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(Pro)renin receptor in cerebral, cardiac and renal diseases

Research Project

Project/Area Number 23790242
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionTohoku University

Principal Investigator

HIROSE Takuo  東北大学, 大学院・医学系研究科, 非常勤講師 (20599302)

Research Collaborator IMAI Yutaka  東北大学, 大学院・薬学研究科, 教授 (40133946)
TOTSUNE Kazuhito  東北大学, 大学院・薬学研究科, 客員教授 (10217515)
TAKAHASHI Kazuhiro  東北大学, 大学院・医学系研究科, 教授 (80241628)
MORI Takefumi  東北大学, 大学院・医学系研究科, 准教授 (40375001)
MORI Nobuyoshi  東北大学, 大学院・医学系研究科, 助教 (50463790)
GENEVIEVE NGUYEN  College de France, Center for Interdisciplinary Research in Biology, Director
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords(プロ)レニン受容体 / レニン・アンジオテンシン系 / 生理活性物質 / 発現・制御 / 腎障害 / 生理活性
Research Abstract

The aim of this study is to clarify the roles of (pro)renin receptor in cerebral, cardiac and renal diseases. We have demonstrated that expression of (pro)renin receptor protein in mouse kidney is increased after dehydration or high salt diet. We also showed that (pro)renin receptor regulates vesicular pH. Plasma soluble (pro)renin receptor concentration is increased in the patients of congestive heart failure and chronic renalfailure. These observations suggest that (pro)renin receptor has crucial roles in organ homeostasis and cerebral, cardiac and renal diseases.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (34 results)

All 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (24 results) (of which Invited: 1 results) Book (2 results) Remarks (1 results)

  • [Journal Article] <i>In Situ</i> Hybridization Method Reveals (Pro)renin Receptor Expressing Cells in the Pituitary Gland of Rats: Correlation with Anterior Pituitary Hormones2013

    • Author(s)
      Takahashi K, Yatabe M, Fujiwara K, Hirose T, Totsune K, Yashiro T.
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 46 Issue: 1 Pages: 47-50

    • DOI

      10.1267/ahc.12030

    • NAID

      130003361068

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of (pro)renin receptor in human erythroid cell lines and its increased protein accumulation by interferon-γ2012

    • Author(s)
      Kaneko K, Nishiyama H, Ohba K, Shibasaki A, Hirose T, Totsune K, Furuyama K, Takahashi K
    • Journal Title

      Peptides

      Volume: 37 Issue: 2 Pages: 285-289

    • DOI

      10.1016/j.peptides.2012.07.015

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma renin activity and the aldosterone-to-renin ratio are associated with the development of chronic kidney disease: the Ohasama study2012

    • Author(s)
      Terata S,Kikuya M,Satoh M,Ohkubo T, Hashimoto T,Hara A,Hirose T, Obara T, Metoki H,Inoue R,Asayama K,Kanno A, Totsune K,Hoshi H,Satoh H,Sato H,Imai Y.
    • Journal Title

      J Hypertens

      Volume: 25 Pages: 1632-1638

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma renin activity and the aldosterone-to-renin ratio are associated with the development of chronic kidney disease: The Ohasama Study2012

    • Author(s)
      Terata S, Kikuya M, Satoh M, Ohkubo T, Hashimoto T, Hara A, Hirose T, Obara T, Metoki H, Inoue R, Asayama K, Kanno A, Totsune K, Hoshi H, Satoh H, Sato H, Imai Y
    • Journal Title

      J Hypertens

      Volume: 30 Issue: 8 Pages: 1632

    • DOI

      10.1097/hjh.0b013e328354f65b

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aldosterone-to-renin ratio as a predictor of stroke under conditions of high sodium intake: The ohasama study2012

    • Author(s)
      Satoh M, Kikuya M, Ohkubo T, Mori T, Metoki H, Hara A, Utsugi MT, Hashimoto T, Hirose T, Obara T, Inoue R, Asayama K, Kanno A, Totsune K, Hoshi H, Satoh H, Imai Y.
    • Journal Title

      Am J Hypertens

      Volume: 25 Issue: 7 Pages: 777

    • DOI

      10.1038/ajh.2012.33

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women: The Ohasama study2011

    • Author(s)
      Hirose T, Hashimoto M, Totsune K, Metoki H, Hara A, Satoh M, Kikuya M, Ohkubo T, Asayama K, Kondo T, Kamide K, Katsuya T, Ogihara T, Izumi S, Rakugi H, Takahashi K, Imai Y.
    • Journal Title

      Hypertens Resociation of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women : the Ohasama study

      Volume: 34 Issue: 4 Pages: 530

    • DOI

      10.1038/hr.2010.274

    • NAID

      10031163212

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aldosterone-to-renin ratio and nocturnal blood pressure decline in a general population: The Ohasama study2011

    • Author(s)
      Satoh M, Kikuya M, Ohkubo T, Mori T, Metoki H, Hashimoto T, Hara A, Utsugi MT, Hirose T, Obara T, Inoue R, Asayama K, Kanno A, Totsune K, Hoshi H, Satoh H, Imai Y.
    • Journal Title

      J Hypertens

      Volume: 29 Issue: 10 Pages: 1940

    • DOI

      10.1097/hjh.0b013e32834ab46a

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] (プロ)レニン受容体とWntシグナル2013

    • Author(s)
      廣瀬卓男,Genevieve Nguyen
    • Organizer
      第86回日本内分泌学会総会
    • Place of Presentation
      宮城県仙台市(招待講演)
    • Year and Date
      2013-04-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Functional (pro)renin receptor in human lymphocytes and monocytes2012

    • Author(s)
      Kaori Narumi,Takuo Hirose, Emiko Sato, Mayuko Ishikawa,Kiyomi Kisu,Takefumi Mori, Sadayoshi Ito
    • Organizer
      German Society of Hypertension2012
    • Place of Presentation
      Berlin,Germany (口演)
    • Year and Date
      2012-12-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Increased expression of pro)renin receptor in remnant kidney of5/6 nephrectomized rats2012

    • Author(s)
      Takuo Hirose, Genevieve Nguyen, Kazuhito Totsune
    • Organizer
      1st German French Symposium in Berlin
    • Place of Presentation
      Berlin,Germany (ポスター)
    • Year and Date
      2012-10-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 副腎腫瘍における(プロ)レニン受容体mRNA発現の検討:アルドステロン産生副腎皮質腺腫における発現増加2012

    • Author(s)
      山本肇,金子桐子,大場浩史,森本玲,廣瀬卓男,佐藤文俊,戸恒和人,高橋和広
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      愛知県名古屋市(ポスター)
    • Year and Date
      2012-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒトリンパ球における(プロ)レニン受容体の検討2012

    • Author(s)
      鳴海かほり,森建文,佐藤恵美子,石川繭子,廣瀬卓男,石井智徳,伊藤貞嘉
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      神奈川県横浜市(口演)
    • Year and Date
      2012-06-03
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒトリンパ球に存在する(プロ)レニン受容体の機能について2012

    • Author(s)
      鳴海かほり,森建文,石川繭子,廣瀬卓男,石井智徳,伊藤貞嘉
    • Organizer
      第85回日本内分泌学会学術総会
    • Place of Presentation
      愛知県名古屋市(ポスター)
    • Year and Date
      2012-04-21
    • Related Report
      2012 Final Research Report
  • [Presentation] The role of (pro)renin receptor in the cerebral cortex2012

    • Author(s)
      Takuo Hirose, Alfredo Cabrera-Socorro, Hager Tabka,Sabrina Martin,Matthias Groszer,Genevieve Nguyen
    • Organizer
      4th (pro)renin receptor forum in Japan '12
    • Place of Presentation
      宮城県仙台市(招待講演)
    • Year and Date
      2012-03-20
    • Related Report
      2012 Final Research Report
  • [Presentation] The role of (pro)renin receptor in the cerebral cortex2012

    • Author(s)
      Takuo Hirose, Alfredo Cabrera-Socorro, Hager Tabka, Sabrina Martin, Matthias Groszer, Genevieve Nguyen
    • Organizer
      4th (pro)renin receptor forum in Japan '12(招待講演)
    • Place of Presentation
      仙台
    • Related Report
      2011 Research-status Report
  • [Presentation] Dissecting the role of PRR in the cerebral cortex2011

    • Author(s)
      Alfredo Cabrera-Soccoro,Takuo Hirose
    • Organizer
      P2R symposium
    • Place of Presentation
      Paris,France (招待講演)
    • Year and Date
      2011-12-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Immunoreactive (pro)renin receptor in plasma and urine2011

    • Author(s)
      Kazuhito Totsune,Takuo Hirose, Nobuyoshi Mori,Kei Asayama,Masahiro Kikuya,Osamu Murakami,Yutaka Imai, Kazuhiro Takahashi
    • Organizer
      P2R symposium
    • Place of Presentation
      Paris, France (招待講演)
    • Year and Date
      2011-12-05
    • Related Report
      2012 Final Research Report
  • [Presentation] (Pro)renin receptor-like immunoreactivity in patients with chronic renal failure2011

    • Author(s)
      Kazuhito Totsune,Takuo Hirose,Hirohito Metoki,Kei Asayama,Masahiro Kikuya,Osamu Murakami,Yutaka Imai,Kazuhiro Takahashi
    • Organizer
      American Society of Nephrology Renal Week 2011
    • Place of Presentation
      Philadelphia,USA (ポスター)
    • Year and Date
      2011-11-12
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト血漿中(プロ)レニン受容体の検討2011

    • Author(s)
      戸恒和人,廣瀬卓男,森信芳,浅山敬,菊谷昌浩,大久保孝義,高橋和広,今井潤
    • Organizer
      第54回日本腎臓学会総会
    • Place of Presentation
      神奈川県横浜市(口演)
    • Year and Date
      2011-06-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 血漿中(プロ)レニン受容体可溶性成分の検討2011

    • Author(s)
      戸恒和人,廣瀬卓男,森信芳,菊谷昌浩,大久保孝義,高橋和広,今井潤
    • Organizer
      第84回日本内分泌学会総会
    • Place of Presentation
      兵庫県神戸市(ポスター)
    • Year and Date
      2011-04-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 血漿中(プロ)レニン受容体可溶性成分の検討2011

    • Author(s)
      戸恒和人, 廣瀬卓男, 森信芳, 菊谷昌浩, 大久保孝義, 高橋和広, 今井潤
    • Organizer
      第84回日本内分泌学会学術総会
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report
  • [Presentation] ヒト血漿中(プロ)レニン受容体の検討2011

    • Author(s)
      戸恒和人, 廣瀬卓男, 森信芳, 浅山敬, 菊谷昌浩, 大久保孝義, 高橋和広, 今井潤
    • Organizer
      第54回日本腎臓学会総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] (Pro)renin receptor-like immunoreactivity in patients with chronic renal failure2011

    • Author(s)
      Kazuhito Totsune, Takuo Hirose, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Osamu Murakami, Yutaka Imai, Kazuhiro Takahashi
    • Organizer
      American Society of Nephrology Renal Week 2011
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Immunoreactive (pro)renin receptor in plasma and urine2011

    • Author(s)
      Kazuhito Totsune, Takuo Hirose, Nobuyoshi Mori, Kei Asayama, Masahiro Kikuya, Osamu Murakami, Yutaka Imai, Kazuhiro Takahashi
    • Organizer
      P2R symposium(招待講演)
    • Place of Presentation
      Paris, France
    • Related Report
      2011 Research-status Report
  • [Presentation] Dissecting the role of PRR in the cerebral cortex2011

    • Author(s)
      Alfredo Cabrera-Socorro, Takuo Hirose
    • Organizer
      P2R symposium(招待講演)
    • Place of Presentation
      Paris, France
    • Related Report
      2011 Research-status Report
  • [Presentation] ヒトリンパ球に存在する(プロ)レニン受容体の機能について

    • Author(s)
      鳴海かほり, 森建文, 石川繭子, 廣瀬卓男, 石井智徳, 伊藤貞嘉
    • Organizer
      第85回日本内分泌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒトリンパ球における(プロ)レニン受容体の検討

    • Author(s)
      鳴海かほり, 森建文, 佐藤恵美子, 石川繭子, 廣瀬卓男, 石井智徳, 伊藤貞嘉
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 副腎腫瘍における(プロ)レニン受容体mRNA発現の検討:アルドステロン産生副腎皮質腺腫における発現増加

    • Author(s)
      山本肇, 金子桐子, 大場浩史, 森本玲, 廣瀬卓男, 佐藤文俊, 戸恒和人, 高橋和広
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] Increased expression of (pro)renin receptor in remnant kidney of 5/6 nephrectomized rats

    • Author(s)
      Takuo Hirose, Genevieve Nguyen, Kazuhito Totsune
    • Organizer
      1st German French Symposium in Berlin
    • Place of Presentation
      Berlin, German
    • Related Report
      2012 Annual Research Report
  • [Presentation] Functional (pro)renin receptor in human lymphocytes and monocytes

    • Author(s)
      Kaori Narumi, Takuo Hirose, Emiko Sato, Mayuko Ishikawa, Kiyomi Kisu, Takefumi Mori, Sadayoshi Ito
    • Organizer
      German Society of Hypertension 2012
    • Place of Presentation
      Berlin, German
    • Related Report
      2012 Annual Research Report
  • [Presentation] (プロ)レニン受容体とWntシグナル

    • Author(s)
      廣瀬卓男, Genevieve Nguyen
    • Organizer
      第86回日本内分泌学会学術総会
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] 腎臓リハビリテーション腎内分泌とその機能-レニン・アンジオテンシン系、カリクレイン・キニン系、ナトリウム利尿ペプチド系、プロスタノイド、エンドセリン、一酸化窒素、アドレノメデュリン-2012

    • Author(s)
      廣瀬卓男,森建文,伊藤貞嘉
    • Publisher
      医歯薬出版
    • Related Report
      2012 Final Research Report
  • [Book] 腎臓リハビリテーション 腎内分泌とその機能 - レニン・アンジオテンシン系、カリクレイン・キニン系、ナトリウム利尿ペプチド系、プロスタノイド、エンドセリン、一酸化窒素、アドレノメデュリン2012

    • Author(s)
      廣瀬卓男、森建文、伊藤貞嘉
    • Publisher
      医歯薬出版
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.int2.med.tohoku.ac.jp/

    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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