Inner Mitochondrial Maxi-K+ Channels in Neonatal Renal Tubular Cells: Novel Therapeutic Targets to Control Apoptosis
| Project/Area Number |
23790241
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General physiology
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
KAZAMA Itsuro 東北大学, 医学(系)研究科(研究院), 助教 (60593978)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | Maxi-Kチャネル / ミトプラスト / 腎臓 / 発生 / イオンチャネル |
|---|
| Research Abstract |
In developing kidneys, the total cell population is partly regulated by apoptosis. Despite our understanding of the molecular involvement in the regulatory pathway of apoptosis, we know little about the physiological involvement. Cardiomyocytes express large conductance voltage- and Ca2+-activated K+ (Maxi-K+) channels in their inner mitochondrial membranes. Triggering the mitochondrial K+ influx necessary to inhibit apoptosis, the channels play cytoprotective roles during ischemic injury. Since proximal tubular cells in neonatal kidneys are physiologically under hypoxic stress, and since the channel activity is stimulated by hypoxia, those cells would share the same regulatory mechanism of apoptosis with ischemic cardiomyocytes. Therefore, we hypothesize here that the proximal tubular cells in neonatal kidneys would also express the maxi-K+ channels in their inner mitochondrial membranes, and that the channels would play regulatory roles in apoptosis.
|
Report
(4 results)
Research Products
(38 results)
-
[Journal Article] Decreased Expression of a Novel Prostaglandin Transporter, OAT-PG, Facilitates Renocortical PGE2 Accumulation during Rat Pregnancy2013
Author(s)
Kazama I, Matsubara M, Kanai Y, Hatano R, Asano S, Endo Y, Toyama H, Ejima Y, Kurosawa S, Maruyama Y
-
Journal Title
Gynecol Obstet Invest
Volume: 76
Pages: 163-170
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
