| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Estrogen effects the immune response through ERalpha or ERbeta, but recently the involvement of GPR30 (G protein Coupled Receptor 30), a membrane-type estrogen receptor, in anti inflammatory response is reported. This study investigated the molecular mechanism about the regulation of inflammatory cytokines by GPR30. We found that the treatment of GPR30 by G-1, GPR30 specific agonist, suppressed the expression of inflammatory cytokine IL-6 in macrophage cell line stimulated with LPS. G-1 also decreased NFkB promoter activation by LPS, and phosphorylation of kinases which involved in the translocation of transcription factor NFkB from cytosol to nucleus.
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