Molecular Mechanism of the maternal-fetal mineral transport for fetal bone mineralization
| Project/Area Number |
23790266
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設) (2012)
National Institutes of Natural Sciences Okazaki Research Facilities (2011) |
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Principal Investigator |
SUZUKI Yoshiro 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 助教 (40348503)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | カルシウム / マグネシウム / 胎盤 / 母子間輸送 / TRP チャネル / TRPチャネル |
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| Research Abstract |
Fetus develops mineralized bones during very last days of pregnancy. However, the molecular mechanism of the mineral transport has still been unclear. In an attempt to the molecular identification of the maternal-fetal mineral transport during fetal bone formation, I found TRPM6 as a candidate mineral entry pathway. TRPM6 was mainly localized in the intraplacental yolk sac, which is thought to be the place for the maternal-fetal mineral transport, and its expression was significantly increased during the last 4 days of pregnancy, which coincides with the fetal bone formation in mice. Moreover, TRPM6-like activity was observed in a cell line derived from human placental trophoblasts. These results suggest that TRPM6 plays an important role in the maternal-fetal mineral transport in order to sustain fetal bone formation.
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Report
(3 results)
Research Products
(20 results)
