• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular Mechanism of the maternal-fetal mineral transport for fetal bone mineralization

Research Project

Project/Area Number 23790266
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General physiology
Research Institution大学共同利用機関法人自然科学研究機構(岡崎共通研究施設) (2012)
National Institutes of Natural Sciences Okazaki Research Facilities (2011)

Principal Investigator

SUZUKI Yoshiro  大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 助教 (40348503)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsカルシウム / マグネシウム / 胎盤 / 母子間輸送 / TRP チャネル / TRPチャネル
Research Abstract

Fetus develops mineralized bones during very last days of pregnancy. However, the molecular mechanism of the mineral transport has still been unclear. In an attempt to the molecular identification of the maternal-fetal mineral transport during fetal bone formation, I found TRPM6 as a candidate mineral entry pathway. TRPM6 was mainly localized in the intraplacental yolk sac, which is thought to be the place for the maternal-fetal mineral transport, and its expression was significantly increased during the last 4 days of pregnancy, which coincides with the fetal bone formation in mice. Moreover, TRPM6-like activity was observed in a cell line derived from human placental trophoblasts. These results suggest that TRPM6 plays an important role in the maternal-fetal mineral transport in order to sustain fetal bone formation.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (20 results)

All 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (12 results) Remarks (3 results)

  • [Journal Article] カルシウム輸送体TRPV5/6の機能と異常2013

    • Author(s)
      鈴木喜郎
    • Journal Title

      腎と骨代謝

      Volume: 26

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] TRPV6 permeates several heavy metals.2011

    • Author(s)
      Kovacs G et al
    • Journal Title

      Cell Calcium

      Volume: 49 Pages: 43-55

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemical inhibitors of the calcium entry channel TRPV6.2011

    • Author(s)
      Landowski CP, et al
    • Journal Title

      Pharm Res

      Volume: 28 Pages: 322-330

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] TRPV6 permeates several heavy metals.2011

    • Author(s)
      Kovacs G, et al.
    • Journal Title

      Cell Calcium

      Volume: 49 (1) Issue: 1 Pages: 43-55

    • DOI

      10.1016/j.ceca.2010.11.007

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chemical inhibitors of the calcium entry channel2011

    • Author(s)
      Landowski CP, et al.
    • Journal Title

      Pharmaceutical Research

      Volume: 28 (2) Issue: 2 Pages: 322-330

    • DOI

      10.1007/s11095-010-0249-9

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Roles of TRPV6 and TRPM6 channels in maternal-fetal calcium transpor2012

    • Author(s)
      Yoshiro Suzuki
    • Organizer
      International Symposium on Epithelial Barrier and Transport
    • Place of Presentation
      滋賀県(口演)
    • Year and Date
      2012-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Epithelial TRP channels for maternal-fetal calcium transport2012

    • Author(s)
      Yoshiro Suzuki
    • Organizer
      2012 International Ion Channel Conference
    • Place of Presentation
      韓国・済州島(ポスター)
    • Year and Date
      2012-08-25
    • Related Report
      2012 Final Research Report
  • [Presentation] TRPM6 の母子間カルシウムおよびマグネシウム輸送における役割2012

    • Author(s)
      鈴木喜郎
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県(ポスター)
    • Year and Date
      2012-03-30
    • Related Report
      2012 Final Research Report
  • [Presentation] TRPM6の母子間カルシウムおよびマグネシウム輸送における役割2012

    • Author(s)
      鈴木喜郎
    • Organizer
      第89回日本生理学会大会(一般演題・ポスター)
    • Place of Presentation
      松本市総合体育館(長野県)
    • Related Report
      2011 Research-status Report
  • [Presentation] TRP チャネルの母子間ミネラル輸送における役割2011

    • Author(s)
      鈴木喜郎
    • Organizer
      第58回中部日本生理学会大会
    • Place of Presentation
      福井県(一般口演)
    • Year and Date
      2011-11-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Roles of TRP channels for maternal-fetal mineral transport2011

    • Author(s)
      Yoshiro Suzuki
    • Organizer
      International Joint Meeting of Cellular and Molecular Physiology
    • Place of Presentation
      東京都(口演)
    • Year and Date
      2011-07-31
    • Related Report
      2012 Final Research Report
  • [Presentation] 胎仔骨石灰化のための母子間マグネシウム輸送に関与する分子の探索2011

    • Author(s)
      鈴木喜郎
    • Organizer
      第22回日本微量元素学会学術総会
    • Place of Presentation
      京都府(一般口演)
    • Year and Date
      2011-07-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 胎仔骨石灰化のための母子間マグネシウム輸送に関与する分子の探索2011

    • Author(s)
      鈴木喜郎
    • Organizer
      第22回日本微量元素学会学術集会(一般口演)
    • Place of Presentation
      京都テルサ(京都府)
    • Related Report
      2011 Research-status Report
  • [Presentation] Roles of TRP channels for maternal-fetal mineral2011

    • Author(s)
      Yoshiro Suzuki
    • Organizer
      International Joint Meeting of Cellular and
    • Place of Presentation
      北里大学薬学部(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] TRPチャネルの母子間ミネラル輸送における役割2011

    • Author(s)
      鈴木喜郎
    • Organizer
      第58回中部日本生理学会大会(一般口演)
    • Place of Presentation
      福井県県民ホール(福井県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Epithelial TRP channels for maternal-fetal calcium transport

    • Author(s)
      Yoshiro Suzuki
    • Organizer
      2012 International Ion Channel Conference
    • Place of Presentation
      The Shilla Hotel Jeju (Korea)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Roles of TRPV6 and TRPM6 channels in maternal-fetal calcium transport

    • Author(s)
      Yoshiro Suzuki
    • Organizer
      International Symposium on Epithelial Barrier and Transport
    • Place of Presentation
      エポック立命(滋賀県)
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://researchmap.jp/yoshiro/

    • Related Report
      2012 Final Research Report
  • [Remarks] 鈴木喜郎

    • URL

      http://researchmap.jp/yoshiro/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://researchmap.jp/yoshiro/

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi