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The involvement of astrocytes in the synaptic formation

Research Project

Project/Area Number 23790257
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionMeiji Pharmaceutical University

Principal Investigator

OGAWA YASUHIRO  明治薬科大学, 薬学部, 講師 (00531948)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords分子・細胞生理学 / ニューロン―グリア相互作用 / 神経科学 / 脳・神経 / シナプス / グリア細胞 / アストロサイト / イオンチャネル
Research Abstract

The purpose of this study was to analyze the involvement of astrocytes in the synaptic formation in brain. We established with success a visualization of synaptic formation and a mRNA collection from the target cells in vivo. Using analysis of microarray gene expression data, it was also found that Foxh1 gene, which interacts with SMAD signaling, and its target molecules were over-expressed in the astrocytes derived from the model mice.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (15 results)

All 2014 2013 2012 2011

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (8 results)

  • [Journal Article] Three mechanisms assemble central nervous system nodes of Ranvier2013

    • Author(s)
      Susuki K, Chang KJ, Zollinger DR, Liu Y, Ogawa Y, Eshed-Eisenbach Y, Dours-Zimmermann MT, Oses-Prieto JA, Burlingame AL, Seidenbecher CI, Zimmermann DR, Oohashi T, Peles E, Rasband MN
    • Journal Title

      Neuron

      Volume: 78 Pages: 469-482

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired neural differentiation of induced pluripotent stem cells generated from a mouse model of Sandhoff disease2013

    • Author(s)
      Ogawa Y, Tanaka M, Tanabe M, Suzuki T, Togawa T, Fukushige T, Kanekura T, Sakuraba H, Oishi K
    • Journal Title

      PLoS ONE

      Volume: 8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Three mechanisms assemble central nervous system nodes of Ranvier.2013

    • Author(s)
      Susuki K, Chang KJ, Zollinger DR, Liu Y, Ogawa Y, Eshed-Eisenbach Y, Dours-Zimmermann MT, Oses-Prieto JA, Burlingame AL, Seidenbecher CI, Zimmermann DR, Oohashi T, Peles E, Rasband MN.
    • Journal Title

      Neuron

      Volume: 78 Issue: 3 Pages: 469-482

    • DOI

      10.1016/j.neuron.2013.03.005

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired neural differentiation of induced pluripotent stem cells generated from a mouse model of Sandhoff disease.2013

    • Author(s)
      Ogawa Y, Tanaka M, Tanabe M, Suzuki T, Togawa T, Fukushige T, Kanekura T, Sakuraba H, Oishi K.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 1 Pages: e55856-e55856

    • DOI

      10.1371/journal.pone.0055856

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly2012

    • Author(s)
      Galiano MR, Jha S, Ho TS, Zhang C, Ogawa Y, Chang KJ, Stankewich MC, Mohler PJ, Rasband MN
    • Journal Title

      Cell

      Volume: 149 Pages: 1125-1139

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly.2012

    • Author(s)
      Galiano MR, Jha S, Ho TS, Zhang C, Ogawa Y, Chang KJ, Stankewich MC, Mohler PJ, Rasband MN.
    • Journal Title

      Cell

      Volume: 149 Issue: 5 Pages: 1125-1139

    • DOI

      10.1016/j.cell.2012.03.039

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Schwann cell spectrins modulate peripheral nerve myelination2011

    • Author(s)
      Susuki K, Raphael AR, Ogawa Y, Stankewich MC, Peles E, Talbot WS, Rasband MN
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 108 Pages: 8009-8014

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] ザンドホッフ病モデルマウス脳の早期異常を見つけました2014

    • Author(s)
      小川泰弘、大石一彦
    • Organizer
      臨床遺伝学公開シンポジウム
    • Place of Presentation
      明治薬科大学総合教育研究棟フロネシス
    • Year and Date
      2014-03-14
    • Related Report
      2013 Final Research Report
  • [Presentation] P0-Cre x Z/EGトランスジェニックマウスから作製したiPS細胞2014

    • Author(s)
      江東洗、小川泰弘、大石一彦
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2013 Final Research Report
  • [Presentation] ザンドホッフ病モデルマウスにおいてグリオーシスが発症前に起きている2014

    • Author(s)
      佐野貴文、小川泰弘、棲庭均、大石一彦
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2013 Final Research Report
  • [Presentation] ザンドホッフ病モデルマウスから作製したiPS細胞2014

    • Author(s)
      田中真、小川泰弘、鈴木俊宏、兎川忠靖、棲庭均、大石一彦
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Final Research Report
  • [Presentation] Induced pluripotent stem cells generated from P0-Cre x Z/EG transgenic mice2014

    • Author(s)
      Eto A, Ogawa Y, Oishi K.
    • Organizer
      薬理学会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2013 Annual Research Report
  • [Presentation] Astrogliosis begins at presymptomatic stages in a mouse model of Sandhoff di sease2014

    • Author(s)
      Sano T, Ogawa Y, Sakuraba H, Oishi K.
    • Organizer
      薬理学会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2013 Annual Research Report
  • [Presentation] ザンドホッフ病モデルマウス由来iPS細胞はニューロンに分化しにくいことを見つけました2013

    • Author(s)
      高田昂、小川泰弘、大石一彦
    • Organizer
      臨床遺伝学公開シンポジウム
    • Place of Presentation
      明治薬科大学総合教育研究棟フロネシス
    • Year and Date
      2013-03-05
    • Related Report
      2013 Final Research Report
  • [Presentation] ザンドホッフ病モデルマウス由来iPS細胞から神経系細胞を作りました2012

    • Author(s)
      小川泰弘、大石一彦
    • Place of Presentation
      明治薬科大学総合教育研究棟フロネシス
    • Year and Date
      2012-03-10
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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