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Molecular analysis of immune regulation by estrogen signaling through the G-coupled receptor

Research Project

Project/Area Number 23790273
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionAzabu University

Principal Investigator

OKAMOTO Mariko  麻布大学, 獣医学部, 講師 (30415111)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsGPR30 / 自然免疫 / IL-6 / シグナル伝達 / NFkB / GPER / 炎症性サイトカイン
Research Abstract

Estrogen effects the immune response through ERalpha or ERbeta, but recently the involvement of GPR30 (G protein Coupled Receptor 30), a membrane-type estrogen receptor, in anti inflammatory response is reported. This study investigated the molecular mechanism about the regulation of inflammatory cytokines by GPR30. We found that the treatment of GPR30 by G-1, GPR30 specific agonist, suppressed the expression of inflammatory cytokine IL-6 in macrophage cell line stimulated with LPS. G-1 also decreased NFkB promoter activation by LPS, and phosphorylation of kinases which involved in the translocation of transcription factor NFkB from cytosol to nucleus.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2013 Other

All Presentation (6 results) (of which Invited: 2 results) Remarks (2 results)

  • [Presentation] マクロファージにおけるGPR30による炎症性サイトカインの制御2013

    • Author(s)
      鈴木拓人、潮崎日名子、水上洋一、池田輝雄、岡本まり子
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸市(兵庫県)
    • Year and Date
      2013-12-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Helicobacter pylori CagAによる胃細胞でのNF-kB経路活性化におけるGPR30の関与について2013

    • Author(s)
      三浦篤史、伊東諒太、鎌田駿季、池田輝雄、岡本まり子
    • Organizer
      第88回麻布獣医学会
    • Place of Presentation
      山口市(山口県)
    • Year and Date
      2013-11-03
    • Related Report
      2013 Final Research Report
  • [Presentation] 獣医師のための免疫の基礎について2013

    • Author(s)
      岡本まり子
    • Organizer
      平成25年度公益法人徳島県獣医師会小動物講習会
    • Place of Presentation
      徳島市(徳島県)
    • Year and Date
      2013-08-11
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] マクロファージにおけるGPR30による炎症性サイトカインの制御

    • Author(s)
      鈴木拓人、潮崎日名子、水上洋一、池田輝雄、岡本まり子
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸(兵庫、日本)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Helicobactor pylori CagA による胃細胞での NF-kB 経路活性化における GPR30 の関与について

    • Author(s)
      三浦篤史、伊東諒太、鎌田駿季、池田輝雄、岡本まり子
    • Organizer
      第88回麻布獣医学会
    • Place of Presentation
      山口(山口、日本)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 獣医師のための免疫の基礎について

    • Author(s)
      岡本まり子
    • Organizer
      平成25年度公益社団法人徳島県獣医師会小動物講習会
    • Place of Presentation
      徳島(徳島、日本)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Remarks]

    • URL

      http://www.azabu-u.ac.jp/

    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.azabu-u.ac.jp/lab/vv/vv_009.html

    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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