Role of membrane-bound serine protease inhibitor in maintaining integrity of intestinal epithelium
| Project/Area Number |
23790250
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 腸上皮 / セリンプロテアーゼ / 細胞膜結合型セリンプロテアーゼインヒビター / 上皮機能 / プロテアーゼ / 病理学 |
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| Research Abstract |
To analyze the role of HAI-1 in intestine, we used intestinal tissue-specific HAI-1 conditional deficient mice. We found morphological abnormalities in the colonic epithelium with enhanced epithelial cell apoptosis and increased mucosal permeability. Moreover, mice lacking intestinal HAI-1 showed significantly enhanced susceptibility to colitis induced by dextran sodium sulfate (DSS) exposure. These results suggest that HAI-1/SPINT1 plays an important role in maintaining colonic epithelium integrity.
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Report
(3 results)
Research Products
(26 results)
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[Presentation] Ye JJ, Kawaguchi M, Haruyama Y, Kanemaru A, Fukushima T, Kataoka H2013
Author(s)
Ye JJ, Kawaguchi M, Haruyama Y, Kanemaru A, Fukushima T, Kataoka H
Organizer
An AACR Special Conference on Tumor Invasion and Metastasis.
Place of Presentation
San Diego, CA, USA
Year and Date
2013-01-21
Related Report
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