The analysis for sex difference of somatic cells via DM-domain related transcription factors

• Project/Area Number: 23790258
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General physiology
• Research Institution: Ritsumeikan University
• Principal Investigator: INOUE Hideki 立命館大学, 生命科学部, 助教 (20550156)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 性差 / DM ドメイン型転写因子 / DMドメイン / 乳癌 / DMドメイン型転写因子 / 線虫

Research Abstract

It has been reported that DM-domain transcription factor, DMRT, gives sex difference through regulating the development of male sex organ. We studied whether the DMRT express in other somatic cells and give sex difference. Expression of DMRT genes was observed several organs in mice, moreover, sex-specific expression of DMRT genes were observed in heart. In addition, we observed that DMRT2 suppresses cell proliferation of MCF-7, breast cancer cell line. These results suggest that DMRT genes have physiological functionin somatic tissues except for sex organs.