Molecular mechanism of negative regulation of human leukocytes byATP and STAT3

• Project/Area Number: 23790253
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General physiology
• Research Institution: Osaka City University
• Principal Investigator: KATO Takayuki 大阪市立大学, 大学院・医学研究科, 講師 (50343413)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 受容体 / 細胞内シグナル伝達 / 自然免疫 / 白血球 / 炎症性サイトカイン / Toll-like receptor / ATP / 好中球 / P2Y / STAT3 / MAPK / G-CSF / ヒト好中球

Research Abstract

Leukocytes (neutrophils and monocytes) express various TLR(s) andhave played the important role in the innate immune system that defense against invading bacteria, fungi. Although there are many insights about the cell activation mechanism thro

Research Products

• [Journal Article] S1-1/RBM10: Multiplicity and cooperativity of nuclear localization domains. (2013)
  • Author(s): Xiao S, Wang L, Kimura M, Kojima H, Kunimoto H, Nishiumi F, Yamamoto N, Nishio K, Fujimoto S, Kato T, Kitagawa S, Yamane H, Nakajima K, Inoue A.
  • Journal Title: Biol. Cell Volume: 105 Issue: 4 Pages: 162-174
  • DOI: 10.1111/boc.201200068
  • Peer Reviewed
• [Journal Article] Stimulation of human formyl peptide receptors by calpain inhibitors : Homology modeling of receptors and ligand docking simulation (2011)
  • Author(s): Fujita H, Kato T, Watanabe N, Takahashi T, Kitagawa S
  • Journal Title: Arch Biochem Biophys Volume: 516 Issue: 2 Pages: 121-127
  • DOI: 10.1016/j.abb.2011.09.017
  • Peer Reviewed
• [Journal Article] Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development (2011)
  • Author(s): Yamamoto M, et al
  • Journal Title: PLoS ONE Volume: 6 Issue: 10 Pages: e25812-e25812
  • DOI: 10.1371/journal.pone.0025812
  • Peer Reviewed
• [Journal Article] Calpain inhibitors stimulate phagocyte functions via activation of human formyl peptide receptors (2011)
  • Author(s): Fujita H, Kato T, Watanabe N, Takahashi T, Kitagawa S
  • Journal Title: Arch Biochem Biophys Volume: 513 Issue: 1 Pages: 51-60
  • DOI: 10.1016/j.abb.2011.06.007
  • Peer Reviewed
• [Presentation] カルパイン阻害剤はヒト・フォルミルペプチド受容体と直接相互作用して細胞機能を活性化する (2012)
  • Author(s): 藤田寿一、加藤隆幸、渡邊哲史、高橋達治、北川誠一
  • Organizer: 第105回近畿生理学談話会
  • Place of Presentation: 関西医科大学, 滝井学舎 1 号館, 大阪
  • Year and Date: 2012-09-29
• [Presentation] Roles of IRF4 and IRF8 in Myeloid Cell Development (2012)
  • Author(s): 加藤隆幸、他
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 長野県松本市
  • Year and Date: 2012-03-31
• [Presentation] カルパイン阻害剤はヒト・フォルミルペプチド受容体と直接相互作用して活性化する (2012)
  • Author(s): 藤田寿一、加藤隆幸、渡邊哲史、高橋達治、北川誠一
  • Organizer: 第33回日本炎症・再生医学会
  • Place of Presentation: ホテル日航福岡, 福岡
• [Presentation] Activation of human formyl peptide receptors by calpain inhibitors (2012)
  • Author(s): 藤田寿一、加藤隆幸、渡邊哲史、高橋達治、北川誠一
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 国立京都国際会館, 京都
• [Presentation] カルパイン阻害剤はヒト・フォルミルペプチド受容体と直接相互作用して活性化する (2012)
  • Author(s): 藤田寿一、加藤隆幸、渡邊哲史、高橋達治、北川誠一
  • Organizer: 第33回 日本炎症・再生医学会
  • Place of Presentation: ホテル日航福岡, 福岡
• [Presentation] Activation of human formyl peptide receptors by calpain inhibitors (2012)
  • Author(s): 藤田寿一、加藤隆幸、渡邊哲史、高橋達治、北川誠一
  • Organizer: 第74回 日本血液学会学術集会
  • Place of Presentation: 国立京都国際会館, 京都
• [Presentation] カルパイン阻害剤はヒトホルミルペプチド受容体を介して食細胞機能を活性化する (2011)
  • Author(s): 藤田寿一、加藤隆幸、渡邊哲史、高橋達治、北川誠一
  • Organizer: 第104回近畿生理学談話会
  • Place of Presentation: 大阪医科大学, 大阪
  • Year and Date: 2011-10-01
• [Presentation] Negative regulation of G-CSF on TLR agonist-induced TNF production in human monocytes and neutrophils (2011)
  • Author(s): Kato T, Fujita H, Watanabe N, KitagawaS
  • Organizer: 13th International TNF Conference (TNF2011)
  • Place of Presentation: Awaji Yumebutai International Conference Center, 兵庫県
  • Year and Date: 2011-05-16
• [Presentation] カルパイン阻害剤はヒト・フォルミルペプチド受容体と直接相互作用して細胞機能を活性化する
  • Author(s): 藤田寿一、加藤隆幸、渡邊哲史、高橋達治、北川誠一
  • Organizer: 第105回 近畿生理学談話会
  • Place of Presentation: 関西医科大学, 滝井学舎1号館, 大阪
• [Presentation] Roles of IRF4 and IRF8 in Myeloid Cell Development
  • Author(s): Kato T, 他13
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 長野県松本市
• [Book] Biological Effects of Calpain Inhibitors on Human Phagocyte Functions. In: Enzymes and Enzyme Activity. Chapter V. ed. E.M. Lashinski, (2013)
  • Author(s): Kitagawa S, Kato T, Kitagawa M, Aomatsu M, Fujita H
  • Publisher: Nova Science Publishers, Inc. NY
• [Book] Biological Effects of Calpain Inhibitors on Human Phagocyte Functions. In: Enzymes and Enzyme Activity.
  • Author(s): Kitagawa S, Kato T, 他、Chapter V. ed. E.M. Lashinski
  • Publisher: Nova Science Publishers, Inc. NY
• [Remarks]
  • URL: http://www.med.osaka-cu.ac.jp/physiology2/