The investigation and identification of key molecules in the calciumoscillation-independent osteoclastogenesis

• Project/Area Number: 23790265
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General physiology
• Research Institution: Keio University
• Principal Investigator: KURODA Yukiko 慶應義塾大学, 医学部, 特任助教 (70455343)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: シグナル伝達・分化 / 破骨細胞 / リン酸化 / イノシトール三リン酸受容体 / NFATc1 / Cot kinase / シグナル伝達 / 分化 / イノシトール３リン酸受容体

Research Abstract

In this study, I found that direct contact between osteoclasts and osteoblasts,especially membrane fraction molecule(s) of osteoblasts, is required for the inductionof Ca^<2+>oscillation-independent osteoclastogenesis. Moreover, I revealed that Cot, aseri

Research Products

• [Journal Article] Regulation of osteoclasts by membrane-derived lipid mediators (2013)
  • Author(s): Oikawa T, Kuroda Y, Matsuo K
  • Journal Title: Cell Mol Life Sci Volume: 70(18) Issue: 18 Pages: 3341-3353
  • DOI: 10.1007/s00018-012-1238-4
  • Peer Reviewed
• [Journal Article] Molecular mechanisms of triggering, amplifying and targeting RANK signaling in osteoclasts. (2012)
  • Author(s): Yukiko Kuroda
  • Journal Title: World J Orthop. Volume: 3 Issue: 11 Pages: 167-174
  • DOI: 10.5312/wjo.v3.i11.167
  • Peer Reviewed
• [Journal Article] Cot Kinase Promotes Ca2+ Oscillation/Calcineurin-independent Osteoclastogenesis by Stabilizing NFATc1 Protein (2012)
  • Author(s): Kuroda Y
  • Journal Title: Mol Cell Biology Volume: 32(14) Issue: 14 Pages: 2954-63
  • DOI: 10.1128/mcb.05611-11
  • Peer Reviewed
• [Presentation] Cot kinase promotes Ca^<2+>oscillation/calcineurin-independent osteoclastogenesis by stabilizingNFATc1 protein (2012)
  • Author(s): Yukiko Kuroda, Chihiro Hisatsune,Akihiro Mizutani, Naoko Ogawa, KoichiMatsuo, Katsuhiko Mikoshiba
  • Organizer: The American Society for Bone andMineral Research
  • Place of Presentation: Minneapolis, Minnesota USA
• [Presentation] Ca^<2+> oscillation/Calcineurin 非依存的破骨細胞分化メカニズム ～Cotkinase によるリン酸化がNFATc1 のタンパク質安定化、発現量増加を誘導する (2012)
  • Author(s): 黒田 有希子、久恒 智博、水谷顕洋、小川 直子、松尾 光一、御子柴克彦
  • Organizer: 日本骨代謝学会学術集
  • Place of Presentation: 東京、日本
• [Presentation] Cot kinase promotes Ca2+ oscillation/calcineurin-independent osteoclastogenesis by stabilizing NFATc1 protein (2012)
  • Author(s): Yukiko Kuroda
  • Organizer: The American Society for Bone and Mineral Research
  • Place of Presentation: Minneapolis, Minnesota USA
• [Presentation] Ca2+ oscillation/Calcineurin 非依存的破骨細胞分化メカニズム ～Cot kinase によるリン酸化がNFATc1 のタンパク質安定化、発現量増加を誘導する (2012)
  • Author(s): 黒田 有希子
  • Organizer: 日本骨代謝学会学術集会
  • Place of Presentation: 東京