)
  • Author(s): Imaizumi, Y., Okada, Y., Akamatsu, W., Koike, M., Kuzumaki, N., Hayakawa, H., Nihira, T., Kobayashi, T., Ohyama, M., Sato, S., Takanashi, M., Funayama, M., Hirayama, A., Soga, T., Hishiki, T., Suematsu, M., Yagi, T., Ito, D., Kosakai, A., Hayashi, K., Shouji, M., Nakanishi, A., Suzuki, N., Mizuno, Y., Mizushima, N., Amagai, M., Uchiyama, Y., Mochizuki, H., Hattori, N., Okano, H.
  • Journal Title: Molecular Brain Volume: 5(1) Pages: 35-35
• [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (2012)
  • Author(s): Klionsky, D.J. and 1428 authors.
  • Journal Title: Autophagy Volume: 8(4) Pages: 445-544
• [Journal Article] The development of Purkinje cell degeneration in a knockin mouse model reveals lysosomal involvement in the pathogenesis of SCA6 (2012)
  • Author(s): Unno, T., Wakamori, M., Koike, M.,Uchiyama, Y., Ishikawa, K., Kubota, H., Yoshida, T., Sasakawa, H., Peters, C., Mizusawa, H., Watase, K
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 109(43) Pages: 17693-8
• [Journal Article] Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5 (2012)
  • Author(s): Sekine, S., Kanamaru, Y., Koike, M., Nishihara, A., Okada, M., Kinoshita, H., Kamiyama, M., Maruyama, J., Uchiyama, Y., Ishihara, N., Takeda, K., Ichijo, H.
  • Journal Title: J. Biol. Chem. Volume: 287(41) Pages: 34635-45
• [Journal Article] 神経性セロイドリポフスチン蓄積症における"異常なリソソーム"のオートファジーによる処理 (2012)
  • Author(s): 小池正人、内山安男
  • Journal Title: 生体の科学 Volume: 63(5) Pages: 404-5
• [Journal Article] Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis (2012)
  • Author(s): Y. Tashiro
  • Journal Title: Journal of Biological Chemistry Volume: 287 Issue: 51 Pages: 42984-42994
  • DOI: 10.1074/jbc.m112.417600
  • Peer Reviewed
• [Journal Article] Mitochondrial dysfunction associated with increased oxidative stress and -synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. (2012)
  • Author(s): Imaizumi Y
  • Journal Title: Mol Brain Volume: 5 Issue: 1 Pages: 35-35
  • DOI: 10.1186/1756-6606-5-35
  • Peer Reviewed
• [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy. (2012)
  • Author(s): Klionsky DJ et al.
  • Journal Title: Autophagy Volume: 8 Pages: 445-544
  • Peer Reviewed
• [Journal Article] Development of Purkinje cell degeneration in a knockin mouse model reveals lysosomal involvement in the pathogenesis of SCA6. (2012)
  • Author(s): Unno, T., Wakamori, M., Koike, M., Uchiyama, Y., Ishikawa, K., Kubota, H., Yoshida, T., Sasakawa, H., Peters, C., Mizusawa, H. and Watase K
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 109(43) Issue: 43 Pages: 17693-17698
  • DOI: 10.1073/pnas.1212786109
  • Peer Reviewed
• [Journal Article] Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5 (2012)
  • Author(s): Sekine, S., et al.
  • Journal Title: J. Biol. Chem. Volume: 287 Issue: 41 Pages: 34635-34645
  • DOI: 10.1074/jbc.m112.357509
  • Peer Reviewed
• [Journal Article] 神経性セロイドリポフスチン蓄積症における”異常なリソソーム”のオートファジーによる処理 (2012)
  • Author(s): 小池正人、内山安男
  • Journal Title: 生体の科学 Volume: 63 Pages: 404-5
• [Journal Article] Grafted human induced pluripotent stem-cell-derived neurospheres promotes motor functional recovery after spinal cord injury in mice (2011)
  • Author(s): Nori, S., Okada, Y., Yasuda, A., Tsuji, O., Takahashi, Y., Kobayashi, Y., Fujiyoshi, K., Koike, M., Uchiyama, Y., Ikeda, E., Toyama, Y., Yamanaka, S., Nakamura, M., Okano, H.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 108(40) Pages: 16825-30
• [Journal Article] Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes (2011)
  • Author(s): Uchida, Y., Hasegawa, J., Chinnapen, D., Inoue, T., Okazaki, S., Kato, R., Wakatsuki, S., Misaki, R., Koike, M., Uchiyama, Y., Iemura, S., Natsume, T., Kuwahara, R., Nakagawa, T., Nishikawa, K., Mukai, K., Miyoshi, E., Taniguchi, N., Sheff, D., Lencer, W.I., Taguchi, T., Arai H
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 108(38) Pages: 15846-51
• [Journal Article] Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1 (2011)
  • Author(s): Koyanagi, M., Asahara, S., Matsuda, T., Hashimoto, N., Shigeyama, Y., Shibutani, Y., Kanno, A., Fuchita, M., Mikami, T., Hosooka, T., Inoue, H., Matsumoto, M., Koike, M., Uchiyama, Y., Noda, T., Seino, S., Kasuga, M., Kido, Y
  • Journal Title: PLoS One Volume: 6(8)
• [Journal Article] Closer association of mitochondria with lipid droplets in hepatocytes and activation of Kupffer cells in resveratrol-treated senescence-accelerated mice (2011)
  • Author(s): Shiozaki, M., Hayakawa, N., Shibata, M., Koike, M., Uchiyama, Y., Gotow, T.
  • Journal Title: Histochem. Cell Biol Volume: 136(4) Pages: 475-89
• [Journal Article] Dissociation and dispersion of claudin-3 from the tight junction could be one of the most sensitive indicators of reflux esophagitis in a rat model of the disease (2011)
  • Author(s): Oguro, M., Koike, M., Ueno, T., Asaoka, D., Mori, H., Nagahara, A., Uchiyama, Y., Watanabe, S.
  • Journal Title: J. Gastroenterol. Volume: 46(5) Pages: 629-38
  • NAID: 10029029126
• [Journal Article] リソソームプロテアーゼの多様性とその病態生理学的役割 (2011)
  • Author(s): 小池正人、内山安男
  • Journal Title: 実験医学増刊号 Volume: 29(12) Pages: 1903-1908
• [Journal Article] Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1 (2011)
  • Author(s): Koyanagi Mら
  • Journal Title: PLos One Volume: 6
  • Peer Reviewed
• [Journal Article] Dissociation and dispersion of claudin-3 from the tight junction could be one of the most sensitive indicators of reflux esophagitis in a rat model of the disease (2011)
  • Author(s): Oguro Mら
  • Journal Title: J Gastroenterol. Volume: 46 Pages: 629-638
  • Peer Reviewed
• [Journal Article] Closer association of mitochondria with lipid droplets in hepatocytes and activation of Kupffer cells in resveratrol-treated senescence-accelerated mice (2011)
  • Author(s): Shiozaki, Mら
  • Journal Title: Histochem. Cell Biol. Volume: 136 Pages: 475-489
  • Peer Reviewed
• [Journal Article] Intracellular Phosphatidylserine Regulates Membrane Traffic Through Endosomes (2011)
  • Author(s): Uchida, Yら
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 108 Pages: 15846-15851
  • Peer Reviewed
• [Journal Article] Grafted human induced pluripotent stem cell-derived neurospheres promotes motor functional recovery after spinal cord injury in mice (2011)
  • Author(s): Nori, Sら
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 108 Pages: 16825-16830
  • Peer Reviewed
• [Journal Article] Ultrastructural analyses of the rat esophageal stratified epithelium under normal conditions and chronic reflux esophagitis
  • Author(s): Mori, H.*, Koike, M.*, Gotow, T., Ichimura, K., Asaoka, D., Oguro, M., Nagahara, A., Ueno, T., Uchiyama, Y., Watanabe, S
  • Journal Title: Arch. Histol. Cytol Volume: (in press)
  • NAID: 130005087019
• [Presentation] Genetic dissection of the role of cathepsin D in mouse central nervous system (2012)
  • Author(s): Masato Koike, Masahiro Shibata, Takehiko Sunabori, Kenji Sakimura, Yasuo Uchiyama
  • Organizer: 6th International Symposium on Autophagy
  • Place of Presentation: 万国津梁館
• [Presentation] カテプシンBDダブルノックアウトマウスの中枢神経系の形態学的解析 (2012)
  • Author(s): 小池正人、山口隼司、内山安男
  • Organizer: 第17回グリアクラブ
  • Place of Presentation: ヒルトンニセコビリッジ
• [Presentation] 正常および老齢マウス脳におけるリソゾームカテプシン C の分布 (2012)
  • Author(s): 小池正人、内山安男
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
• [Presentation] ほ乳類 Atg9AmRNA ノックダウンHeLa 細胞について/A study on Atg9AmRNA-knockdown HeLa cells (2012)
  • Author(s): 多村博澄、佐々木光穂、小池正人、内山安男
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
• [Presentation] 腎虚血尿細管傷害におけるオートファジー・リソソーム系の関わりについて (2012)
  • Author(s): 鈴木ちぐれら
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
• [Presentation] Protective effects of hyaluronan tetrasaccharide on hippocampal pyramidal neurons in neonatal mouse after hypoxic-ischemic injury (2012)
  • Author(s): Sunabori Takehiko, Masato Koike, Yasuo Uchiyama
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
• [Presentation] カテプシンD欠損に伴う神経性ロイドリポフスチン蓄積症の病態形成にオートファジーが果たす役割について (2011)
  • Author(s): 小池正人、内山安男
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 神経分化と造腫瘍性から迫るヒトiPS細胞の品質評価 (2011)
  • Author(s): 岡田洋平ら
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 虚血生侵襲に対するヒアルロン酸４糖の神経細胞保護効果の検討 (2011)
  • Author(s): 砂堀毅彦、小池正人、内山安男
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Possible roles of LC3, ubiquitin, and P62 and/or Nbr1 in the accumulation of lysosomes in neurons deficient in Cathepsin D (2011)
  • Author(s): Masato Koike, Yasuo Uchiyama
  • Organizer: 41st Annual Meeting Society for Neuroscience
  • Place of Presentation: ワシントン・コンベンション・センター
• [Presentation] Protective effects of hyaluronan tetrasaccharide on hippocampal pyramidal neurons in neonatal mouse brains after hypoxic-ischemic injury (2011)
  • Author(s): Sunabori Takehiko, Masato Koike, Yasuo Uchiyama
  • Organizer: 41st Annual Meeting Society for Neuroscience
  • Place of Presentation: ワシントン・コンベンション・センター
• [Presentation] New neurons use Slit 1 to maintain astrocytic tunnels for their rapid migration in the adult brain (2011)
  • Author(s): Naoko Kanekoら
  • Organizer: 41st Annual Meeting Society for Neuroscience
  • Place of Presentation: ワシントン・コンベンション・センター
• [Presentation] Different expression patterns of cathepsin C/dipeptidyl peptidase I in normal, patholgical and aged cenral nervous system of mice
  • Author(s): M. KOIKE, Y. UCHIYAMA.
  • Organizer: 14th International Congress of Histochemistry and Cytochemistry
  • Place of Presentation: 京都国際会議場
• [Presentation] レスベラトロールは未分化PC12細胞では障害的に分化PC12細胞では保護的に作用する
  • Author(s): 早川直哉、塩崎元子、柴田昌宏、小池正人、内山安男、後藤隆洋
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] ヒアルロン酸4糖は低酸素/脳虚血負荷依存性にToll様受容体2／4の活性化を抑制することで海馬錐体細胞に神経保護効果を示す
  • Author(s): 砂堀毅彦、小池正人、内山安男
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] 正常・老齢・各種傷害時のマウス脳におけるリソソームカテプシンCの分布
  • Author(s): 小池正人、内山安男
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Mitochondrial dysfunction and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain of cell donor
  • Author(s): Y. IMAIZUMI, Y. OKADA, W. AKAMATSU, M. KOIKE, H. HAYAKAWA, N. KUZUMAKI, M. OHYAMA, D. ITO, Y. UCHIYAMA, H. MOCHIZUKI, N. HATTORI, H. OKANO
  • Organizer: 42nd Annual Meeting Society for Neuroscience
  • Place of Presentation: ニューオーリンズ
• [Presentation] Different expression patterns of cathepsin C/dipeptidyl peptidase I in normal, patholgical and aged cenral nervous system of mice
  • Author(s): M. KOIKE, Y. UCHIYAMA
  • Organizer: 42nd Annual Meeting Society for Neuroscience
  • Place of Presentation: ニューオーリンズ
• [Presentation] Grafted unsafe human iPSC-derived neurospheres promote temporal functional recovery in spinal cord injured mice, followed by neoplasm formation and motor deterioration after long term observation
  • Author(s): S. NORI, Y. OKADA, G. ITAKURA, Y. KOBAYASHI, A. YASUDA, M. KOIKE, Y. UCHIYAMA, E. IKEDA, Y. TOYAMA, S. YAMANAKA, H. OKANO, M. NAKAMURA
  • Organizer: 42nd Annual Meeting Society for Neuroscience
  • Place of Presentation: ニューオーリンズ
• [Presentation] PC12 cells are influenced differently by resveratrol depending on their differentiation
  • Author(s): N. HAYAKAWA, M. SHIOZAKI, M. SHIBATA, M. KOIKE, Y. UCHIYAMA, T. GOTOW
  • Organizer: 42nd Annual Meeting Society for Neuroscience
  • Place of Presentation: ニューオーリンズ
• [Presentation] Characteristic differences between Purkinje cells specifically deficient in cathepsin D and Atg7
  • Author(s): 小池正人、柴田昌弘、砂堀毅彦、崎村健司、内山安男
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: サンポートホール高松、かがわ国際会議場
• [Presentation] 初代培養神経細胞の成熟過程におけるリソソームの局在動態について
  • Author(s): 七尾友久、小池正人、山口隼司、砂堀毅彦、佐々木光穂、内山安男
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: サンポートホール高松、かがわ国際会議場
• [Presentation] 軸索終末部に置けるAtg9Aを含む小胞の膜成分の精製および解析
  • Author(s): 山口隼司、佐々木光穂、小池正人、七尾友久、砂堀毅彦、内山安男
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: サンポートホール高松、かがわ国際会議場
• [Presentation] レスベラトロールによるミトコンドリア／オートファジー機能制御と細胞寿命との関係
  • Author(s): 早川直哉、森本美幸、柴田昌弘、小池正人、内山安男
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: サンポートホール高松、かがわ国際会議場
• [Presentation] オートファジー／リソソームプロテアーゼの腎虚血再灌流尿細管傷害における役割について
  • Author(s): 小池正人、柴田昌弘、砂堀毅彦、崎村健司、内山安男
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: サンポートホール高松、かがわ国際会議場
• [Book] 「リソソーム内の分解機構」オートファジー 生命をささえる細胞の自己分解システム (水島昇・吉森保編集) (2012)
  • Author(s): 小池正人、内山安男
  • Publisher: 化学同人
• [Book] オートファジー 生命をささえる細胞の自己分解システム (2012)
  • Author(s): 小池正人、内山安男
  • Publisher: 化学同人
• [Book] 「マウス低酸素-脳虚血負荷後の神経細胞死の遺伝学的検討」ブレインサイエンスレビュー2011 (伊藤正男・川合述史編集) (2011)
  • Author(s): 小池正人
  • Publisher: クバプロ
• [Remarks]
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/shinkei_kozo/index.html